 Leukemia, Megakaryoblastic, Acute
"Leukemia, Megakaryoblastic, Acute" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An acute myeloid leukemia in which 20-30% of the bone marrow or peripheral blood cells are of megakaryocyte lineage. MYELOFIBROSIS or increased bone marrow RETICULIN is common.
| Descriptor ID |
D007947
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| MeSH Number(s) |
C04.557.337.539.550.450
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| Concept/Terms |
Leukemia, Megakaryoblastic, Acute- Leukemia, Megakaryoblastic, Acute
- Myeloid Leukemia, Acute, M7
- Megakaryocytic Leukemia, Acute
- Acute Megakaryocytic Leukemia
- Acute Megakaryocytic Leukemias
- Leukemia, Acute Megakaryocytic
- Leukemias, Acute Megakaryocytic
- Megakaryocytic Leukemias, Acute
- Megakaryocytic Leukemia
- Megakaryoblastic Leukemia, Acute
- Acute Megakaryoblastic Leukemia
- Acute Megakaryoblastic Leukemias
- Leukemia, Acute Megakaryoblastic
- Leukemias, Acute Megakaryoblastic
- Megakaryoblastic Leukemias, Acute
- Leukemia, Megakaryocytic
- Leukemias, Megakaryocytic
- Megakaryocytic Leukemias
- Leukemia, Myeloid, Acute, M7
- Leukemia, Megakaryocytic, Acute
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Below are MeSH descriptors whose meaning is more general than "Leukemia, Megakaryoblastic, Acute".
Below are MeSH descriptors whose meaning is more specific than "Leukemia, Megakaryoblastic, Acute".
This graph shows the total number of publications written about "Leukemia, Megakaryoblastic, Acute" by people in this website by year, and whether "Leukemia, Megakaryoblastic, Acute" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 2000 | 2 | 0 | 2 | | 2001 | 0 | 1 | 1 | | 2003 | 2 | 0 | 2 | | 2006 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Leukemia, Megakaryoblastic, Acute" by people in Profiles.
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Malinge S, Bliss-Moreau M, Kirsammer G, Diebold L, Chlon T, Gurbuxani S, Crispino JD. Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome. J Clin Invest. 2012 Mar; 122(3):948-62.
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Pullarkat ST, Vardiman JW, Slovak ML, Rao DS, Rao NP, Bedell V, Said JW. Megakaryocytic blast crisis as a presenting manifestation of chronic myeloid leukemia. Leuk Res. 2008 Nov; 32(11):1770-5.
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Gurbuxani S. CD36 - a marker for drug sensitive acute megakaryoblastic leukemia. Leuk Lymphoma. 2006 Oct; 47(10):2004-5.
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Greene ME, Mundschau G, Wechsler J, McDevitt M, Gamis A, Karp J, Gurbuxani S, Arceci R, Crispino JD. Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome. Blood Cells Mol Dis. 2003 Nov-Dec; 31(3):351-6.
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Mundschau G, Gurbuxani S, Gamis AS, Greene ME, Arceci RJ, Crispino JD. Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis. Blood. 2003 Jun 01; 101(11):4298-300.
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Wechsler J, Greene M, McDevitt MA, Anastasi J, Karp JE, Le Beau MM, Crispino JD. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nat Genet. 2002 Sep; 32(1):148-52.
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Arber DA. Realistic pathologic classification of acute myeloid leukemias. Am J Clin Pathol. 2001 Apr; 115(4):552-60.
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de Luna R, Eldibany MM, Weisenberg E, Rhone DP. Pathologic quiz case: male with nonproductive cough. Arch Pathol Lab Med. 2000 Sep; 124(9):1389-91.
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Bernstein J, Dastugue N, Haas OA, Harbott J, Heerema NA, Huret JL, Landman-Parker J, LeBeau MM, Leonard C, Mann G, Pages MP, Perot C, Pirc-Danoewinata H, Roitzheim B, Rubin CM, Slociak M, Viguie F. Nineteen cases of the t(1;22)(p13;q13) acute megakaryblastic leukaemia of infants/children and a review of 39 cases: report from a t(1;22) study group. Leukemia. 2000 Jan; 14(1):216-8.
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Matsuguchi T, Salgia R, Hallek M, Eder M, Druker B, Ernst TJ, Griffin JD. Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL. J Biol Chem. 1994 Feb 18; 269(7):5016-21.
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