 Disulfiram
"Disulfiram" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
| Descriptor ID |
D004221
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| MeSH Number(s) |
D02.241.081.251.869.220.250 D02.886.520.150.175 D02.886.706.200.200
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| Concept/Terms |
Disulfiram- Disulfiram
- Tetraethylthiuram Disulfide
- Disulfide, Tetraethylthiuram
- Bis(diethylthiocarbamoyl) Disulfide
- Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2
Antabuse- Antabuse
- Odyssey Brand of Disulfiram
- Orphan Brand of Disulfiram
- Allphar Brand of Disulfiram
Esperal- Esperal
- Sanofi Synthelabo Brand of Disulfiram
Refusal- Refusal
- Artu Brand of Disulfiram
Antabus- Antabus
- Bohm Brand of Disulfiram
- Dumex Brand of Disulfiram
- Altana Pharma Brand of Disulfiram
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Below are MeSH descriptors whose meaning is more general than "Disulfiram".
Below are MeSH descriptors whose meaning is more specific than "Disulfiram".
This graph shows the total number of publications written about "Disulfiram" by people in this website by year, and whether "Disulfiram" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1987 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Disulfiram" by people in Profiles.
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Pan M, Zheng Q, Yu Y, Ai H, Xie Y, Zeng X, Wang C, Liu L, Zhao M. Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative. Nat Commun. 2021 01 05; 12(1):121.
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Zhong Y, Sun R, Geng Y, Zhou Q, Piao Y, Xie T, Zhou R, Shen Y. N-Oxide polymer-cupric ion nanogels potentiate disulfiram for cancer therapy. Biomater Sci. 2020 Mar 17; 8(6):1726-1733.
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Grant JE, Potenza MN, Kraus SW, Petrakis IL. Naltrexone and Disulfiram Treatment Response in Veterans With Alcohol Dependence and Co-Occurring Problem-Gambling Features. J Clin Psychiatry. 2017 Nov/Dec; 78(9):e1299-e1306.
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Brar SS, Grigg C, Wilson KS, Holder WD, Dreau D, Austin C, Foster M, Ghio AJ, Whorton AR, Stowell GW, Whittall LB, Whittle RR, White DP, Kennedy TP. Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease. Mol Cancer Ther. 2004 Sep; 3(9):1049-60.
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Barth R, Resnick RH, Smoller B. Disulfiram and fulminant hepatitis. Dig Dis Sci. 1987 Sep; 32(9):1059.
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Major LF, Murphy DL, Gershon ES, Brown GL. The role of plasma amine oxidase, platelet monoamine oxidase, and red cell catechol-O-methyl transferase in severe behavioral reactions to disulfiram. Am J Psychiatry. 1979 May; 136(5):679-84.
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