"Disulfiram" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
| Descriptor ID |
D004221
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| MeSH Number(s) |
D02.241.081.251.869.220.250 D02.886.520.150.175 D02.886.706.200.200
|
| Concept/Terms |
Disulfiram- Disulfiram
- Bis(diethylthiocarbamoyl) Disulfide
- Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2
- Tetraethylthiuram Disulfide
- Disulfide, Tetraethylthiuram
|
Below are MeSH descriptors whose meaning is more general than "Disulfiram".
Below are MeSH descriptors whose meaning is more specific than "Disulfiram".
This graph shows the total number of publications written about "Disulfiram" by people in this website by year, and whether "Disulfiram" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Disulfiram" by people in Profiles.
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Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative. Nat Commun. 2021 01 05; 12(1):121.
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N-Oxide polymer-cupric ion nanogels potentiate disulfiram for cancer therapy. Biomater Sci. 2020 Mar 17; 8(6):1726-1733.
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Posterior Reversible Encephalopathy Syndrome Instigated by Off-Label Disulfiram Use for Metastatic Melanoma. Psychosomatics. 2020 May - Jun; 61(3):302-306.
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Naltrexone and Disulfiram Treatment Response in Veterans With Alcohol Dependence and Co-Occurring Problem-Gambling Features. J Clin Psychiatry. 2017 Nov/Dec; 78(9):e1299-e1306.
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Copper signaling axis as a target for prostate cancer therapeutics. Cancer Res. 2014 Oct 15; 74(20):5819-31.
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Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease. Mol Cancer Ther. 2004 Sep; 3(9):1049-60.
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Disulfiram and fulminant hepatitis. Dig Dis Sci. 1987 Sep; 32(9):1059.
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The role of plasma amine oxidase, platelet monoamine oxidase, and red cell catechol-O-methyl transferase in severe behavioral reactions to disulfiram. Am J Psychiatry. 1979 May; 136(5):679-84.