 Indomethacin
"Indomethacin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
| Descriptor ID |
D007213
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| MeSH Number(s) |
D03.438.473.420
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Indomethacin".
Below are MeSH descriptors whose meaning is more specific than "Indomethacin".
This graph shows the total number of publications written about "Indomethacin" by people in this website by year, and whether "Indomethacin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1982 | 1 | 0 | 1 | | 1983 | 3 | 0 | 3 | | 1984 | 1 | 0 | 1 | | 1985 | 0 | 1 | 1 | | 1986 | 1 | 1 | 2 | | 1987 | 0 | 1 | 1 | | 1988 | 0 | 1 | 1 | | 1989 | 0 | 2 | 2 | | 1990 | 1 | 0 | 1 | | 1991 | 1 | 2 | 3 | | 1993 | 0 | 3 | 3 | | 1994 | 0 | 4 | 4 | | 1995 | 1 | 7 | 8 | | 1996 | 0 | 3 | 3 | | 1997 | 0 | 1 | 1 | | 1998 | 1 | 0 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2008 | 2 | 1 | 3 | | 2012 | 2 | 0 | 2 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Indomethacin" by people in Profiles.
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Clyman RI, Liebowitz M, Kaempf J, Erdeve O, Bulbul A, Håkansson S, Lindqvist J, Farooqi A, Katheria A, Sauberan J, Singh J, Nelson K, Wickremasinghe A, Dong L, Hassinger DC, Aucott SW, Hayashi M, Heuchan AM, Carey WA, Derrick M, Fernandez E, Sankar M, Leone T, Perez J, Serize A. PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-to-Large Patent Ductus Arteriosus at 1 Week of Age. J Pediatr. 2019 02; 205:41-48.e6.
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Sharma P, Ryu MH, Basu S, Maltby SA, Yeganeh B, Mutawe MM, Mitchell RW, Halayko AJ. Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase. Br J Pharmacol. 2012 Oct; 167(3):548-60.
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Elmunzer BJ, Scheiman JM, Lehman GA, Chak A, Mosler P, Higgins PD, Hayward RA, Romagnuolo J, Elta GH, Sherman S, Waljee AK, Repaka A, Atkinson MR, Cote GA, Kwon RS, McHenry L, Piraka CR, Wamsteker EJ, Watkins JL, Korsnes SJ, Schmidt SE, Turner SM, Nicholson S, Fogel EL. A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis. N Engl J Med. 2012 Apr 12; 366(15):1414-22.
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Lu J, Caplan MS, Li D, Jilling T. Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2008 May; 294(5):G1181-90.
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Jegatheesan P, Ianus V, Buchh B, Yoon G, Chorne N, Ewig A, Lin E, Fields S, Moon-Grady A, Tacy T, Milstein J, Schreiber M, Padbury J, Clyman R. Increased indomethacin dosing for persistent patent ductus arteriosus in preterm infants: a multicenter, randomized, controlled trial. J Pediatr. 2008 Aug; 153(2):183-9.
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Abraham C, Hart J, Locke SM, Baker AL. A case of indometacin-induced acute hepatitis developing into chronic autoimmune hepatitis. Nat Clin Pract Gastroenterol Hepatol. 2008 Mar; 5(3):172-6.
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Hourvitz A, Gershon E, Hennebold JD, Elizur S, Maman E, Brendle C, Adashi EY, Dekel N. Ovulation-selective genes: the generation and characterization of an ovulatory-selective cDNA library. J Endocrinol. 2006 Mar; 188(3):531-48.
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Toback FG, Walsh-Reitz MM, Musch MW, Chang EB, Del Valle J, Ren H, Huang E, Martin TE. Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic. Am J Physiol Gastrointest Liver Physiol. 2003 Aug; 285(2):G344-53.
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Myou S, Sano H, Fujimura M, Zhu X, Kurashima K, Kita T, Nakao S, Nonomura A, Shioya T, Kim KP, Munoz NM, Cho W, Leff AR. Blockade of eosinophil migration and airway hyperresponsiveness by cPLA2-inhibition. Nat Immunol. 2001 Feb; 2(2):145-9.
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Marra DE, Simoncini T, Liao JK. Inhibition of vascular smooth muscle cell proliferation by sodium salicylate mediated by upregulation of p21(Waf1) and p27(Kip1). Circulation. 2000 Oct 24; 102(17):2124-30.
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