 Myosin-Light-Chain Kinase
"Myosin-Light-Chain Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that phosphorylates myosin light chains in the presence of ATP to yield myosin-light chain phosphate and ADP, and requires calcium and CALMODULIN. The 20-kDa light chain is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors. The enzyme plays a central role in the regulation of smooth muscle contraction.
| Descriptor ID |
D009219
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| MeSH Number(s) |
D08.811.913.696.620.682.700.125.500 D12.644.360.100.500 D12.776.476.100.500
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| Concept/Terms |
Myosin-Light-Chain Kinase- Myosin-Light-Chain Kinase
- Kinase, Myosin-Light-Chain
- Myosin Light Chain Kinase
- Myosin LCK
- LCK, Myosin
- Myosin Regulatory Light-Chain Kinase
- Myosin Regulatory Light Chain Kinase
- Myosin Kinase
- Kinase, Myosin
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Below are MeSH descriptors whose meaning is more general than "Myosin-Light-Chain Kinase".
Below are MeSH descriptors whose meaning is more specific than "Myosin-Light-Chain Kinase".
This graph shows the total number of publications written about "Myosin-Light-Chain Kinase" by people in this website by year, and whether "Myosin-Light-Chain Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1989 | 1 | 0 | 1 | | 1999 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 1 | 1 | 2 | | 2006 | 4 | 0 | 4 | | 2007 | 0 | 2 | 2 | | 2008 | 1 | 2 | 3 | | 2009 | 1 | 3 | 4 | | 2010 | 3 | 0 | 3 | | 2011 | 1 | 3 | 4 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 1 | 2 | | 2015 | 2 | 0 | 2 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 2 | 0 | 2 | | 2019 | 2 | 0 | 2 |
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Below are the most recent publications written about "Myosin-Light-Chain Kinase" by people in Profiles.
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Graham WV, He W, Marchiando AM, Zha J, Singh G, Li HS, Biswas A, Ong MLDM, Jiang ZH, Choi W, Zuccola H, Wang Y, Griffith J, Wu J, Rosenberg HJ, Wang Y, Snapper SB, Ostrov D, Meredith SC, Miller LW, Turner JR. Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis. Nat Med. 2019 04; 25(4):690-700.
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Nalle SC, Zuo L, Ong MLDM, Singh G, Worthylake AM, Choi W, Manresa MC, Southworth AP, Edelblum KL, Baker GJ, Joseph NE, Savage PA, Turner JR. Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability. J Clin Invest. 2019 02 01; 129(2):902-914.
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Xu J, Vanderzalm PJ, Ludwig M, Su T, Tokamov SA, Fehon RG. Yorkie Functions at the Cell Cortex to Promote Myosin Activation in a Non-transcriptional Manner. Dev Cell. 2018 08 06; 46(3):271-284.e5.
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Mascarenhas JB, Tchourbanov AY, Danilov SM, Zhou T, Wang T, Garcia JGN. The Splicing Factor hnRNPA1 Regulates Alternate Splicing of the MYLK Gene. Am J Respir Cell Mol Biol. 2018 05; 58(5):604-613.
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Mascarenhas JB, Tchourbanov AY, Fan H, Danilov SM, Wang T, Garcia JG. Mechanical Stress and Single Nucleotide Variants Regulate Alternative Splicing of the MYLK Gene. Am J Respir Cell Mol Biol. 2017 01; 56(1):29-37.
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Alcala DB, Haldeman BD, Brizendine RK, Krenc AK, Baker JE, Rock RS, Cremo CR. Myosin light chain kinase steady-state kinetics: comparison of smooth muscle myosin II and nonmuscle myosin IIB as substrates. Cell Biochem Funct. 2016 Oct; 34(7):469-474.
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Du J, Chen Y, Shi Y, Liu T, Cao Y, Tang Y, Ge X, Nie H, Zheng C, Li YC. 1,25-Dihydroxyvitamin D Protects Intestinal Epithelial Barrier by Regulating the Myosin Light Chain Kinase Signaling Pathway. Inflamm Bowel Dis. 2015 Nov; 21(11):2495-506.
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Acosta-Herrera M, Pino-Yanes M, Ma SF, Barreto-Luis A, Corrales A, Cumplido J, Pérez-Rodríguez E, Campo P, Eng C, García-Robaina JC, Quintela I, Villar J, Blanca M, Carracedo Á, Carrillo T, Garcia JG, Torgerson DG, Burchard EG, Flores C. Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent. J Allergy Clin Immunol. 2015 Oct; 136(4):1116-8.e9.
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Chen P, Stärkel P, Turner JR, Ho SB, Schnabl B. Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice. Hepatology. 2015 Mar; 61(3):883-94.
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Chen MM, Zahs A, Brown MM, Ramirez L, Turner JR, Choudhry MA, Kovacs EJ. An alteration of the gut-liver axis drives pulmonary inflammation after intoxication and burn injury in mice. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 01; 307(7):G711-8.
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