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Aaron Esser-Kahn

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentPritzker Institute for Molecular Engineering
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kim SM, Studnitzer B, Esser-Kahn A. Heat Shock Protein 90's Mechanistic Role in Contact Hypersensitivity. J Immunol. 2022 Jun 08. PMID: 35675957.
      View in: PubMed
    2. Hernandez-Davies JE, Dollinger EP, Pone EJ, Felgner J, Liang L, Strohmeier S, Jan S, Albin TJ, Jain A, Nakajima R, Jasinskas A, Krammer F, Esser-Kahn A, Felgner PL, Nie Q, Davies DH. Magnitude and breadth of antibody cross-reactivity induced by recombinant influenza hemagglutinin trimer vaccine is enhanced by combination adjuvants. Sci Rep. 2022 Jun 02; 12(1):9198. PMID: 35654904.
      View in: PubMed
    3. Deak P, Knight HR, Esser-Kahn A. Robust tolerogenic dendritic cells via push/pull pairing of toll-like-receptor agonists and immunomodulators reduces EAE. Biomaterials. 2022 Jul; 286:121571. PMID: 35597168.
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    4. Gao Y, Dearborn MA, Hemmer J, Wang Z, Esser-Kahn AP, Geubelle PH. Controllable Frontal Polymerization and Spontaneous Patterning Enabled by Phase-Changing Particles. Small. 2021 10; 17(42):e2102217. PMID: 34528371.
      View in: PubMed
    5. Kimani FW, Manna S, Moser B, Shen J, Nihesh N, Esser-Kahn AP. Improving the Adjuvanticity of Small Molecule Immune Potentiators Using Covalently Linked NF-?B Modulators. ACS Med Chem Lett. 2021 Sep 09; 12(9):1441-1448. PMID: 34527180.
      View in: PubMed
    6. Gao Y, Dearborn MA, Vyas S, Kumar A, Hemmer J, Wang Z, Wu Q, Alshangiti O, Moore JS, Esser-Kahn AP, Geubelle PH. Manipulating Frontal Polymerization and Instabilities with Phase-Changing Microparticles. J Phys Chem B. 2021 07 15; 125(27):7537-7545. PMID: 34228929.
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    7. Ayarza J, Wang Z, Wang J, Esser-Kahn AP. Mechanically Promoted Synthesis of Polymer Organogels via Disulfide Bond Cross-Linking. ACS Macro Lett. 2021 07 20; 10(7):799-804. PMID: 35549197.
      View in: PubMed
    8. Nihesh N, Manna S, Studnitzer B, Shen J, Esser-Kahn AP. A synthetic pathogen mimetic molecule induces a highly amplified synergistic immune response via activation of multiple signaling pathways. Chem Sci. 2021 Apr 01; 12(19):6646-6651. PMID: 34040739.
      View in: PubMed
    9. Weiss AM, Ajit J, Albin TJ, Kapoor N, Maroju S, Berges A, Pill L, Fairman J, Esser-Kahn AP. Site-specific antigen-adjuvant conjugation using cell-free protein synthesis enhances antigen presentation and CD8+ T-cell response. Sci Rep. 2021 03 18; 11(1):6267. PMID: 33737644.
      View in: PubMed
    10. Fratzke AP, Jan S, Felgner J, Liang L, Nakajima R, Jasinskas A, Manna S, Nihesh FN, Maiti S, Albin TJ, Esser-Kahn AP, Davies DH, Samuel JE, Felgner PL, Gregory AE. Subunit Vaccines Using TLR Triagonist Combination Adjuvants Provide Protection Against Coxiella burnetii While Minimizing Reactogenic Responses. Front Immunol. 2021; 12:653092. PMID: 33815413.
      View in: PubMed
    11. Weiss AM, Macke N, Zhang Y, Calvino C, Esser-Kahn AP, Rowan SJ. In Vitro and in Vivo Analyses of the Effects of Source, Length, and Charge on the Cytotoxicity and Immunocompatibility of Cellulose Nanocrystals. ACS Biomater Sci Eng. 2021 04 12; 7(4):1450-1461. PMID: 33689287.
      View in: PubMed
    12. Wang Z, Wang J, Ayarza J, Steeves T, Hu Z, Manna S, Esser-Kahn AP. Bio-inspired mechanically adaptive materials through vibration-induced crosslinking. Nat Mater. 2021 06; 20(6):869-874. PMID: 33619367.
      View in: PubMed
    13. Steeves TM, Esser-Kahn AP. Demonstration of the photothermal catalysis of the Sabatier reaction using nickel nanoparticles and solar spectrum light. RSC Adv. 2021 Feb 17; 11(14):8394-8397. PMID: 35423330.
      View in: PubMed
    14. Kimani FW, Ajit J, Galluppi A, Manna S, Howitz WJ, Tang S, Esser-Kahn AP. Receptor-Ligand Kinetics Influence the Mechanism of Action of Covalently Linked TLR Ligands. ACS Chem Biol. 2021 02 19; 16(2):380-388. PMID: 33523635.
      View in: PubMed
    15. Manna S, Maiti S, Shen J, Du W, Esser-Kahn AP. Pathogen-like Nanoassemblies of Covalently Linked TLR Agonists Enhance CD8 and NK Cell-Mediated Antitumor Immunity. ACS Cent Sci. 2020 Nov 25; 6(11):2071-2078. PMID: 33274283.
      View in: PubMed
    16. Moser BA, Escalante-Buendia Y, Steinhardt RC, Rosenberger MG, Cassaidy BJ, Naorem N, Chon AC, Nguyen MH, Tran NT, Esser-Kahn AP. Small Molecule NF-?B Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants. Front Immunol. 2020; 11:511513. PMID: 33072085.
      View in: PubMed
    17. Moser BA, Steinhardt RC, Escalante-Buendia Y, Boltz DA, Barker KM, Cassaidy BJ, Rosenberger MG, Yoo S, McGonnigal BG, Esser-Kahn AP. Increased vaccine tolerability and protection via NF-?B modulation. Sci Adv. 2020 09; 6(37). PMID: 32917696.
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    18. Maiti S, Manna S, Banahene N, Pham L, Liang Z, Wang J, Xu Y, Bettinger R, Zientko J, Esser-Kahn AP, Du W. From Glucose to Polymers: A Continuous Chemoenzymatic Process. Angew Chem Int Ed Engl. 2020 10 19; 59(43):18943-18947. PMID: 33448568.
      View in: PubMed
    19. Ayarza J, Wang Z, Wang J, Huang CW, Esser-Kahn AP. 100th Anniversary of Macromolecular Science Viewpoint: Piezoelectrically Mediated Mechanochemical Reactions for Adaptive Materials. ACS Macro Lett. 2020 Sep 15; 9(9):1237-1248. PMID: 35638625.
      View in: PubMed
    20. Deak P, Kimani F, Cassaidy B, Esser-Kahn A. Determining Whether Agonist Density or Agonist Number Is More Important for Immune Activation via Micoparticle Based Assay. Front Immunol. 2020; 11:642. PMID: 32328073.
      View in: PubMed
    21. Gilkes AP, Albin TJ, Manna S, Supnet M, Ruiz S, Tom J, Badten AJ, Jain A, Nakajima R, Felgner J, Davies DH, Stetkevich SA, Zlotnik A, Pearlman E, Nalca A, Felgner PL, Esser-Kahn AP, Burkhardt AM. Tuning Subunit Vaccines with Novel TLR Triagonist Adjuvants to Generate Protective Immune Responses against Coxiella burnetii. J Immunol. 2020 02 01; 204(3):611-621. PMID: 31871024.
      View in: PubMed
    22. Wu M, Moser BA, Steeves TM, Figueroa A, Wallace BM, Kim ST, Esser-Kahn AP, Steinhardt RC. Photon upconversion for the enhancement of microfluidic photochemical synthesis. RSC Adv. 2019 Aug 19; 9(45):26172-26175. PMID: 35531036.
      View in: PubMed
    23. Wang Z, Ayarza J, Esser-Kahn AP. Mechanically Initiated Bulk-Scale Free-Radical Polymerization. Angew Chem Int Ed Engl. 2019 Aug 26; 58(35):12023-12026. PMID: 31267620.
      View in: PubMed
    24. Albin TJ, Tom JK, Manna S, Gilkes AP, Stetkevich SA, Katz BB, Supnet M, Felgner J, Jain A, Nakajima R, Jasinskas A, Zlotnik A, Pearlman E, Davies DH, Felgner PL, Burkhardt AM, Esser-Kahn AP. Linked Toll-Like Receptor Triagonists Stimulate Distinct, Combination-Dependent Innate Immune Responses. ACS Cent Sci. 2019 Jul 24; 5(7):1137-1145. PMID: 31403067.
      View in: PubMed
    25. Kimani F, Kim SM, Steinhardt R, Esser-Kahn AP. Correlating the structure and reactivity of a contact allergen, DNCB, and its analogs to sensitization potential. Bioorg Med Chem. 2019 07 01; 27(13):2985-2990. PMID: 31128992.
      View in: PubMed
    26. Maiti S, Manna S, Shen J, Esser-Kahn AP, Du W. Mitigation of Hydrophobicity-Induced Immunotoxicity by Sugar Poly(orthoesters). J Am Chem Soc. 2019 03 20; 141(11):4510-4514. PMID: 30768257.
      View in: PubMed
    27. Tom JK, Albin TJ, Manna S, Moser BA, Steinhardt RC, Esser-Kahn AP. Applications of Immunomodulatory Immune Synergies to Adjuvant Discovery and Vaccine Development. Trends Biotechnol. 2019 04; 37(4):373-388. PMID: 30470547.
      View in: PubMed
    28. Manna S, Howitz WJ, Oldenhuis NJ, Eldredge AC, Shen J, Nihesh FN, Lodoen MB, Guan Z, Esser-Kahn AP. Correction to "Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture". ACS Cent Sci. 2018 11 28; 4(11):1593. PMID: 30555913.
      View in: PubMed
    29. Mohapatra H, Ayarza J, Sanders EC, Scheuermann AM, Griffin PJ, Esser-Kahn AP. Ultrasound Promoted Step-Growth Polymerization and Polymer Crosslinking Via Copper Catalyzed Azide-Alkyne "Click" Reaction. Angew Chem Int Ed Engl. 2018 Aug 27; 57(35):11208-11212. PMID: 29992680.
      View in: PubMed
    30. Manna S, Howitz WJ, Oldenhuis NJ, Eldredge AC, Shen J, Nihesh FN, Lodoen MB, Guan Z, Esser-Kahn AP. Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture. ACS Cent Sci. 2018 Aug 22; 4(8):982-995. PMID: 30159395.
      View in: PubMed
    31. Brubaker K, Garewal A, Steinhardt RC, Esser-Kahn AP. Bio-inspired counter-current multiplier for enrichment of solutes. Nat Commun. 2018 02 21; 9(1):736. PMID: 29467391.
      View in: PubMed
    32. Ignacio BJ, Albin TJ, Esser-Kahn AP, Verdoes M. Toll-like Receptor Agonist Conjugation: A Chemical Perspective. Bioconjug Chem. 2018 03 21; 29(3):587-603. PMID: 29378134.
      View in: PubMed
    33. Esser-Kahn AP. Kiss-and-tell way to track cell contacts. Nature. 2018 01 25; 553(7689):414-415. PMID: 29368706.
      View in: PubMed
    34. Esser-Kahn AP. Kiss-and-tell way to track cell contacts. Nature. 2018 Jan; 553(7689):414-415. PMID: 32094788.
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    35. Van Herck S, Van Hoecke L, Louage B, Lybaert L, De Coen R, Kasmi S, Esser-Kahn AP, David SA, Nuhn L, Schepens B, Saelens X, De Geest BG. Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as a Vaccine Adjuvant. Bioconjug Chem. 2018 03 21; 29(3):748-760. PMID: 29172458.
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    36. Steinhardt R, Hiew SC, Mohapatra H, Nguyen D, Oh Z, Truong R, Esser-Kahn A. Cooperative CO2 Absorption Isotherms from a Bifunctional Guanidine and Bifunctional Alcohol. ACS Cent Sci. 2017 Dec 27; 3(12):1271-1275. PMID: 29296667.
      View in: PubMed
    37. Steinhardt RC, Steeves TM, Wallace BM, Moser B, Fishman DA, Esser-Kahn AP. Photothermal Nanoparticle Initiation Enables Radical Polymerization and Yields Unique, Uniform Microfibers with Broad Spectrum Light. ACS Appl Mater Interfaces. 2017 Nov 08; 9(44):39034-39039. PMID: 29040810.
      View in: PubMed
    38. Ryu KA, McGonnigal B, Moore T, Kargupta T, Mancini RJ, Esser-Kahn AP. Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist. Sci Rep. 2017 08 14; 7(1):8074. PMID: 28808328.
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    39. Lybaert L, Ryu KA, De Rycke R, Chon AC, De Wever O, Vermaelen KY, Esser-Kahn A, De Geest BG. Polyelectrolyte-Enrobed Cancer Cells in View of Personalized Immune-Therapy. Adv Sci (Weinh). 2017 06; 4(6):1700050. PMID: 28638786.
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    40. Moser BA, Esser-Kahn AP. A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation. ACS Chem Biol. 2017 02 17; 12(2):347-350. PMID: 28000442.
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    41. Moser BA, Steinhardt RC, Esser-Kahn AP. Surface Coating of Nanoparticles Reduces Background Inflammatory Activity while Increasing Particle Uptake and Delivery. ACS Biomater Sci Eng. 2017 Feb 13; 3(2):206-213. PMID: 28936479.
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    42. Esser-Kahn AP, Sottos NR, White SR, Moore JS. Correction to "Programmable Microcapsules from Self-Immolative Polymers. J Am Chem Soc. 2016 12 14; 138(49):16182. PMID: 27960329.
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    43. Ryu KA, Slowinska K, Moore T, Esser-Kahn A. Immune Response Modulation of Conjugated Agonists with Changing Linker Length. ACS Chem Biol. 2016 12 16; 11(12):3347-3352. PMID: 27749034.
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    44. Nguyen D, Stolaroff J, Esser-Kahn A. Solvent Effects on the Photothermal Regeneration of CO2 in Monoethanolamine Nanofluids. ACS Appl Mater Interfaces. 2015 Nov 25; 7(46):25851-6. PMID: 26523847.
      View in: PubMed
    45. Tom JK, Dotsey EY, Wong HY, Stutts L, Moore T, Davies DH, Felgner PL, Esser-Kahn AP. Modulation of Innate Immune Responses via Covalently Linked TLR Agonists. ACS Cent Sci. 2015 Nov 25; 1(8):439-448. PMID: 26640818.
      View in: PubMed
    46. Lynn GM, Laga R, Darrah PA, Ishizuka AS, Balaci AJ, Dulcey AE, Pechar M, Pola R, Gerner MY, Yamamoto A, Buechler CR, Quinn KM, Smelkinson MG, Vanek O, Cawood R, Hills T, Vasalatiy O, Kastenmüller K, Francica JR, Stutts L, Tom JK, Ryu KA, Esser-Kahn AP, Etrych T, Fisher KD, Seymour LW, Seder RA. In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity. Nat Biotechnol. 2015 Nov; 33(11):1201-10. PMID: 26501954.
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    47. Stutts L, Esser-Kahn AP. A Light-Controlled TLR4 Agonist and Selectable Activation of Cell Subpopulations. Chembiochem. 2015 Aug 17; 16(12):1744-8. PMID: 26097006.
      View in: PubMed
    48. Mancini RJ, Stutts L, Moore T, Esser-Kahn AP. Controlling the origins of inflammation with a photoactive lipopeptide immunopotentiator. Angew Chem Int Ed Engl. 2015 May 11; 54(20):5962-5. PMID: 25800006.
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    49. Ryu KA, Stutts L, Tom JK, Mancini RJ, Esser-Kahn AP. Stimulation of innate immune cells by light-activated TLR7/8 agonists. J Am Chem Soc. 2014 Aug 06; 136(31):10823-5. PMID: 25029205.
      View in: PubMed
    50. Mancini RJ, Stutts L, Ryu KA, Tom JK, Esser-Kahn AP. Directing the immune system with chemical compounds. ACS Chem Biol. 2014 May 16; 9(5):1075-85. PMID: 24690004.
      View in: PubMed
    51. Nguyen du T, Kleiman M, Ryu KA, Hiew S, Brubaker K, Mughnetsyan R, Truong R, Dolan B, Tackett E, Esser-Kahn AP. Three-dimensional conformal coatings through the entrapment of polymer membrane precursors. ACS Appl Mater Interfaces. 2014 Feb 26; 6(4):2830-5. PMID: 24437474.
      View in: PubMed
    52. Mancini RJ, Tom JK, Esser-Kahn AP. Covalently coupled immunostimulant heterodimers. Angew Chem Int Ed Engl. 2014 Jan 03; 53(1):189-92. PMID: 24259411.
      View in: PubMed
    53. Nguyen du T, Esser-Kahn AP. A microvascular system for chemical reactions using surface waste heat. Angew Chem Int Ed Engl. 2013 Dec 16; 52(51):13731-4. PMID: 24307247.
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    54. Nguyen du T, Leho YT, Esser-Kahn AP. Process of making three-dimensional microstructures using vaporization of a sacrificial component. J Vis Exp. 2013 Nov 02; (81):e50459. PMID: 24300342.
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    55. Tom JK, Mancini RJ, Esser-Kahn AP. Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation. Chem Commun (Camb). 2013 Oct 25; 49(83):9618-20. PMID: 24022092.
      View in: PubMed
    56. Nguyen du T, Leho YT, Esser-Kahn AP. A three-dimensional microvascular gas exchange unit for carbon dioxide capture. Lab Chip. 2012 Apr 07; 12(7):1246-50. PMID: 22344348.
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    57. Dong H, Esser-Kahn AP, Thakre PR, Patrick JF, Sottos NR, White SR, Moore JS. Chemical treatment of poly(lactic acid) fibers to enhance the rate of thermal depolymerization. ACS Appl Mater Interfaces. 2012 Feb; 4(2):503-9. PMID: 22008224.
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    58. Esser-Kahn AP, Thakre PR, Dong H, Patrick JF, Vlasko-Vlasov VK, Sottos NR, Moore JS, White SR. Three-dimensional microvascular fiber-reinforced composites. Adv Mater. 2011 Aug 23; 23(32):3654-8. PMID: 21766345.
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    59. Witus LS, Moore T, Thuronyi BW, Esser-Kahn AP, Scheck RA, Iavarone AT, Francis MB. Identification of highly reactive sequences for PLP-mediated bioconjugation using a combinatorial peptide library. J Am Chem Soc. 2010 Dec 01; 132(47):16812-7. PMID: 21067189.
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    60. Esser-Kahn AP, Trang V, Francis MB. Incorporation of antifreeze proteins into polymer coatings using site-selective bioconjugation. J Am Chem Soc. 2010 Sep 29; 132(38):13264-9. PMID: 20825180.
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    61. Esser-Kahn AP, Sottos NR, White SR, Moore JS. Programmable microcapsules from self-immolative polymers. J Am Chem Soc. 2010 Aug 04; 132(30):10266-8. PMID: 20662509.
      View in: PubMed
    62. Esser-Kahn AP, Iavarone AT, Francis MB. Metallothionein-cross-linked hydrogels for the selective removal of heavy metals from water. J Am Chem Soc. 2008 Nov 26; 130(47):15820-2. PMID: 18980305.
      View in: PubMed
    63. Esser-Kahn AP, Francis MB. Protein-cross-linked polymeric materials through site-selective bioconjugation. Angew Chem Int Ed Engl. 2008; 47(20):3751-4. PMID: 18399554.
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    64. Hooker JM, Esser-Kahn AP, Francis MB. Modification of aniline containing proteins using an oxidative coupling strategy. J Am Chem Soc. 2006 Dec 13; 128(49):15558-9. PMID: 17147343.
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    65. Gilmore JM, Scheck RA, Esser-Kahn AP, Joshi NS, Francis MB. N-terminal protein modification through a biomimetic transamination reaction. Angew Chem Int Ed Engl. 2006 Aug 11; 45(32):5307-11. PMID: 16847857.
      View in: PubMed
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