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Boris Reizis

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine-Rheumatology
AddressChicago IL 60637
ORCID ORCID Icon0000-0003-1140-7853 Additional info
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    Dr. Reizis joined UChicago in October 2025 from NYU Langone Grossman School of Medicine, where he has been the Samuel A. Brown Professor of Medicine and a founding director of the Translational Immunology Center. His lab is studying fundamental mechanisms of immune system development, immunological tolerance and autoimmunity.

    One major area of research is dendritic cells (DCs), innate sentinel cells that comprise the antigen-presenting classical DCs (cDCs) and interferon-producing plasmacytoid DC (pDCs). The Reizis lab has identified several key transcriptional regulators and signaling pathways that control the DC lineage, such as the "master regulator" of pDC development (Tcf4/E2-2), the driver of cDC differentiation in the periphery (Notch2) and the developmental “pan-DC” regulator (Trim33). These genetic insights are used to better characterize the role of DCs in immune response to infections, immune homeostasis and autoimmunity.

    The lab also studies systemic autoimmune diseases such as systemic lupus erythematosus (SLE), which is characterized by autoreactivity to nuclear antigens including ribonucleoproteins and DNA. Of particular interest are antibody responses to self DNA, which are prevalent and pathogenic in SLE. The lab has defined the extracellular nuclease DNASE1L3 as an essential gatekeeper of tolerance to self-DNA, and revealed its autoantibody-mediated blockade in more than half of human patients with severe SLE. Current studies include the mechanisms that cause the breakdown of tolerance and propagation of autoreactivity in SLE and its animal models.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pucella JN, Maqueda-Alfaro RA, Ni H, Bandeira Sulczewski F, Eichinger A, Esteva E, Ra AC, Das A, Perez OA, Feng J, Stoeckius M, Smibert P, Khodadadi-Jamayran A, Dolgalev I, Ivanova E, Sota S, Cadwell K, Koralov SB, Zhong J, Soni C, Stetson DB, Weisberg SP, Farber DL, Idoyaga J, Reizis B. Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells. Nat Immunol. 2025 Oct 14. PMID: 41087726.
      Citations:    
    2. Saglimbeni J, Esteva E, Canales J, Perez OA, Eichinger A, Huntley W, Khanna KM, Dolgalev I, Klar N, Adams S, Reizis B. Peritumoral macrophages recruit eosinophils to promote antitumor immune responses in breast cancer. Proc Natl Acad Sci U S A. 2025 Sep 23; 122(38):e2504645122. PMID: 40953260; PMCID: PMC12478179.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Jang G, Park R, Esteva E, Hsu PF, Feng J, Upadhaya S, Sawai CM, Aifantis I, Fooksman DR, Reizis B. Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system. J Exp Med. 2025 Jun 02; 222(6). PMID: 40072317; PMCID: PMC11899982.
      Citations:    Fields:    Translation:AnimalsCells
    4. Adams NM, Das A, Yun TJ, Reizis B. Ontogeny and Function of Plasmacytoid Dendritic Cells. Annu Rev Immunol. 2024 Jun; 42(1):347-373. PMID: 38941603.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    5. Tiniakou I, Hsu PF, Lopez-Zepeda LS, Garipler G, Esteva E, Adams NM, Jang G, Soni C, Lau CM, Liu F, Khodadadi-Jamayran A, Rodrick TC, Jones D, Tsirigos A, Ohler U, Bedford MT, Nimer SD, Kaartinen V, Mazzoni EO, Reizis B. Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation. Sci Immunol. 2024 04 12; 9(94):eadi1023. PMID: 38608038; PMCID: PMC11182672.
      Citations: 3     Fields:    Translation:Cells
    6. Feng J, Jang G, Esteva E, Adams NM, Jin H, Reizis B. Clonal barcoding of endogenous adult hematopoietic stem cells reveals a spectrum of lineage contributions. Proc Natl Acad Sci U S A. 2024 Jan 23; 121(4):e2317929121. PMID: 38227649; PMCID: PMC10823160.
      Citations: 4     Fields:    Translation:AnimalsCells
    7. Soni C, Makita S, Eichinger A, Serpas L, Sisirak V, Reizis B. Cutting Edge: TLR2 Signaling in B Cells Promotes Autoreactivity to DNA via IL-6 Secretion. J Immunol. 2023 11 15; 211(10):1475-1480. PMID: 37800687; PMCID: PMC10841863.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    8. Feng J, Hsu PF, Esteva E, Labella R, Wang Y, Khodadadi-Jamayran A, Pucella J, Liu CZ, Arbini AA, Tsirigos A, Kousteni S, Reizis B. Haplodeficiency of the 9p21 tumor suppressor locus causes myeloid disorders driven by the bone marrow microenvironment. Blood. 2023 08 03; 142(5):460-476. PMID: 37267505; PMCID: PMC12022840.
      Citations: 3     Fields:    Translation:AnimalsCells
    9. Sulczewski FB, Maqueda-Alfaro RA, Alcántara-Hernández M, Perez OA, Saravanan S, Yun TJ, Seong D, Arroyo Hornero R, Raquer-McKay HM, Esteva E, Lanzar ZR, Leylek RA, Adams NM, Das A, Rahman AH, Gottfried-Blackmore A, Reizis B, Idoyaga J. Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses. Nat Immunol. 2023 08; 24(8):1265-1280. PMID: 37414907; PMCID: PMC10683792.
      Citations: 33     Fields:    Translation:AnimalsCells
    10. Jang G, Contreras Castillo S, Esteva E, Upadhaya S, Feng J, Adams NM, Richard E, Awatramani R, Sawai CM, Reizis B. Stem cell decoupling underlies impaired lymphoid development during aging. Proc Natl Acad Sci U S A. 2023 05 30; 120(22):e2302019120. PMID: 37216517; PMCID: PMC10236001.
      Citations: 4     Fields:    Translation:AnimalsCells
    11. Lacey KA, Serpas L, Makita S, Wang Y, Rashidfarrokhi A, Soni C, Gonzalez S, Moreira A, Torres VJ, Reizis B. Secreted mammalian DNases protect against systemic bacterial infection by digesting biofilms. J Exp Med. 2023 06 05; 220(6). PMID: 36928522; PMCID: PMC10037111.
      Citations: 15     Fields:    Translation:AnimalsCells
    12. Feng J, Pucella JN, Jang G, Alcántara-Hernández M, Upadhaya S, Adams NM, Khodadadi-Jamayran A, Lau CM, Stoeckius M, Hao S, Smibert P, Tsirigos A, Idoyaga J, Reizis B. Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells. Immunity. 2022 03 08; 55(3):405-422.e11. PMID: 35180378; PMCID: PMC9344860.
      Citations: 46     Fields:    Translation:AnimalsCells
    13. Hartl J, Serpas L, Wang Y, Rashidfarrokhi A, Perez OA, Sally B, Sisirak V, Soni C, Khodadadi-Jamayran A, Tsirigos A, Caiello I, Bracaglia C, Volpi S, Ghiggeri GM, Chida AS, Sanz I, Kim MY, Belmont HM, Silverman GJ, Clancy RM, Izmirly PM, Buyon JP, Reizis B. Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus. J Exp Med. 2021 05 03; 218(5). PMID: 33783474; PMCID: PMC8020718.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    14. Yun TJ, Igarashi S, Zhao H, Perez OA, Pereira MR, Zorn E, Shen Y, Goodrum F, Rahman A, Sims PA, Farber DL, Reizis B. Human plasmacytoid dendritic cells mount a distinct antiviral response to virus-infected cells. Sci Immunol. 2021 04 02; 6(58). PMID: 33811059; PMCID: PMC8221820.
      Citations: 35     Fields:    Translation:HumansCells
    15. Upadhaya S, Krichevsky O, Akhmetzyanova I, Sawai CM, Fooksman DR, Reizis B. Intravital Imaging Reveals Motility of Adult Hematopoietic Stem Cells in the Bone Marrow Niche. Cell Stem Cell. 2020 08 06; 27(2):336-345.e4. PMID: 32589864; PMCID: PMC7415613.
      Citations: 40     Fields:    Translation:AnimalsCells
    16. Pucella JN, Upadhaya S, Reizis B. The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing. Annu Rev Cell Dev Biol. 2020 10 06; 36:529-550. PMID: 32580566.
      Citations: 30     Fields:    Translation:HumansCells
    17. Soni C, Perez OA, Voss WN, Pucella JN, Serpas L, Mehl J, Ching KL, Goike J, Georgiou G, Ippolito GC, Sisirak V, Reizis B. Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA. Immunity. 2020 06 16; 52(6):1022-1038.e7. PMID: 32454024; PMCID: PMC7306002.
      Citations: 92     Fields:    Translation:AnimalsCells
    18. Reizis B. Plasmacytoid Dendritic Cells: Development, Regulation, and Function. Immunity. 2019 01 15; 50(1):37-50. PMID: 30650380; PMCID: PMC6342491.
      Citations: 345     Fields:    Translation:HumansAnimalsCells
    19. Upadhaya S, Sawai CM, Papalexi E, Rashidfarrokhi A, Jang G, Chattopadhyay P, Satija R, Reizis B. Kinetics of adult hematopoietic stem cell differentiation in vivo. J Exp Med. 2018 11 05; 215(11):2815-2832. PMID: 30291161; PMCID: PMC6219744.
      Citations: 39     Fields:    Translation:AnimalsCells
    20. Soni C, Reizis B. DNA as a self-antigen: nature and regulation. Curr Opin Immunol. 2018 12; 55:31-37. PMID: 30261321; PMCID: PMC6317730.
      Citations: 21     Fields:    Translation:Humans
    21. Lau CM, Tiniakou I, Perez OA, Kirkling ME, Yap GS, Hock H, Reizis B. Transcription factor Etv6 regulates functional differentiation of cross-presenting classical dendritic cells. J Exp Med. 2018 09 03; 215(9):2265-2278. PMID: 30087163; PMCID: PMC6122974.
      Citations: 20     Fields:    Translation:AnimalsCells
    22. Kirkling ME, Cytlak U, Lau CM, Lewis KL, Resteu A, Khodadadi-Jamayran A, Siebel CW, Salmon H, Merad M, Tsirigos A, Collin M, Bigley V, Reizis B. Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells. Cell Rep. 2018 06 19; 23(12):3658-3672.e6. PMID: 29925006; PMCID: PMC6063084.
      Citations: 105     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    23. Grajkowska LT, Ceribelli M, Lau CM, Warren ME, Tiniakou I, Nakandakari Higa S, Bunin A, Haecker H, Mirny LA, Staudt LM, Reizis B. Isoform-Specific Expression and Feedback Regulation of E Protein TCF4 Control Dendritic Cell Lineage Specification. Immunity. 2017 01 17; 46(1):65-77. PMID: 27986456; PMCID: PMC5243153.
      Citations: 59     Fields:    Translation:AnimalsCells
    24. Sawai CM, Babovic S, Upadhaya S, Knapp DJHF, Lavin Y, Lau CM, Goloborodko A, Feng J, Fujisaki J, Ding L, Mirny LA, Merad M, Eaves CJ, Reizis B. Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals. Immunity. 2016 09 20; 45(3):597-609. PMID: 27590115; PMCID: PMC5054720.
      Citations: 217     Fields:    Translation:AnimalsCells
    25. Sisirak V, Sally B, D'Agati V, Martinez-Ortiz W, Özçakar ZB, David J, Rashidfarrokhi A, Yeste A, Panea C, Chida AS, Bogunovic M, Ivanov II, Quintana FJ, Sanz I, Elkon KB, Tekin M, Yalçinkaya F, Cardozo TJ, Clancy RM, Buyon JP, Reizis B. Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity. Cell. 2016 Jun 30; 166(1):88-101. PMID: 27293190; PMCID: PMC5030815.
      Citations: 256     Fields:    Translation:HumansAnimalsCells
    26. Lau CM, Nish SA, Yogev N, Waisman A, Reiner SL, Reizis B. Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses. J Exp Med. 2016 Mar 07; 213(3):415-31. PMID: 26903243; PMCID: PMC4813676.
      Citations: 36     Fields:    Translation:AnimalsCells
    27. Bunin A, Sisirak V, Ghosh HS, Grajkowska LT, Hou ZE, Miron M, Yang C, Ceribelli M, Uetani N, Chaperot L, Plumas J, Hendriks W, Tremblay ML, Häcker H, Staudt LM, Green PH, Bhagat G, Reizis B. Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells. Immunity. 2015 Aug 18; 43(2):277-88. PMID: 26231120; PMCID: PMC4547994.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    28. Sisirak V, Ganguly D, Lewis KL, Couillault C, Tanaka L, Bolland S, D'Agati V, Elkon KB, Reizis B. Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus. J Exp Med. 2014 Sep 22; 211(10):1969-76. PMID: 25180061; PMCID: PMC4172218.
      Citations: 138     Fields:    Translation:AnimalsCells
    29. Ghosh HS, Ceribelli M, Matos I, Lazarovici A, Bussemaker HJ, Lasorella A, Hiebert SW, Liu K, Staudt LM, Reizis B. ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2. J Exp Med. 2014 Jul 28; 211(8):1623-35. PMID: 24980046; PMCID: PMC4113936.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    30. Sawai CM, Sisirak V, Ghosh HS, Hou EZ, Ceribelli M, Staudt LM, Reizis B. Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells. J Exp Med. 2013 Oct 21; 210(11):2151-9. PMID: 24101375; PMCID: PMC3804932.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    31. Ganguly D, Haak S, Sisirak V, Reizis B. The role of dendritic cells in autoimmunity. Nat Rev Immunol. 2013 Aug; 13(8):566-77. PMID: 23827956; PMCID: PMC4160805.
      Citations: 248     Fields:    Translation:HumansAnimalsCells
    32. Cervantes-Barragan L, Lewis KL, Firner S, Thiel V, Hugues S, Reith W, Ludewig B, Reizis B. Plasmacytoid dendritic cells control T-cell response to chronic viral infection. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3012-7. PMID: 22315415; PMCID: PMC3286988.
      Citations: 132     Fields:    Translation:AnimalsCells
    33. Lewis KL, Caton ML, Bogunovic M, Greter M, Grajkowska LT, Ng D, Klinakis A, Charo IF, Jung S, Gommerman JL, Ivanov II, Liu K, Merad M, Reizis B. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity. 2011 Nov 23; 35(5):780-91. PMID: 22018469; PMCID: PMC3225703.
      Citations: 286     Fields:    Translation:AnimalsCells
    34. Ghosh HS, Cisse B, Bunin A, Lewis KL, Reizis B. Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells. Immunity. 2010 Dec 14; 33(6):905-16. PMID: 21145760; PMCID: PMC3010277.
      Citations: 157     Fields:    Translation:AnimalsCells
    35. Sathaliyawala T, O'Gorman WE, Greter M, Bogunovic M, Konjufca V, Hou ZE, Nolan GP, Miller MJ, Merad M, Reizis B. Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling. Immunity. 2010 Oct 29; 33(4):597-606. PMID: 20933441; PMCID: PMC2966531.
      Citations: 97     Fields:    Translation:AnimalsCells
    36. Cisse B, Caton ML, Lehner M, Maeda T, Scheu S, Locksley R, Holmberg D, Zweier C, den Hollander NS, Kant SG, Holter W, Rauch A, Zhuang Y, Reizis B. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell. 2008 Oct 03; 135(1):37-48. PMID: 18854153; PMCID: PMC2631034.
      Citations: 357     Fields:    Translation:HumansAnimalsCells
    37. Caton ML, Smith-Raska MR, Reizis B. Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen. J Exp Med. 2007 Jul 09; 204(7):1653-64. PMID: 17591855; PMCID: PMC2118632.
      Citations: 505     Fields:    Translation:AnimalsCells
    38. Galan-Caridad JM, Harel S, Arenzana TL, Hou ZE, Doetsch FK, Mirny LA, Reizis B. Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell. 2007 Apr 20; 129(2):345-57. PMID: 17448993; PMCID: PMC1899089.
      Citations: 134     Fields:    Translation:AnimalsCells
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