Andrew Koh
Title | Assistant Professor |
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Institution | University of Chicago |
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Department | Pathology |
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Address | Chicago IL 60637
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Phone | +1 (773) 8345702 |
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Email |  |
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vCard | Download vCard |
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Overview Immune defense requires the capacity to respond to ever-changing pathogens and cancers while remaining tolerant to self. The Koh lab focuses on understanding the design principles in immune development that allow flexibility in cellular fate and function, and how these mechanisms are subverted in human disease. A major emphasis is to identify determinants that allow thymic epithelia to ectopically express thousands of tissue-specific self-antigens (e.g. insulin) to promote tolerance against harmful self-reactive T cells and prevent autoimmunity (e.g. diabetes). Another focus is to understand how T cells acquire competence to deploy diverse arrays of effector functions, and how this plasticity relates to leukemogenesis. We employ a broad, interdisciplinary approach combining genetics, genomics, biochemistry and proteomics, with particular investment in developing multi-omics methods to interrogate chromatin accessibility, gene expression, and cell-surface proteins from the same single cell. Elucidating how cellular plasticity is programmed in development, and dysregulated in disease, will avail novel therapeutic avenues for human disorders.
Biography University of California, Los Angeles | BS | 2003 | Molecular, Cell and Developmental Biology | Harvard University | PhD | 2010 | Immunology | Stanford University | Postdoc | 2018 | Chromatin Remodeling |
2011 - 2014 | Leukemia & Lymphoma Society Fellow | 2006 - 2007 | Certificate of Excellence and Distinction in Teaching, Harvard College | 2006 - 2008 | NIH Ruth L. Kirschstein National Research Service Award |
ORNG Applications Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Koh AS, Miller EL, Buenrostro JD, Moskowitz DM, Wang J, Greenleaf WJ, Chang HY, Crabtree GR. Rapid chromatin repression by Aire provides precise control of immune tolerance. Nat Immunol. 2018 02; 19(2):162-172. PMID: 29335648.
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Koh AS, Kingston RE, Benoist C, Mathis D. Global relevance of Aire binding to hypomethylated lysine-4 of histone-3. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13016-21. PMID: 20615959.
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Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D, Shoelson SE, Gozani O, Kingston RE, Benoist C, Mathis D. Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):15878-83. PMID: 18840680.
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Year | Publications |
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2008 | 1 | 2010 | 1 | 2018 | 1 |
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