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Andrew Koh

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentPathology
AddressChicago IL 60637
Phone+1 (773) 8345702
Email
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    Collapse Overview 
    Collapse overview
    Immune defense requires the capacity to respond to ever-changing pathogens and cancers while remaining tolerant to self. The Koh lab focuses on understanding the design principles in immune development that allow flexibility in cellular fate and function, and how these mechanisms are subverted in human disease. A major emphasis is to identify determinants that allow thymic epithelia to ectopically express thousands of tissue-specific self-antigens (e.g. insulin) to promote tolerance against harmful self-reactive T cells and prevent autoimmunity (e.g. diabetes). Another focus is to understand how T cells acquire competence to deploy diverse arrays of effector functions, and how this plasticity relates to leukemogenesis. We employ a broad, interdisciplinary approach combining genetics, genomics, biochemistry and proteomics, with particular investment in developing multi-omics methods to interrogate chromatin accessibility, gene expression, and cell-surface proteins from the same single cell. Elucidating how cellular plasticity is programmed in development, and dysregulated in disease, will avail novel therapeutic avenues for human disorders.
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    Collapse Biography 
    Collapse education and training
    University of California, Los AngelesBS2003Molecular, Cell and Developmental Biology
    Harvard UniversityPhD2010Immunology
    Stanford UniversityPostdoc2018Chromatin Remodeling
    Collapse awards and honors
    2011 - 2014Leukemia & Lymphoma Society Fellow
    2006 - 2007Certificate of Excellence and Distinction in Teaching, Harvard College
    2006 - 2008NIH Ruth L. Kirschstein National Research Service Award

    Collapse Research 
    Collapse research activities and funding
    R35GM138150     (KOH, ANDREW S)Aug 1, 2020 - Jul 31, 2025
    NIH
    Epigenesis of Cell Fate Potential
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kaiser C, Bradu A, Gamble N, Caldwell JA, Koh AS. AIRE in context: Leveraging chromatin plasticity to trigger ectopic gene expression. Immunol Rev. 2022 01; 305(1):59-76. PMID: 34545959; PMCID: PMC9250823.
      Citations: 3     Fields:    Translation:HumansCells
    2. Koh AS, Miller EL, Buenrostro JD, Moskowitz DM, Wang J, Greenleaf WJ, Chang HY, Crabtree GR. Rapid chromatin repression by Aire provides precise control of immune tolerance. Nat Immunol. 2018 02; 19(2):162-172. PMID: 29335648; PMCID: PMC6049828.
      Citations: 24     Fields:    Translation:AnimalsCells
    3. Koh AS, Kingston RE, Benoist C, Mathis D. Global relevance of Aire binding to hypomethylated lysine-4 of histone-3. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13016-21. PMID: 20615959; PMCID: PMC2919944.
      Citations: 34     Fields:    Translation:AnimalsCells
    4. Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D, Shoelson SE, Gozani O, Kingston RE, Benoist C, Mathis D. Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):15878-83. PMID: 18840680; PMCID: PMC2572939.
      Citations: 90     Fields:    Translation:AnimalsCells
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