 Leukoencephalopathy, Progressive Multifocal
"Leukoencephalopathy, Progressive Multifocal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
| Descriptor ID |
D007968
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| MeSH Number(s) |
C02.182.500.300.500 C02.256.721.500 C02.290.575 C02.839.550 C10.228.140.695.750 C10.228.228.210.150.300.500 C10.228.228.245.340.575 C10.228.518.750 C10.314.450
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| Concept/Terms |
Leukoencephalopathy, Progressive Multifocal- Leukoencephalopathy, Progressive Multifocal
- Leukoencephalopathies, Progressive Multifocal
- Multifocal Leukoencephalopathies, Progressive
- Multifocal Leukoencephalopathy, Progressive
- Progressive Multifocal Leukoencephalopathies
- JC Polyomavirus Encephalopathy
- Encephalopathies, JC Polyomavirus
- Encephalopathy, JC Polyomavirus
- Progressive Multifocal Leukoencephalopathy
- Encephalitis, JC Polyomavirus
- JC Polyomavirus Encephalitis
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Below are MeSH descriptors whose meaning is more general than "Leukoencephalopathy, Progressive Multifocal".
- Diseases [C]
- Virus Diseases [C02]
- Central Nervous System Viral Diseases [C02.182]
- Encephalitis [C02.182.500]
- Encephalitis, Viral [C02.182.500.300]
- Leukoencephalopathy, Progressive Multifocal [C02.182.500.300.500]
- DNA Virus Infections [C02.256]
- Polyomavirus Infections [C02.256.721]
- Leukoencephalopathy, Progressive Multifocal [C02.256.721.500]
- Encephalitis, Viral [C02.290]
- Leukoencephalopathy, Progressive Multifocal [C02.290.575]
- Slow Virus Diseases [C02.839]
- Leukoencephalopathy, Progressive Multifocal [C02.839.550]
- Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
- Brain Diseases [C10.228.140]
- Leukoencephalopathies [C10.228.140.695]
- Leukoencephalopathy, Progressive Multifocal [C10.228.140.695.750]
- Central Nervous System Infections [C10.228.228]
- Central Nervous System Viral Diseases [C10.228.228.210]
- Encephalitis [C10.228.228.210.150]
- Encephalitis, Viral [C10.228.228.210.150.300]
- Leukoencephalopathy, Progressive Multifocal [C10.228.228.210.150.300.500]
- Encephalitis [C10.228.228.245]
- Encephalitis, Viral [C10.228.228.245.340]
- Leukoencephalopathy, Progressive Multifocal [C10.228.228.245.340.575]
- Leukoencephalopathies [C10.228.518]
- Leukoencephalopathy, Progressive Multifocal [C10.228.518.750]
- Demyelinating Diseases [C10.314]
- Leukoencephalopathy, Progressive Multifocal [C10.314.450]
Below are MeSH descriptors whose meaning is more specific than "Leukoencephalopathy, Progressive Multifocal".
This graph shows the total number of publications written about "Leukoencephalopathy, Progressive Multifocal" by people in this website by year, and whether "Leukoencephalopathy, Progressive Multifocal" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1983 | 0 | 1 | 1 | | 1986 | 0 | 1 | 1 | | 1988 | 0 | 1 | 1 | | 2001 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Leukoencephalopathy, Progressive Multifocal" by people in Profiles.
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Bellaguarda E, Sakuraba A. Reply. Clin Gastroenterol Hepatol. 2016 May; 14(5):776-7.
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Bellaguarda E, Keyashian K, Pekow J, Rubin DT, Cohen RD, Sakuraba A. Prevalence of Antibodies Against JC Virus in Patients With Refractory Crohn's Disease and Effects of Natalizumab Therapy. Clin Gastroenterol Hepatol. 2015 Nov; 13(11):1919-25.
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Feagan BG, Colombel JF, Hanauer SB, Parikh A, Rutgeerts P, Sandborn WJ, Sands BE. Comment on 'anti-adhesion therapies and the rule of 3 for rare events'. Am J Gastroenterol. 2014 Jul; 109(7):1083-4.
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Sandborn WJ, Colombel JF, Enns R, Feagan BG, Hanauer SB, Lawrance IC, Panaccione R, Sanders M, Schreiber S, Targan S, van Deventer S, Goldblum R, Despain D, Hogge GS, Rutgeerts P. Natalizumab induction and maintenance therapy for Crohn's disease. N Engl J Med. 2005 Nov 03; 353(18):1912-25.
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Shapiro RA, Mullane KM, Camras L, Flowers C, Sutton S. Clinical and magnetic resonance imaging regression of progressive multifocal leukoencephalopathy in an AIDS patient after intensive antiretroviral therapy. J Neuroimaging. 2001 Jul; 11(3):336-9.
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Karahalios D, Breit R, Dal Canto MC, Levy RM. Progressive multifocal leukoencephalopathy in patients with HIV infection: lack of impact of early diagnosis by stereotactic brain biopsy. J Acquir Immune Defic Syndr (1988). 1992 Oct; 5(10):1030-8.
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Ramsey RG, Geremia GK. CNS complications of AIDS: CT and MR findings. AJR Am J Roentgenol. 1988 Sep; 151(3):449-54.
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Schlitt MJ, Morawetz RB, Bonnin JM, Zeiger HE, Whitley RJ. Brain biopsy for encephalitis. Clin Neurosurg. 1986; 33:591-602.
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Roos RP. Viruses and demyelinating disease of the central nervous system. Neurol Clin. 1983 Aug; 1(3):681-700.
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Huckman MS, Fox JH, Ramsey RG. Computed tomography in the diagnosis of degenerative diseases of the brain. Semin Roentgenol. 1977 Jan; 12(1):63-75.
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