Immunoglobulin Switch Region
"Immunoglobulin Switch Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A site located in the INTRONS at the 5' end of each constant region segment of a immunoglobulin heavy-chain gene where recombination (or rearrangement) occur during IMMUNOGLOBULIN CLASS SWITCHING. Ig switch regions are found on genes encoding all five classes (IMMUNOGLOBULIN ISOTYPES) of IMMUNOGLOBULIN HEAVY CHAINS.
| Descriptor ID |
D007134
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| MeSH Number(s) |
G05.360.340.024.340.137.430 G05.360.340.024.340.335.300.500
|
| Concept/Terms |
Immunoglobulin Switch Region- Immunoglobulin Switch Region
- Ig Switch Sequences
- Ig Switch Sequence
- Sequence, Ig Switch
- Sequences, Ig Switch
- Switch Sequence, Ig
- Switch Sequences, Ig
- Switch Region, Immunoglobulin
- Immunoglobulin Switch Regions
- Region, Immunoglobulin Switch
- Regions, Immunoglobulin Switch
- Switch Regions, Immunoglobulin
|
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Switch Region".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Switch Region".
This graph shows the total number of publications written about "Immunoglobulin Switch Region" by people in this website by year, and whether "Immunoglobulin Switch Region" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "Immunoglobulin Switch Region" by people in Profiles.
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Immunology. Double TIP-ping. Science. 2010 Aug 20; 329(5994):914-5.
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S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination. J Exp Med. 2009 Aug 03; 206(8):1817-30.
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The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription. J Exp Med. 2009 May 11; 206(5):1057-71.
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AID in somatic hypermutation and class switch recombination. Curr Opin Immunol. 2006 Apr; 18(2):164-74.
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Genetic changes occurring in established tumors rapidly stimulate new antibody responses. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5425-30.
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The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes. Mol Immunol. 1997 May; 34(7):527-33.
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Gamma 2b transgenic mice as a model for the role of immunoglobulins in B cell development. Immunol Res. 1994; 13(4):291-8.
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Heavy-chain class switch does not terminate somatic mutation. J Exp Med. 1990 Aug 01; 172(2):531-6.
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How immunoglobulin V kappa genes rearrange. J Immunol. 1987 Dec 01; 139(11):3834-9.