Peptide Initiation Factors
"Peptide Initiation Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein factors uniquely required during the initiation phase of protein synthesis in GENETIC TRANSLATION.
| Descriptor ID |
D010448
|
| MeSH Number(s) |
D12.776.835.725
|
| Concept/Terms |
Peptide Initiation Factors- Peptide Initiation Factors
- Factors, Peptide Initiation
- Initiation Factors, Peptide
- Initiation Factors
- Initiation Factor
|
Below are MeSH descriptors whose meaning is more general than "Peptide Initiation Factors".
Below are MeSH descriptors whose meaning is more specific than "Peptide Initiation Factors".
This graph shows the total number of publications written about "Peptide Initiation Factors" by people in this website by year, and whether "Peptide Initiation Factors" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2010 | 1 | 2 | 3 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2019 | 2 | 1 | 3 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Peptide Initiation Factors" by people in Profiles.
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Hypusinated and unhypusinated isoforms of the translation factor eIF5A exert distinct effects in models of pancreas development and function. J Biol Chem. 2025 Feb; 301(2):108209.
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Oxygen level regulates N-terminal translation elongation of selected proteins through deoxyhypusine hydroxylation. Cell Rep. 2022 05 24; 39(8):110855.
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Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes. PLoS One. 2020; 15(3):e0230627.
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Hypusine biosynthesis in ß cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis. Sci Signal. 2019 12 03; 12(610).
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eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 Diabetes. Sci Rep. 2019 02 07; 9(1):1533.
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Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder. Am J Hum Genet. 2019 02 07; 104(2):287-298.
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N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency. Cell. 2015 Jun 04; 161(6):1388-99.
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Eukaryotic translation initiation factor 5A inhibition alters physiopathology and immune responses in a "humanized" transgenic mouse model of type 1 diabetes. Am J Physiol Endocrinol Metab. 2014 Apr 01; 306(7):E791-8.
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Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy. Amino Acids. 2014 Mar; 46(3):633-42.
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Translational control of inducible nitric oxide synthase by p38 MAPK in islet ß-cells. Mol Endocrinol. 2013 Feb; 27(2):336-49.