"Insulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
| Descriptor ID |
D007328
|
| MeSH Number(s) |
D06.472.699.587.200.500.625 D12.644.548.586.200.500.625
|
| Concept/Terms |
Insulin- Insulin
- Insulin, Regular
- Regular Insulin
- Soluble Insulin
- Insulin, Soluble
|
Below are MeSH descriptors whose meaning is more general than "Insulin".
Below are MeSH descriptors whose meaning is more specific than "Insulin".
This graph shows the total number of publications written about "Insulin" by people in this website by year, and whether "Insulin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 17 | 11 | 28 |
| 1997 | 12 | 11 | 23 |
| 1998 | 13 | 4 | 17 |
| 1999 | 5 | 15 | 20 |
| 2000 | 18 | 11 | 29 |
| 2001 | 10 | 10 | 20 |
| 2002 | 12 | 10 | 22 |
| 2003 | 10 | 9 | 19 |
| 2004 | 12 | 12 | 24 |
| 2005 | 14 | 9 | 23 |
| 2006 | 15 | 8 | 23 |
| 2007 | 12 | 13 | 25 |
| 2008 | 11 | 18 | 29 |
| 2009 | 14 | 23 | 37 |
| 2010 | 15 | 14 | 29 |
| 2011 | 9 | 6 | 15 |
| 2012 | 10 | 9 | 19 |
| 2013 | 13 | 19 | 32 |
| 2014 | 16 | 18 | 34 |
| 2015 | 19 | 16 | 35 |
| 2016 | 10 | 11 | 21 |
| 2017 | 20 | 11 | 31 |
| 2018 | 15 | 22 | 37 |
| 2019 | 8 | 12 | 20 |
| 2020 | 7 | 10 | 17 |
| 2021 | 7 | 17 | 24 |
| 2022 | 0 | 13 | 13 |
| 2023 | 4 | 11 | 15 |
| 2024 | 7 | 4 | 11 |
| 2025 | 6 | 9 | 15 |
| 2026 | 1 | 5 | 6 |
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Below are the most recent publications written about "Insulin" by people in Profiles.
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Insulin resistance and type 2 diabetes as allostatic responses to chronic nutrient excess. Cell Metab. 2026 Aug 04; 38(8):1540-1556.
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Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity. Elife. 2026 Jun 08; 14.
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Nematode extracellular protein interactome expands connections between signaling pathways. Cell Genom. 2026 May 13; 6(5):101161.
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Endogenous GIP signaling is indispensable for DPP-4 inhibitor-mediated metabolic control in mice. J Diabetes Investig. 2026 Apr; 17(4):567-575.
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The Role of the Oral Microbiome in Circulating Metabolic Biomarkers and the Influence of Air Pollution. Oral Dis. 2026 Jun; 32(6):1665-1674.
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ChREBP deficiency aggravates diabetic sarcopenia by disrupting glucose signaling: a novel mouse model of muscle atrophy. J Endocrinol. 2026 Jan 01; 268(1).
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Preparing to Meet the Needs of a Growing Older Adult Population with Type 1 Diabetes: A Narrative Review. J Gen Intern Med. 2026 03; 41(4):1116-1128.
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Regulatory Roles of IGF2R in Insulin Secretion and Adaptive ß-Cell Proliferation. Diabetes. 2025 Dec 01; 74(12):2351-2364.
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Creatine kinase B regulates glycolysis and de novo lipogenesis pathways to control lipid accumulation during adipogenesis. Cell Rep. 2025 11 25; 44(11):116489.
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Genome-wide CRISPR Screen Identifies Sec31A as a Key Regulator of Alpha Cell Survival. Nat Commun. 2025 Oct 15; 16(1):9159.