 Phosphogluconate Dehydrogenase
"Phosphogluconate Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the oxidoreductase class that catalyzes the reaction 6-phospho-D-gluconate and NADP+ to yield D-ribulose 5-phosphate, carbon dioxide, and NADPH. The reaction is a step in the pentose phosphate pathway of glucose metabolism. (From Dorland, 27th ed) EC 1.1.1.43.
| Descriptor ID |
D010734
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| MeSH Number(s) |
D08.811.682.047.150.600
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| Concept/Terms |
Phosphogluconate Dehydrogenase- Phosphogluconate Dehydrogenase
- Dehydrogenase, Phosphogluconate
- 6-Phosphogluconate Dehydrogenase
- 6 Phosphogluconate Dehydrogenase
- Dehydrogenase, 6-Phosphogluconate
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Below are MeSH descriptors whose meaning is more general than "Phosphogluconate Dehydrogenase".
Below are MeSH descriptors whose meaning is more specific than "Phosphogluconate Dehydrogenase".
This graph shows the total number of publications written about "Phosphogluconate Dehydrogenase" by people in this website by year, and whether "Phosphogluconate Dehydrogenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Phosphogluconate Dehydrogenase" by people in Profiles.
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Elf S, Lin R, Xia S, Pan Y, Shan C, Wu S, Lonial S, Gaddh M, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Boggon TJ, Fan J, Chen J. Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin. Oncogene. 2017 01 12; 36(2):254-262.
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Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov; 17(11):1484-96.
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Shan C, Elf S, Ji Q, Kang HB, Zhou L, Hitosugi T, Jin L, Lin R, Zhang L, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Mol Cell. 2014 Aug 21; 55(4):552-65.
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Bitran J, Golomb HM, Rowley JD. Idiopathic acquired refractory sideroblastic anemia: Banded chromosome analysis in six patients. Acta Haematol. 1977; 57(1):15-23.
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