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Mostafa El Dafrawy

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentOrthopedic Surgery and Rehabilitation Medicine
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Orthopaedic surgeon Mostafa El Dafrawy, MBBCh, provides comprehensive spine care to patients with a wide range of spine conditions. Dr. El Dafrawy specializes in complex spinal deformities, spine trauma, degenerative disorders of the cervical and thoraco-lumbar spine, and spinal tumors.

    With his expertise in revision spine surgery and spinal reconstruction, Dr. El Dafrawy enhances the lives of his patients by restoring mobility and reducing back pain. He is thrilled to be able to offer spine deformity surgeries and revision surgeries for patients who had a failed back surgery or developed flat back syndrome.

    As a physician-scientist, Dr. El Dafrawy is also committed to using basic, clinical and transitional research to investigate novel therapies for spine patients to improve their overall quality of life. His research interests include: adult degenerative scoliosis, kyphoscoliosis and flat back deformities as well as spine tumors, particularly the treatment and management of metastatic spine disease. He has authored numerous research publications and book chapters, and his work has been published in highly respected, peer-reviewed journals, such as Spine, Journal of Bone and Joint Surgery, Spine Deformity, Journal of Neurosurgery Spine and Orthopedics.


    Collapse Biography 
    Collapse education and training
    Washington University in Saint Louis , Saint LouisSpine Surgery Fellowship08/2019Complex Adult and Pediatric Spine reconstruction
    The Johns Hopkins University Hospital, Baltimore, MDOrthopaedic Surgery Residency07/2018Orthopaedic Surgery
    The Johns Hopkins University Hospital, Baltimore, MDGeneral Surgery Internship07/2013General Surgery Internship
    Cairo University Hospital, Cairo, EgyptOrthopaedic Surgery Residency05/2010Orthopaedic Surgery
    The Johns Hopkins University , Baltimore, MDResearch Fellowship07/2012Spine Surgery Research Fellowship

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Dahm J, Nwaudo D, Gooi Z, Lee M, El Dafrawy M. Migration of an Anterior Cervical Discectomy and Fusion Screw into the Constrictor Muscle of the Hypopharynx: A Case Report. JBJS Case Connect. 2021 05 19; 11(2). PMID: 34010178.
      View in: PubMed
    2. Pirkle S, Bhattacharjee S, El Dafrawy M, Leucht P, Shi LL, Lee MJ. The Influence of Selective Serotonin Reuptake Inhibitors on Lumbar Arthrodesis. Clin Spine Surg. 2021 05 01; 34(4):E200-E204. PMID: 32991364.
      View in: PubMed
    3. Zhao X, Hu DA, Wu D, He F, Wang H, Huang L, Shi D, Liu Q, Ni N, Pakvasa M, Zhang Y, Fu K, Qin KH, Li AJ, Hagag O, Wang EJ, Sabharwal M, Wagstaff W, Reid RR, Lee MJ, Wolf JM, El Dafrawy M, Hynes K, Strelzow J, Ho SH, He TC, Athiviraham A. Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering. Front Bioeng Biotechnol. 2021; 9:603444. PMID: 33842441.
      View in: PubMed
    4. Luo W, Zhang L, Huang B, Zhang H, Zhang Y, Zhang F, Liang P, Chen Q, Cheng Q, Tan D, Tan Y, Song J, Zhao T, Haydon RC, Reid RR, Luu HH, Lee MJ, El Dafrawy M, Ji P, He TC, Gou L. BMP9-initiated osteogenic/odontogenic differentiation of mouse tooth germ mesenchymal cells (TGMCS) requires Wnt/ß-catenin signalling activity. J Cell Mol Med. 2021 03; 25(5):2666-2678. PMID: 33605035.
      View in: PubMed
    5. Seidel H, Bhattacharjee S, Pirkle S, Shi L, Strelzow J, Lee M, El Dafrawy M. Long-term rates of bladder dysfunction after decompression in patients with cauda equina syndrome. Spine J. 2021 05; 21(5):803-809. PMID: 33434651.
      View in: PubMed
    6. Zhang Y, Wu D, Zhao X, Pakvasa M, Tucker AB, Luo H, Qin KH, Hu DA, Wang EJ, Li AJ, Zhang M, Mao Y, Sabharwal M, He F, Niu C, Wang H, Huang L, Shi D, Liu Q, Ni N, Fu K, Chen C, Wagstaff W, Reid RR, Athiviraham A, Ho S, Lee MJ, Hynes K, Strelzow J, He TC, El Dafrawy M. Stem Cell-Friendly Scaffold Biomaterials: Applications for Bone Tissue Engineering and Regenerative Medicine. Front Bioeng Biotechnol. 2020; 8:598607. PMID: 33381499.
      View in: PubMed
    7. Huang X, Chen Q, Luo W, Pakvasa M, Zhang Y, Zheng L, Li S, Yang Z, Zeng H, Liang F, Zhang F, Hu DA, Qin KH, Wang EJ, Qin DS, Reid RR, He TC, Athiviraham A, El Dafrawy M, Zhang H. SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine. Genes Dis. 2022 Jan; 9(1):95-107. PMID: 35005110.
      View in: PubMed
    8. He F, Ni N, Zeng Z, Wu D, Feng Y, Li AJ, Luu B, Li AF, Qin K, Wang E, Wang X, Wu X, Luo H, Zhang J, Zhang M, Mao Y, Pakvasa M, Wagstaff W, Zhang Y, Niu C, Wang H, Huang L, Shi D, Liu Q, Zhao X, Fu K, Reid RR, Wolf JM, Lee MJ, Hynes K, Strelzow J, El Dafrawy M, Gan H, He TC, Fan J. FAMSi: A Synthetic Biology Approach to the Fast Assembly of Multiplex siRNAs for Silencing Gene Expression in Mammalian Cells. Mol Ther Nucleic Acids. 2020 Dec 04; 22:885-899. PMID: 33230483.
      View in: PubMed
    9. El Dafrawy MH, Adogwa O, Wegner AM, Pallotta NA, Kelly MP, Kebaish KM, Bridwell KH, Gupta MC. Comprehensive classification system for multirod constructs across three-column osteotomies: a reliability study. J Neurosurg Spine. 2020 Oct 09; 1-7. PMID: 33036005.
      View in: PubMed
    10. El Dafrawy M, Bridwell K, Adogwa O, Shlykov M, Koscso J, Lenke LG, Lertudomphonwanit T, Kelly MP, Gupta M. Rod fractures and nonunions after long fusion to the sacrum for primary presentation adult spinal deformity: a comparison with and without interbody fusion in the distal lumbar spine. Spine Deform. 2021 01; 9(1):231-237. PMID: 32725494.
      View in: PubMed
    11. Raad M, Harris AB, Puvanesarajah V, El Dafrawy MH, Kebaish FN, Neuman BJ, Skolasky RL, Cohen DB, Kebaish KM. Preoperative patient expectations and pain improvement after adult spinal deformity surgery. J Neurosurg Spine. 2020 Jun 12; 1-6. PMID: 32534485.
      View in: PubMed
    12. Wang X, Zhao L, Wu X, Luo H, Wu D, Zhang M, Zhang J, Pakvasa M, Wagstaff W, He F, Mao Y, Zhang Y, Niu C, Wu M, Zhao X, Wang H, Huang L, Shi D, Liu Q, Ni N, Fu K, Hynes K, Strelzow J, El Dafrawy M, He TC, Qi H, Zeng Z. Development of a simplified and inexpensive RNA depletion method for plasmid DNA purification using size selection magnetic beads (SSMBs). Genes Dis. 2021 May; 8(3):298-306. PMID: 33997177.
      View in: PubMed
    13. Pakvasa M, Haravu P, Boachie-Mensah M, Jones A, Coalson E, Liao J, Zeng Z, Wu D, Qin K, Wu X, Luo H, Zhang J, Zhang M, He F, Mao Y, Zhang Y, Niu C, Wu M, Zhao X, Wang H, Huang L, Shi D, Liu Q, Ni N, Fu K, Lee MJ, Wolf JM, Athiviraham A, Ho SS, He TC, Hynes K, Strelzow J, El Dafrawy M, Reid RR. Notch signaling: Its essential roles in bone and craniofacial development. Genes Dis. 2021 Jan; 8(1):8-24. PMID: 33569510.
      View in: PubMed
    14. Zhang B, Yang L, Zeng Z, Feng Y, Wang X, Wu X, Luo H, Zhang J, Zhang M, Pakvasa M, Wagstaff W, He F, Mao Y, Qin K, Ding H, Zhang Y, Niu C, Wu M, Zhao X, Wang H, Huang L, Shi D, Liu Q, Ni N, Fu K, Athiviraham A, Moriatis Wolf J, Lee MJ, Hynes K, Strelzow J, El Dafrawy M, Xia Y, He TC. Leptin Potentiates BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Through the Activation of JAK/STAT Signaling. Stem Cells Dev. 2020 04 15; 29(8):498-510. PMID: 32041483.
      View in: PubMed
    15. Klyce W, Nhan DT, Dunham AM, El Dafrawy MH, Shannon C, LaPorte DM. The Times, They Are A-Changing: Women Entering Academic Orthopedics Today Are Choosing Nonpediatric Fellowships at a Growing Rate. J Surg Educ. 2020 May - Jun; 77(3):564-571. PMID: 31932218.
      View in: PubMed
    16. El Dafrawy MH, Raad M, Okafor L, Kebaish KM. Sacropelvic Fixation: A Comprehensive Review. Spine Deform. 2019 Jul; 7(4):509-516. PMID: 31981134.
      View in: PubMed
    17. Mitchell SL, Donaldson CJ, El Dafrawy MH, Kebaish KM. Difficulties in Treating Postirradiation Kyphosis in Adults: A Series of Five Cases. Spine Deform. 2019 Nov; 7(6):937-944. PMID: 31974987.
      View in: PubMed
    18. El Dafrawy MH, Shafiq B, Vaswani R, Osgood GM, Hasenboehler EA, Kebaish KM. Minimally Invasive Fixation for Spinopelvic Dissociation: Percutaneous Triangular Osteosynthesis with S2 Alar-Iliac and Iliosacral Screws: A Case Report. JBJS Case Connect. 2019 Dec; 9(4):e0119. PMID: 31833978.
      View in: PubMed
    19. Mitchell SL, Donaldson CJ, El Dafrawy MH, Kebaish KM. Difficulties in Treating Postirradiation Kyphosis in Adults: A Series of Five Cases. Spine Deform. 2019 11; 7(6):937-944. PMID: 31732005.
      View in: PubMed
    20. Adogwa O, Buchowski JM, Lenke LG, Shlykov MA, El Dafrawy M, Lertudomphonwanit T, Obey MR, Koscso J, Gupta MC, Bridwell KH. Comparison of rod fracture rates in long spinal deformity constructs after transforaminal versus anterior lumbar interbody fusions: a single-institution analysis. J Neurosurg Spine. 2019 Oct 11; 1-8. PMID: 31604326.
      View in: PubMed
    21. Raad M, Puvanesarajah V, Harris A, El Dafrawy MH, Khashan M, Jain A, Hassanzadeh H, Kebaish KM. The learning curve for performing three-column osteotomies in adult spinal deformity patients: one surgeon's experience with 197 cases. Spine J. 2019 12; 19(12):1926-1933. PMID: 31310816.
      View in: PubMed
    22. El Dafrawy MH, Raad M, Okafor L, Kebaish KM. Sacropelvic Fixation: A Comprehensive Review. Spine Deform. 2019 07; 7(4):509-516. PMID: 31202365.
      View in: PubMed
    23. Feder OI, El Dafrawy MH, Morris CD. Pelvis allograft with constrained total hip arthroplasty for shoulder reconstruction. J Shoulder Elbow Surg. 2019 03; 28(3):e92-e96. PMID: 30771828.
      View in: PubMed
    24. Khashan M, Raad M, El Dafrawy MH, Puvanesarajah V, Kebaish KM. Postoperative changes in neurological function after 3-column osteotomy: risk factor analysis of 199 patients. J Neurosurg Spine. 2019 Feb 08; 1-6. PMID: 30738395.
      View in: PubMed
    25. Raad M, Reidler JS, El Dafrawy MH, Amin RM, Jain A, Neuman BJ, Riley LH, Sciubba DM, Kebaish KM, Skolasky RL. US regional variations in rates, outcomes, and costs of spinal arthrodesis for lumbar spinal stenosis in working adults aged 40-65 years. J Neurosurg Spine. 2018 11 02; 30(1):83-90. PMID: 30485187.
      View in: PubMed
    26. Raad M, Donaldson CJ, El Dafrawy MH, Sciubba DM, Riley LH, Neuman BJ, Kebaish KM, Skolasky RL. Trends in isolated lumbar spinal stenosis surgery among working US adults aged 40-64 years, 2010-2014. J Neurosurg Spine. 2018 08; 29(2):169-175. PMID: 29799337.
      View in: PubMed
    27. El Dafrawy MH, Strike SA, Osgood GM. Use of the S3 Corridor for Iliosacral Fixation in a Dysmorphic Sacrum: A Case Report. JBJS Case Connect. 2017 Jul-Sep; 7(3):e62. PMID: 29252891.
      View in: PubMed
    28. Ponnusamy KE, Naseer Z, El Dafrawy MH, Okafor L, Alexander C, Sterling RS, Khanuja HS, Skolasky RL. Post-Discharge Care Duration, Charges, and Outcomes Among Medicare Patients After Primary Total Hip and Knee Arthroplasty. J Bone Joint Surg Am. 2017 Jun 07; 99(11):e55. PMID: 28590385.
      View in: PubMed
    29. Lopez J, Ahmed R, Bae S, Hicks CW, El Dafrawy M, Osgood GM, Segev DL. A New Culture of Transparency: Industry Payments to Orthopedic Surgeons. Orthopedics. 2016 Nov 01; 39(6):e1058-e1062. PMID: 27459138.
      View in: PubMed
    30. Mesfin A, El Dafrawy MH, Jain A, Hassanzadeh H, Kebaish KM. Total En Bloc Spondylectomy for Primary and Metastatic Spine Tumors. Orthopedics. 2015 Nov; 38(11):e995-e1000. PMID: 26558680.
      View in: PubMed
    31. El Dafrawy MH, Osgood GM. Retrieval of broken iliosacral screws: the power of a push screw. Injury. 2015 Jul; 46(7):1411-6. PMID: 25986663.
      View in: PubMed
    32. Mesfin A, El Dafrawy MH, Jain A, Hassanzadeh H, Kostuik JP, Lemma MA, Kebaish KM. Surgical outcomes of long spinal fusions for scoliosis in adult patients with rheumatoid arthritis. J Neurosurg Spine. 2015 Apr; 22(4):367-73. PMID: 25658465.
      View in: PubMed
    33. El Dafrawy MH, Kebaish KM. Percutaneous S2 alar iliac fixation for pelvic insufficiency fracture. Orthopedics. 2014 Nov; 37(11):e1033-5. PMID: 25361366.
      View in: PubMed
    34. El Dafrawy M, Baras A, Ahuja N. Firm flank mass decreasing in size after pregnancy. JAMA Surg. 2014 Oct; 149(10):1089-90. PMID: 25162611.
      View in: PubMed
    35. Hassanzadeh H, Jain A, El Dafrawy MH, Ain MC, Skolasky RL, Kebaish KM. Clinical Results and Functional Outcomes in Adult Patients After Revision Surgery for Spinal Deformity Correction: Patients Younger than 65 Years Versus 65 Years and Older. Spine Deform. 2013 Sep; 1(5):371-376. PMID: 27927395.
      View in: PubMed
    36. Hassanzadeh H, Jain A, El Dafrawy MH, Mesfin A, Neubauer PR, Skolasky RL, Kebaish KM. Clinical results and functional outcomes of primary and revision spinal deformity surgery in adults. J Bone Joint Surg Am. 2013 Aug 07; 95(15):1413-9. PMID: 23925747.
      View in: PubMed
    37. Hassanzadeh H, Gupta S, Jain A, El Dafrawy MH, Skolasky RL, Kebaish KM. Type of Anchor at the Proximal Fusion Level Has a Significant Effect on the Incidence of Proximal Junctional Kyphosis and Outcome in Adults After Long Posterior Spinal Fusion. Spine Deform. 2013 Jul; 1(4):299-305. PMID: 27927362.
      View in: PubMed
    38. Hassanzadeh H, Jain A, El Dafrawy MH, Ain MC, Mesfin A, Skolasky RL, Kebaish KM. Three-column osteotomies in the treatment of spinal deformity in adult patients 60 years old and older: outcome and complications. Spine (Phila Pa 1976). 2013 Apr 20; 38(9):726-31. PMID: 23138408.
      View in: PubMed
    39. Hassanzadeh H, Gjolaj JP, El Dafrawy MH, Jain A, Skolasky RL, Cohen DB, Kebaish KM. The timing of surgical staging has a significant impact on the complications and functional outcomes of adult spinal deformity surgery. Spine J. 2013 Dec; 13(12):1717-22. PMID: 23602375.
      View in: PubMed
    40. Malloy JP, Dalling JG, El Dafrawy MH, Bustillo JS, Reid JS. Tibiofibular bone-bridging osteoplasty in transtibial amputation: case report and description of technique. J Surg Orthop Adv. 2012; 21(4):270-4. PMID: 23327855.
      View in: PubMed
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