Pregnenolone Carbonitrile
"Pregnenolone Carbonitrile" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A catatoxic steroid and microsomal enzyme inducer having significant effects on the induction of cytochrome P450. It has also demonstrated the potential for protective capability against acetaminophen-induced liver damage.
| Descriptor ID |
D011285
|
| MeSH Number(s) |
D02.626.745 D04.210.500.745.745.725.703
|
| Concept/Terms |
Pregnenolone Carbonitrile- Pregnenolone Carbonitrile
- Carbonitrile, Pregnenolone
- Pregnenolone 16 alpha-Carbonitrile
- 16 alpha-Carbonitrile, Pregnenolone
- Pregnenolone 16 alpha Carbonitrile
- PCN
|
Below are MeSH descriptors whose meaning is more general than "Pregnenolone Carbonitrile".
Below are MeSH descriptors whose meaning is more specific than "Pregnenolone Carbonitrile".
This graph shows the total number of publications written about "Pregnenolone Carbonitrile" by people in this website by year, and whether "Pregnenolone Carbonitrile" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2005 | 2 | 0 | 2 |
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Below are the most recent publications written about "Pregnenolone Carbonitrile" by people in Profiles.
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Microarray analysis on Phase II drug metabolizing enzymes expression in pregnant rats after treatment with pregnenolone-16alpha-carbonitrile or phenobarbital. Exp Mol Pathol. 2005 Dec; 79(3):272-7.
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Microarray analysis on CYPs expression in pregnant rats after treatment with pregnenolone-16alpha-carbonitrile and phenobarbital. Exp Mol Pathol. 2005 Feb; 78(1):71-7.
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Induction of CYP3A1 by dexamethasone and pregnenolone-16alpha-carbonitrile in pregnant rat and fetal livers and placenta. Exp Toxicol Pathol. 2003 Mar; 54(4):273-9.