"Tyrphostins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of synthetic protein tyrosine kinase inhibitors. They selectively inhibit receptor autophosphorylation and are used to study receptor function.
| Descriptor ID |
D020032
|
| MeSH Number(s) |
D02.455.426.559.389.150.795 D02.626.886 D03.633.100.857.885
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Tyrphostins".
Below are MeSH descriptors whose meaning is more specific than "Tyrphostins".
This graph shows the total number of publications written about "Tyrphostins" by people in this website by year, and whether "Tyrphostins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tyrphostins" by people in Profiles.
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Sphingosine-1-Phosphate Induces the Migration and Angiogenesis of Epcs Through the Akt Signaling Pathway via Sphingosine-1-Phosphate Receptor 3/Platelet-Derived Growth Factor Receptor-ß. Cell Mol Biol Lett. 2015 Dec; 20(4):597-611.
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c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury. Am J Physiol Lung Cell Mol Physiol. 2015 May 15; 308(10):L1025-38.
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Inhibition of both EGFR and IGF1R sensitized prostate cancer cells to radiation by synergistic suppression of DNA homologous recombination repair. PLoS One. 2013; 8(8):e68784.
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Activation of host tissue trophic factors through JAK-STAT3 signaling: a mechanism of mesenchymal stem cell-mediated cardiac repair. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1428-38.
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Stretching the search for therapeutic targets in acute lung injury. Transl Res. 2008 Dec; 152(6):255-6.
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EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation. Am J Respir Cell Mol Biol. 2007 Mar; 36(3):304-12.
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AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis. J Cell Biol. 2006 Jan 30; 172(3):409-21.
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Analysis of signal transducer and activator of transcription 3 (STAT3) in gastrointestinal stromal tumors. Anticancer Res. 2003 May-Jun; 23(3B):2253-60.
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Tyrosine kinase inhibition affects type 1 angiotensin II receptor internalization. J Recept Signal Transduct Res. 1999 Nov; 19(6):975-93.
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Tyrosine kinase inhibitors modulate the ventilatory response to hypoxia in the conscious rat. J Appl Physiol (1985). 1999 Jul; 87(1):363-9.