 Physostigmine
"Physostigmine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.
| Descriptor ID |
D010830
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| MeSH Number(s) |
D02.241.081.251.583.682 D03.132.436.545 D03.438.473.402.545
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Physostigmine".
Below are MeSH descriptors whose meaning is more specific than "Physostigmine".
This graph shows the total number of publications written about "Physostigmine" by people in this website by year, and whether "Physostigmine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1984 | 1 | 0 | 1 | | 1987 | 0 | 1 | 1 | | 1989 | 2 | 0 | 2 | | 1990 | 0 | 2 | 2 | | 1991 | 0 | 2 | 2 | | 1992 | 0 | 1 | 1 | | 1993 | 1 | 0 | 1 | | 1994 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 |
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Below are the most recent publications written about "Physostigmine" by people in Profiles.
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Monte O, Zyngier S, Kimura ET, Bianco AC. [Dopaminergic and somatostatinergic pathways decrease serum thyrotropin in rats bearing the 256-Walker mammary carcinoma]. Arq Bras Endocrinol Metabol. 2005 Apr; 49(2):253-64.
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Mitchell RW, Ndukwu IM, Leff AR, Padrid PA. Muscarinic hyperresponsiveness of antigen-sensitized feline airway smooth muscle in vitro. Am J Vet Res. 1997 Jun; 58(6):672-6.
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Friedman A, Kaufer D, Shemer J, Hendler I, Soreq H, Tur-Kaspa I. Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response. Nat Med. 1996 Dec; 2(12):1382-5.
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Bierer LM, Aisen PS, Davidson M, Ryan TM, Schmeidler J, Davis KL. A pilot study of clonidine plus physostigmine in Alzheimer's disease. Dementia. 1994 Sep-Oct; 5(5):243-6.
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Bierer LM, Aisen PS, Davidson M, Ryan TM, Stern RG, Schmeidler J, Davis KL. A pilot study of oral physostigmine plus yohimbine in patients with Alzheimer disease. Alzheimer Dis Assoc Disord. 1993; 7(2):98-104.
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Mitchell RW, Murphy TM, Leff AR. Physiological mechanisms mediating enhanced force generation during development and immune sensitization. Can J Physiol Pharmacol. 1992 Apr; 70(4):615-23.
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Murphy TM, Mitchell RW, Phillips IJ, Leff AR. Ontogenic expression of acetylcholinesterase activity in trachealis of young swine. Am J Physiol. 1991 Oct; 261(4 Pt 1):L322-6.
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Laganière S, Corey J, Tang XC, Wülfert E, Hanin I. Acute and chronic studies with the anticholinesterase Huperzine A: effect on central nervous system cholinergic parameters. Neuropharmacology. 1991 Jul; 30(7):763-8.
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Mitchell RW, Kelly E, Leff AR. Reduced activity of acetylcholinesterase in canine tracheal smooth muscle homogenates after active immune-sensitization. Am J Respir Cell Mol Biol. 1991 Jul; 5(1):56-62.
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Mitchell RW, Murphy TM, Kelly E, Leff AR. Maturation of acetylcholinesterase expression in tracheal smooth muscle contraction. Am J Physiol. 1990 Aug; 259(2 Pt 1):L130-5.
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