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Andrew Dahl

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Genetic Medicine
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    Our group focuses on computational approaches to discover and characterize context-specific genetic effects on complex disorders. This includes polygenic methods for gene-environment interaction, gene-gene interaction, and genetic subtypes of disease. We are particularly interested in applications to asthma, major depressive disorder, single cell omics, and cross-population portability of genetic predictions. Our long-term goal is to advance equitable precision treatment by embracing the full diversity of human contexts.


    Collapse Biography 
    Collapse education and training
    OxfordPhD10/2016Gen Med and Stats
    UChicagoMS06/2012Stats
    UChicagoHon BS06/2012Math
    UChicagoBA06/2012Econ
    Collapse awards and honors
    2012 - 2016Clarendon Scholarship, Oxford
    2012Phi Beta Kappa, UChicago

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Border R, Athanasiadis G, Buil A, Schork AJ, Cai N, Young AI, Werge T, Flint J, Kendler KS, Sankararaman S, Dahl AW, Zaitlen NA. Cross-trait assortative mating is widespread and inflates genetic correlation estimates. Science. 2022 11 18; 378(6621):754-761. PMID: 36395242.
      View in: PubMed
    2. Sheppard B, Rappoport N, Loh PR, Sanders SJ, Zaitlen N, Dahl A. A model and test for coordinated polygenic epistasis in complex traits. Proc Natl Acad Sci U S A. 2021 04 13; 118(15). PMID: 33833052.
      View in: PubMed
    3. Dahl A, Zaitlen N. Genetic Influences on Disease Subtypes. Annu Rev Genomics Hum Genet. 2020 08 31; 21:413-435. PMID: 32873077.
      View in: PubMed
    4. Steinsaltz D, Dahl A, Wachter KW. On Negative Heritability and Negative Estimates of Heritability. Genetics. 2020 06; 215(2):343-357. PMID: 32291292.
      View in: PubMed
    5. Dahl A, Nguyen K, Cai N, Gandal MJ, Flint J, Zaitlen N. A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits. Am J Hum Genet. 2020 01 02; 106(1):71-91. PMID: 31901249.
      View in: PubMed
    6. Hernandez RD, Uricchio LH, Hartman K, Ye C, Dahl A, Zaitlen N. Ultrarare variants drive substantial cis heritability of human gene expression. Nat Genet. 2019 09; 51(9):1349-1355. PMID: 31477931.
      View in: PubMed
    7. Dahl A, Cai N, Ko A, Laakso M, Pajukanta P, Flint J, Zaitlen N. Reverse GWAS: Using genetics to identify and model phenotypic subtypes. PLoS Genet. 2019 04; 15(4):e1008009. PMID: 30951530.
      View in: PubMed
    8. Dahl A, Guillemot V, Mefford J, Aschard H, Zaitlen N. Adjusting for Principal Components of Molecular Phenotypes Induces Replicating False Positives. Genetics. 2019 04; 211(4):1179-1189. PMID: 30692194.
      View in: PubMed
    9. Steinsaltz D, Dahl A, Wachter KW. Statistical properties of simple random-effects models for genetic heritability. Electron J Stat. 2018; 12(1):321-356. PMID: 30057658.
      View in: PubMed
    10. Dahl A, Iotchkova V, Baud A, Johansson Å, Gyllensten U, Soranzo N, Mott R, Kranis A, Marchini J. A multiple-phenotype imputation method for genetic studies. Nat Genet. 2016 Apr; 48(4):466-72. PMID: 26901065.
      View in: PubMed
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