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Andrew Dahl

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Genetic Medicine
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Our group focuses on computational approaches to discover and characterize context-specific genetic effects on complex disorders. This includes polygenic methods for gene-environment interaction, gene-gene interaction, and genetic subtypes of disease. We are particularly interested in applications to asthma, major depressive disorder, single cell omics, and cross-population portability of genetic predictions. Our long-term goal is to advance equitable precision treatment by embracing the full diversity of human contexts.

    Collapse Biography 
    Collapse education and training
    OxfordPhD10/2016Gen Med and Stats
    UChicagoHon BS06/2012Math
    Collapse awards and honors
    2012 - 2016Clarendon Scholarship, Oxford
    2012Phi Beta Kappa, UChicago

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. LaBianca S, Brikell I, Helenius D, Loughnan R, Mefford J, Palmer CE, Walker R, Gådin JR, Krebs M, Appadurai V, Vaez M, Agerbo E, Pedersen MG, Børglum AD, Hougaard DM, Mors O, Nordentoft M, Mortensen PB, Kendler KS, Jernigan TL, Geschwind DH, Ingason A, Dahl AW, Zaitlen N, Dalsgaard S, Werge TM, Schork AJ. Polygenic profiles define aspects of clinical heterogeneity in attention deficit hyperactivity disorder. Nat Genet. 2024 Feb; 56(2):234-244. PMID: 38036780.
      Citations: 1     Fields:    Translation:Humans
    2. Dahl A, Thompson M, An U, Krebs M, Appadurai V, Border R, Bacanu SA, Werge T, Flint J, Schork AJ, Sankararaman S, Kendler KS, Cai N. Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder. Nat Genet. 2023 Dec; 55(12):2082-2093. PMID: 37985818; PMCID: PMC10703686.
      Citations: 5     Fields:    Translation:Humans
    3. Lea AJ, Clark AG, Dahl AW, Devinsky O, Garcia AR, Golden CD, Kamau J, Kraft TS, Lim YAL, Martins DJ, Mogoi D, Pajukanta P, Perry GH, Pontzer H, Trumble BC, Urlacher SS, Venkataraman VV, Wallace IJ, Gurven M, Lieberman DE, Ayroles JF. Applying an evolutionary mismatch framework to understand disease susceptibility. PLoS Biol. 2023 09; 21(9):e3002311. PMID: 37695771; PMCID: PMC10513379.
      Citations: 2     Fields:    Translation:Humans
    4. Lea AJ, Clark AG, Dahl AW, Devinsky O, Garcia AR, Golden CD, Kamau J, Kraft TS, Lim YAL, Martins D, Mogoi D, Pajukanta P, Perry G, Pontzer H, Trumble BC, Urlacher SS, Venkataraman VV, Wallace IJ, Gurven M, Lieberman D, Ayroles JF. Evolutionary mismatch and the role of GxE interactions in human disease. ArXiv. 2023 Feb 13. PMID: 36713247; PMCID: PMC9882586.
    5. Border R, Athanasiadis G, Buil A, Schork AJ, Young AI, Werge T, Flint J, Kendler KS, Sankararaman S, Dahl AW, Zaitlen NA, Cai N. Cross-trait assortative mating is widespread and inflates genetic correlation estimates. Science. 2022 11 18; 378(6621):754-761. PMID: 36395242; PMCID: PMC9901291.
      Citations: 38     Fields:    Translation:Humans
    6. Sheppard B, Rappoport N, Loh PR, Sanders SJ, Zaitlen N, Dahl A. A model and test for coordinated polygenic epistasis in complex traits. Proc Natl Acad Sci U S A. 2021 04 13; 118(15). PMID: 33833052; PMCID: PMC8053945.
      Citations: 5     Fields:    Translation:Humans
    7. Dahl A, Zaitlen N. Genetic Influences on Disease Subtypes. Annu Rev Genomics Hum Genet. 2020 08 31; 21:413-435. PMID: 32873077.
      Citations: 9     Fields:    Translation:Humans
    8. Steinsaltz D, Dahl A, Wachter KW. On Negative Heritability and Negative Estimates of Heritability. Genetics. 2020 06; 215(2):343-357. PMID: 32291292; PMCID: PMC7268991.
      Citations: 17     Fields:    Translation:Humans
    9. Dahl A, Nguyen K, Cai N, Gandal MJ, Flint J, Zaitlen N. A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits. Am J Hum Genet. 2020 01 02; 106(1):71-91. PMID: 31901249; PMCID: PMC7042488.
      Citations: 25     Fields:    Translation:HumansAnimals
    10. Hernandez RD, Uricchio LH, Hartman K, Ye C, Dahl A, Zaitlen N. Ultrarare variants drive substantial cis heritability of human gene expression. Nat Genet. 2019 09; 51(9):1349-1355. PMID: 31477931; PMCID: PMC6730564.
      Citations: 55     Fields:    Translation:HumansCells
    11. Dahl A, Cai N, Ko A, Laakso M, Flint J, Zaitlen N, Pajukanta P. Reverse GWAS: Using genetics to identify and model phenotypic subtypes. PLoS Genet. 2019 04; 15(4):e1008009. PMID: 30951530; PMCID: PMC6469799.
      Citations: 21     Fields:    Translation:Humans
    12. Dahl A, Mefford J, Zaitlen N, Guillemot V, Aschard H. Adjusting for Principal Components of Molecular Phenotypes Induces Replicating False Positives. Genetics. 2019 04; 211(4):1179-1189. PMID: 30692194; PMCID: PMC6456307.
      Citations: 8     Fields:    Translation:HumansAnimals
    13. Steinsaltz D, Dahl A, Wachter KW. Statistical properties of simple random-effects models for genetic heritability. Electron J Stat. 2018; 12(1):321-356. PMID: 30057658; PMCID: PMC6063091.
      Citations: 5     
    14. Dahl A, Iotchkova V, Baud A, Gyllensten U, Soranzo N, Mott R, Kranis A, Marchini J, Johansson Å. A multiple-phenotype imputation method for genetic studies. Nat Genet. 2016 Apr; 48(4):466-72. PMID: 26901065; PMCID: PMC4817234.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
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