"Histone Deacetylases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.
| Descriptor ID |
D006655
|
| MeSH Number(s) |
D08.811.277.087.520
|
| Concept/Terms |
Histone Deacetylases- Histone Deacetylases
- Deacetylases, Histone
- Histone Deacetylase
- Deacetylase, Histone
- HDAC Proteins
|
Below are MeSH descriptors whose meaning is more general than "Histone Deacetylases".
Below are MeSH descriptors whose meaning is more specific than "Histone Deacetylases".
This graph shows the total number of publications written about "Histone Deacetylases" by people in this website by year, and whether "Histone Deacetylases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 0 | 1 |
| 2005 | 2 | 2 | 4 |
| 2006 | 0 | 2 | 2 |
| 2007 | 2 | 1 | 3 |
| 2008 | 2 | 2 | 4 |
| 2009 | 1 | 0 | 1 |
| 2010 | 2 | 5 | 7 |
| 2011 | 0 | 5 | 5 |
| 2012 | 1 | 4 | 5 |
| 2013 | 2 | 1 | 3 |
| 2014 | 1 | 1 | 2 |
| 2015 | 2 | 1 | 3 |
| 2016 | 1 | 0 | 1 |
| 2017 | 3 | 0 | 3 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 2 | 1 | 3 |
| 2021 | 1 | 1 | 2 |
| 2022 | 1 | 1 | 2 |
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Below are the most recent publications written about "Histone Deacetylases" by people in Profiles.
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Targeting Class I Histone Deacetylases in Human Uterine Leiomyosarcoma. Cells. 2022 Nov 27; 11(23).
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Protein phosphatase 1 regulates reactive oxygen species-dependent degradation of histone deacetylase 5 by intermittent hypoxia. Am J Physiol Cell Physiol. 2022 08 01; 323(2):C423-C431.
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Discovery of 2,4-pyrimidinediamine derivatives as potent dual inhibitors of ALK and HDAC. Eur J Med Chem. 2021 Nov 15; 224:113672.
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Nuclear Sphingosine-1-phosphate Lyase Generated ?2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells. Cell Biochem Biophys. 2021 Sep; 79(3):575-592.
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HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity. Genes Dev. 2020 07 01; 34(13-14):973-988.
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Role of class I histone deacetylases in the regulation of maspin expression in prostate cancer. Mol Carcinog. 2020 08; 59(8):955-966.
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S1P and plasmalogen derived fatty aldehydes in cellular signaling and functions. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 07; 1865(7):158681.
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GADD45? Activated Early in the Course of Herpes Simplex Virus 1 Infection Suppresses the Activation of a Network of Innate Immunity Genes. J Virol. 2019 04 01; 93(7).
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HDAC3-Selective Inhibition Activates Brown and Beige Fat Through PRDM16. Endocrinology. 2018 07 01; 159(7):2520-2527.
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Nuclear lipid mediators: Role of nuclear sphingolipids and sphingosine-1-phosphate signaling in epigenetic regulation of inflammation and gene expression. J Cell Biochem. 2018 08; 119(8):6337-6353.