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Bernard Roizman

TitleEmeritus/Emerita, Professor
InstitutionUniversity of Chicago
DepartmentBSD Microbiology
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    Herpes simplex viruses cause two kinds of infections. On initial infection at the portal of entry into the body, the virus replicates and kills the infected cell (lytic infection). In the course of its replication, the virus infects nerve endings and is transported retrograde to neuronal nuclei of peripheral ganglia where it remains latent (silent) and does not harm the neuron. In some individuals the virus periodically reactivates, and is transported anterograde to a site near the portal of entry where it can cause recurrent lesions.

    The focus of the research conducted in this laboratory is on the mechanism by which herpes simplex virus with less than 100 genes takes over a human cell with more than 20,000 genes in both lytic and latent infection.

    Collapse Biography 
    Collapse education and training
    Johns Hopkins University, MDScD1956
    Collapse awards and honors
    2017Selman A. Waksman Award in Microbiology, National Academy of Sciences
    2015Establishment of the Roizman Institute for Biomedical Research, Shenzhen, China
    2013Fellow, National Academy of Inventors
    2008Lifetime Achievement Award, ASM-Abbot
    2004Fellow, American Association for the Advancement of Science
    2003Quantrell Award for Excellence in Undergraduate Teaching, University of Chicago
    2001Member, National Academy of Medicine (IOM)
    2001Honorary Doctorate in Medicine, University of Valladolid, Spain
    2000Foreign Member, Chinese Academy of Engineering (Medicine)
    1998Ryerson Lecture, University of Chicago
    1997J. Allyn Taylor International Prize in Medicine, Robarts Research Institute
    1997Honorary Doctorate in Science, University of Paris, France
    1995Honorary Member, Hungarian Academy of Sciences
    1992Fellow, American Academy of Microbiology
    1991Fellow, American Academy of Arts and Sciences
    1991Honorary Doctorate in Medicine and Surgery, University of Ferrara, Italy
    1984Honorary Doctorate in Humane Letters, Governors State University
    1979Member, National Academy of Sciences

    Collapse Research 
    Collapse research activities and funding
    R01CA115662     (ROIZMAN, BERNARD)Jun 10, 2005 - Apr 30, 2015
    NIH
    Selective Degradation of mRNA by Herpes Simplex Virus 1
    Role: Principal Investigator
    R13AI048841     (ROIZMAN, BERNARD)Mar 1, 2001 - Feb 28, 2002
    NIH
    CONFERENCE ON CONTROL OF VIRAL LATENCY AND PERSISTENCE
    Role: Principal Investigator
    R01CA088860     (ROIZMAN, BERNARD)Dec 1, 2000 - Aug 31, 2012
    NIH
    The functions of the US3 protein kinase of herpes simplex virus
    Role: Principal Investigator
    R01CA083939     (ROIZMAN, BERNARD)Jan 1, 2000 - Dec 31, 2010
    NIH
    FUNCTIONS FOR HERPES SIMPLEX VIRUS ICP22 AND US1.5
    Role: Principal Investigator
    R37CA078766     (ROIZMAN, BERNARD)Jul 29, 1998 - Apr 30, 2013
    NIH
    Dissection of the Functions of Herpes Simplex Virus ICPO
    Role: Principal Investigator
    R01CA078766     (ROIZMAN, BERNARD)Jul 29, 1998 - Apr 30, 2003
    NIH
    DISSECTION OF THE FUNCTIONS OF HERPES SIMPLEX VIRUS ICPO
    Role: Principal Investigator
    P01CA071933     (WHITLEY, RICHARD J.)Aug 15, 1997 - Jun 30, 2015
    NIH
    Engineered HSV For Treatment of Malignant Glioma
    Role: Co-Principal Investigator
    R35CA047451     (ROIZMAN, BERNARD)May 15, 1988 - Feb 28, 2002
    NIH
    MOLECULAR BIOLOGY OF HERPES SIMPLEX VIRUSES
    Role: Principal Investigator
    P01AI024009     (ROIZMAN, BERNARD)Jul 1, 1987 - May 31, 1997
    NIH
    HSV VACCINE DESIGN--ABLATION OF VIRULENCE AND LATENCY
    Role: Principal Investigator
    T32AI007182     (ROIZMAN, BERNARD)Jul 1, 1979 - Jun 30, 1990
    NIH
    VIROLOGY
    Role: Principal Investigator
    R01AI015488     (ROIZMAN, BERNARD)Dec 1, 1978 - Nov 30, 1991
    NIH
    HERPES SIMPLEX VIRUS MULTIPLICATION
    Role: Principal Investigator
    T32CA009241     (ROIZMAN, BERNARD)Jul 1, 1978 - Dec 31, 1990
    NIH
    GRADUATE TRAINING PROGRAM IN VIRAL ONCOLOGY
    Role: Principal Investigator
    P01CA019264     (ROIZMAN, BERNARD)Jun 30, 1976 - Jun 30, 1990
    NIH
    UCCRC: VIRAL ONCOLOGY PROGRAM
    Role: Principal Investigator
    R37CA008494     (ROIZMAN, BERNARD)Sep 1, 1975 - Feb 28, 1991
    NIH
    MECHANISMS OF VIRAL INFECTION IN RELATION TO CANCER
    Role: Principal Investigator
    R01CA008494     (ROIZMAN, BERNARD)Sep 1, 1975 - Feb 28, 1986
    NIH
    MECHANISMS OF VIRAL INFECTION IN RELATION TO CANCER
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhou X, Wang L, Zou W, Chen X, Roizman B, Zhou GG. hnRNPA2B1 Associated with Recruitment of RNA into Exosomes Plays a Key Role in Herpes Simplex Virus 1 Release from Infected Cells. J Virol. 2020 06 16; 94(13). PMID: 32295924; PMCID: PMC7307161.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    2. Calisher C, Carroll D, Colwell R, Corley RB, Daszak P, Enjuanes L, Farrar J, Field H, Golding J, Gorbalenya A, Haagmans B, Hughes JM, Karesh WB, Keusch GT, Lam SK, Lubroth J, Mackenzie JS, Madoff L, Mazet J, Palese P, Perlman S, Poon L, Roizman B, Saif L, Subbarao K, Turner M, Drosten C. Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19. Lancet. 2020 03 07; 395(10226):e42-e43. PMID: 32087122; PMCID: PMC7159294.
      Citations: 74     Fields:    Translation:HumansCellsPHPublic Health
    3. Huang R, Wu J, Zhou X, Jiang H, Guoying Zhou G, Roizman B. Herpes Simplex Virus 1 MicroRNA miR-H28 Exported to Uninfected Cells in Exosomes Restricts Cell-to-Cell Virus Spread by Inducing Gamma Interferon mRNA. J Virol. 2019 11 01; 93(21). PMID: 31413129; PMCID: PMC6803268.
      Citations: 18     Fields:    Translation:HumansCells
    4. She M, Jiang H, Chen X, Chen X, Liu X, Zhang X, Roizman B, Zhou GG. GADD45? Activated Early in the Course of Herpes Simplex Virus 1 Infection Suppresses the Activation of a Network of Innate Immunity Genes. J Virol. 2019 04 01; 93(7). PMID: 30700604; PMCID: PMC6430557.
      Citations: 3     Fields:    Translation:AnimalsCells
    5. Liu Y, Liu Y, Wu J, Roizman B, Zhou GG. Innate responses to gene knockouts impact overlapping gene networks and vary with respect to resistance to viral infection. Proc Natl Acad Sci U S A. 2018 04 03; 115(14):E3230-E3237. PMID: 29559532; PMCID: PMC5889655.
      Citations: 8     Fields:    Translation:HumansCells
    6. Wang L, Chen X, Zhou X, Roizman B, Zhou GG. miRNAs Targeting ICP4 and Delivered to Susceptible Cells in Exosomes Block HSV-1 Replication in a Dose-Dependent Manner. Mol Ther. 2018 04 04; 26(4):1032-1039. PMID: 29526650; PMCID: PMC6080130.
      Citations: 9     Fields:    Translation:HumansCells
    7. Liu Y, Qu L, Liu Y, Roizman B, Zhou GG. PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):E6902-E6911. PMID: 28760986; PMCID: PMC5565464.
      Citations: 19     Fields:    Translation:HumansCells
    8. Xu P, Roizman B. The SP100 component of ND10 enhances accumulation of PML and suppresses replication and the assembly of HSV replication compartments. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):E3823-E3829. PMID: 28439026; PMCID: PMC5441741.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    9. Xu P, Mallon S, Roizman B. PML plays both inimical and beneficial roles in HSV-1 replication. Proc Natl Acad Sci U S A. 2016 May 24; 113(21):E3022-8. PMID: 27162364; PMCID: PMC4889406.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    10. Han Z, Liu X, Chen X, Zhou X, Du T, Roizman B, Zhou G. miR-H28 and miR-H29 expressed late in productive infection are exported and restrict HSV-1 replication and spread in recipient cells. Proc Natl Acad Sci U S A. 2016 Feb 16; 113(7):E894-901. PMID: 26831114; PMCID: PMC4763765.
      Citations: 46     Fields:    Translation:HumansCells
    11. Roizman B. The Maturation of a Scientist: An Autobiography. Annu Rev Virol. 2015 Nov; 2(1):1-23. PMID: 26958904.
      Citations:    Fields:    Translation:HumansCells
    12. Shu M, Du T, Zhou G, Roizman B. Role of activating transcription factor 3 in the synthesis of latency-associated transcript and maintenance of herpes simplex virus 1 in latent state in ganglia. Proc Natl Acad Sci U S A. 2015 Sep 29; 112(39):E5420-6. PMID: 26305977; PMCID: PMC4593112.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    13. Roizman B, Zhou G. The 3 facets of regulation of herpes simplex virus gene expression: A critical inquiry. Virology. 2015 May; 479-480:562-7. PMID: 25771487; PMCID: PMC4424108.
      Citations: 33     Fields:    Translation:Cells
    14. Shu M, Taddeo B, Roizman B. Tristetraprolin Recruits the Herpes Simplex Virion Host Shutoff RNase to AU-Rich Elements in Stress Response mRNAs To Enable Their Cleavage. J Virol. 2015 May; 89(10):5643-50. PMID: 25762736; PMCID: PMC4442522.
      Citations: 14     Fields:    Translation:HumansCells
    15. Du T, Han Z, Zhou G, Zhou G, Roizman B. Patterns of accumulation of miRNAs encoded by herpes simplex virus during productive infection, latency, and on reactivation. Proc Natl Acad Sci U S A. 2015 Jan 06; 112(1):E49-55. PMID: 25535379; PMCID: PMC4291656.
      Citations: 33     Fields:    Translation:AnimalsCells
    16. Kalamvoki M, Du T, Roizman B. Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):E4991-6. PMID: 25368198; PMCID: PMC4246290.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    17. Zhu Z, Du T, Zhou G, Roizman B. The stability of herpes simplex virus 1 ICP0 early after infection is defined by the RING finger and the UL13 protein kinase. J Virol. 2014 May; 88(10):5437-43. PMID: 24574411; PMCID: PMC4019132.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    18. Kalamvoki M, Roizman B. HSV-1 degrades, stabilizes, requires, or is stung by STING depending on ICP0, the US3 protein kinase, and cell derivation. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):E611-7. PMID: 24449861; PMCID: PMC3918790.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    19. Widau RC, Parekh AD, Ranck MC, Golden DW, Kumar KA, Sood RF, Pitroda SP, Liao Z, Huang X, Darga TE, Xu D, Huang L, Andrade J, Roizman B, Weichselbaum RR, Khodarev NN. RIG-I-like receptor LGP2 protects tumor cells from ionizing radiation. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):E484-91. PMID: 24434553; PMCID: PMC3910628.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    20. Shu M, Taddeo B, Roizman B. The nuclear-cytoplasmic shuttling of virion host shutoff RNase is enabled by pUL47 and an embedded nuclear export signal and defines the sites of degradation of AU-rich and stable cellular mRNAs. J Virol. 2013 Dec; 87(24):13569-78. PMID: 24109211; PMCID: PMC3838220.
      Citations: 15     Fields:    Translation:HumansCells
    21. Gu H, Zheng Y, Roizman B. Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention. J Virol. 2013 Sep; 87(18):10244-54. PMID: 23864622; PMCID: PMC3753982.
      Citations: 19     Fields:    Translation:HumansCells
    22. Du T, Zhou G, Roizman B. Modulation of reactivation of latent herpes simplex virus 1 in ganglionic organ cultures by p300/CBP and STAT3. Proc Natl Acad Sci U S A. 2013 Jul 09; 110(28):E2621-8. PMID: 23788661; PMCID: PMC3710862.
      Citations: 34     Fields:    Translation:HumansCells
    23. Zhou G, Du T, Roizman B. The role of the CoREST/REST repressor complex in herpes simplex virus 1 productive infection and in latency. Viruses. 2013 Apr 29; 5(5):1208-18. PMID: 23628827; PMCID: PMC3712303.
      Citations: 16     Fields:    Translation:HumansCells
    24. Shu M, Taddeo B, Zhang W, Roizman B. Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein. Proc Natl Acad Sci U S A. 2013 Apr 30; 110(18):E1669-75. PMID: 23589852; PMCID: PMC3645526.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    25. Taddeo B, Zhang W, Roizman B. The herpes simplex virus host shutoff RNase degrades cellular and viral mRNAs made before infection but not viral mRNA made after infection. J Virol. 2013 Apr; 87(8):4516-22. PMID: 23388723; PMCID: PMC3624343.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    26. Zhou G, Du T, Roizman B. HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):E498-506. PMID: 23341636; PMCID: PMC3568314.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    27. Sciortino MT, Parisi T, Siracusano G, Mastino A, Taddeo B, Roizman B. The virion host shutoff RNase plays a key role in blocking the activation of protein kinase R in cells infected with herpes simplex virus 1. J Virol. 2013 Mar; 87(6):3271-6. PMID: 23302873; PMCID: PMC3592158.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    28. Roizman B, Whitley RJ. An inquiry into the molecular basis of HSV latency and reactivation. Annu Rev Microbiol. 2013; 67:355-74. PMID: 24024635.
      Citations: 112     Fields:    Translation:HumansAnimalsCells
    29. Mallon S, Wakim BT, Roizman B. Use of biotinylated plasmid DNA as a surrogate for HSV DNA to identify proteins that repress or activate viral gene expression. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):E3549-57. PMID: 23223531; PMCID: PMC3529035.
      Citations: 4     Fields:    Translation:HumansCells
    30. Kalamvoki M, Gu H, Roizman B. Overexpression of the ubiquitin-specific protease 7 resulting from transfection or mutations in the ICP0 binding site accelerates rather than depresses herpes simplex virus 1 gene expression. J Virol. 2012 Dec; 86(23):12871-8. PMID: 22993145; PMCID: PMC3497670.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    31. Du T, Zhou G, Roizman B. Induction of apoptosis accelerates reactivation of latent HSV-1 in ganglionic organ cultures and replication in cell cultures. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14616-21. PMID: 22908263; PMCID: PMC3437834.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    32. Khodarev NN, Roizman B, Weichselbaum RR. Molecular pathways: interferon/stat1 pathway: role in the tumor resistance to genotoxic stress and aggressive growth. Clin Cancer Res. 2012 Jun 01; 18(11):3015-21. PMID: 22615451.
      Citations: 102     Fields:    Translation:HumansCells
    33. Du T, Zhou G, Roizman B. HSV-1 gene expression from reactivated ganglia is disordered and concurrent with suppression of latency-associated transcript and miRNAs. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18820-4. PMID: 22065742; PMCID: PMC3219146.
      Citations: 78     Fields:    Translation:AnimalsCells
    34. Roizman B, Zhou G, Du T. Checkpoints in productive and latent infections with herpes simplex virus 1: conceptualization of the issues. J Neurovirol. 2011 Dec; 17(6):512-7. PMID: 22052379.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    35. Wang X, Patenode C, Roizman B. US3 protein kinase of HSV-1 cycles between the cytoplasm and nucleus and interacts with programmed cell death protein 4 (PDCD4) to block apoptosis. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14632-6. PMID: 21844356; PMCID: PMC3167522.
      Citations: 33     Fields:    Translation:HumansCells
    36. Kalamvoki M, Roizman B. The histone acetyltransferase CLOCK is an essential component of the herpes simplex virus 1 transcriptome that includes TFIID, ICP4, ICP27, and ICP22. J Virol. 2011 Sep; 85(18):9472-7. PMID: 21734043; PMCID: PMC3165755.
      Citations: 43     Fields:    Translation:HumansCells
    37. Advani SJ, Markert JM, Sood RF, Samuel S, Gillespie GY, Shao MY, Roizman B, Weichselbaum RR. Increased oncolytic efficacy for high-grade gliomas by optimal integration of ionizing radiation into the replicative cycle of HSV-1. Gene Ther. 2011 Nov; 18(11):1098-102. PMID: 21544094; PMCID: PMC8670556.
      Citations: 24     Fields:    Translation:AnimalsCells
    38. Roizman B. The checkpoints of viral gene expression in productive and latent infection: the role of the HDAC/CoREST/LSD1/REST repressor complex. J Virol. 2011 Aug; 85(15):7474-82. PMID: 21450817; PMCID: PMC3147896.
      Citations: 45     Fields:    Translation:HumansAnimals
    39. Zhou G, Te D, Roizman B. The CoREST/REST repressor is both necessary and inimical for expression of herpes simplex virus genes. mBio. 2010 Dec 28; 2(1):e00313-10. PMID: 21221247; PMCID: PMC3018283.
      Citations: 25     Fields:    Translation:HumansCells
    40. Kalamvoki M, Roizman B. Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression. Proc Natl Acad Sci U S A. 2010 Oct 12; 107(41):17721-6. PMID: 20876123; PMCID: PMC2955081.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    41. Du T, Zhou G, Khan S, Gu H, Roizman B. Disruption of HDAC/CoREST/REST repressor by dnREST reduces genome silencing and increases virulence of herpes simplex virus. Proc Natl Acad Sci U S A. 2010 Sep 07; 107(36):15904-9. PMID: 20798038; PMCID: PMC2936609.
      Citations: 36     Fields:    Translation:Cells
    42. Kalamvoki M, Roizman B. Interwoven roles of cyclin D3 and cdk4 recruited by ICP0 and ICP4 in the expression of herpes simplex virus genes. J Virol. 2010 Oct; 84(19):9709-17. PMID: 20660182; PMCID: PMC2937768.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    43. Taddeo B, Zhang W, Roizman B. Role of herpes simplex virus ICP27 in the degradation of mRNA by virion host shutoff RNase. J Virol. 2010 Oct; 84(19):10182-90. PMID: 20631134; PMCID: PMC2937800.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    44. Jovasevic V, Roizman B. The novel HSV-1 US5-1 RNA is transcribed off a domain encoding US5, US4, US3, US2 and alpha22. Virol J. 2010 May 21; 7:103. PMID: 20492679; PMCID: PMC2887431.
      Citations: 4     Fields:    Translation:AnimalsCells
    45. Kalamvoki M, Roizman B. Role of herpes simplex virus ICP0 in the transactivation of genes introduced by infection or transfection: a reappraisal. J Virol. 2010 May; 84(9):4222-8. PMID: 20164233; PMCID: PMC2863771.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    46. Gu H, Poon AP, Roizman B. During its nuclear phase the multifunctional regulatory protein ICP0 undergoes proteolytic cleavage characteristic of polyproteins. Proc Natl Acad Sci U S A. 2009 Nov 10; 106(45):19132-7. PMID: 19850872; PMCID: PMC2776466.
      Citations: 15     Fields:    Translation:HumansCells
    47. Kalamvoki M, Roizman B. ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14576-80. PMID: 19706544; PMCID: PMC2732861.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    48. Taddeo B, Zhang W, Roizman B. The virion-packaged endoribonuclease of herpes simplex virus 1 cleaves mRNA in polyribosomes. Proc Natl Acad Sci U S A. 2009 Jul 21; 106(29):12139-44. PMID: 19584246; PMCID: PMC2715532.
      Citations: 12     Fields:    Translation:HumansCells
    49. Efimova EV, Liang H, Pitroda SP, Labay E, Darga TE, Levina V, Lokshin A, Roizman B, Weichselbaum RR, Khodarev NN. Radioresistance of Stat1 over-expressing tumour cells is associated with suppressed apoptotic response to cytotoxic agents and increased IL6-IL8 signalling. Int J Radiat Biol. 2009 May; 85(5):421-31. PMID: 19437244; PMCID: PMC2690884.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    50. Gu H, Roizman B. Engagement of the lysine-specific demethylase/HDAC1/CoREST/REST complex by herpes simplex virus 1. J Virol. 2009 May; 83(9):4376-85. PMID: 19193804; PMCID: PMC2668468.
      Citations: 42     Fields:    Translation:Cells
    51. Kalamvoki M, Roizman B. Nuclear retention of ICP0 in cells exposed to HDAC inhibitor or transfected with DNA before infection with herpes simplex virus 1. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20488-93. PMID: 19073918; PMCID: PMC2629265.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    52. Davison AJ, Eberle R, Ehlers B, Hayward GS, McGeoch DJ, Minson AC, Pellett PE, Roizman B, Studdert MJ, Thiry E. The order Herpesvirales. Arch Virol. 2009; 154(1):171-7. PMID: 19066710; PMCID: PMC3552636.
      Citations: 337     Fields:    Translation:HumansAnimalsCells
    53. Weichselbaum RR, Ishwaran H, Yoon T, Nuyten DS, Baker SW, Khodarev N, Su AW, Shaikh AY, Roach P, Kreike B, Roizman B, Bergh J, Pawitan Y, van de Vijver MJ, Minn AJ. An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18490-5. PMID: 19001271; PMCID: PMC2587578.
      Citations: 308     Fields:    Translation:HumansAnimalsCells
    54. Gu H, Roizman B. The two functions of herpes simplex virus 1 ICP0, inhibition of silencing by the CoREST/REST/HDAC complex and degradation of PML, are executed in tandem. J Virol. 2009 Jan; 83(1):181-7. PMID: 18945770; PMCID: PMC2612314.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    55. Durand LO, Roizman B. Role of cdk9 in the optimization of expression of the genes regulated by ICP22 of herpes simplex virus 1. J Virol. 2008 Nov; 82(21):10591-9. PMID: 18753202; PMCID: PMC2573194.
      Citations: 35     Fields:    Translation:HumansCells
    56. Liang L, Roizman B. Expression of gamma interferon-dependent genes is blocked independently by virion host shutoff RNase and by US3 protein kinase. J Virol. 2008 May; 82(10):4688-96. PMID: 18321964; PMCID: PMC2346744.
      Citations: 23     Fields:    Translation:HumansCells
    57. Smith-Donald BA, Durand LO, Roizman B. Role of cellular phosphatase cdc25C in herpes simplex virus 1 replication. J Virol. 2008 May; 82(9):4527-32. PMID: 18272575; PMCID: PMC2293048.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    58. Smith-Donald BA, Roizman B. The interaction of herpes simplex virus 1 regulatory protein ICP22 with the cdc25C phosphatase is enabled in vitro by viral protein kinases US3 and UL13. J Virol. 2008 May; 82(9):4533-43. PMID: 18272572; PMCID: PMC2293044.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    59. Jovasevic V, Liang L, Roizman B. Proteolytic cleavage of VP1-2 is required for release of herpes simplex virus 1 DNA into the nucleus. J Virol. 2008 Apr; 82(7):3311-9. PMID: 18216103; PMCID: PMC2268474.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    60. Kalamvoki M, Qu J, Roizman B. Translocation and colocalization of ICP4 and ICP0 in cells infected with herpes simplex virus 1 mutants lacking glycoprotein E, glycoprotein I, or the virion host shutoff product of the UL41 gene. J Virol. 2008 Feb; 82(4):1701-13. PMID: 18057247; PMCID: PMC2258734.
      Citations: 16     Fields:    Translation:HumansCells
    61. Gu H, Roizman B. Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complex. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17134-9. PMID: 17939992; PMCID: PMC2040395.
      Citations: 131     Fields:    Translation:HumansAnimalsCells
    62. Yang K, Poon AP, Roizman B, Baines JD. Temperature-sensitive mutations in the putative herpes simplex virus type 1 terminase subunits pUL15 and pUL33 preclude viral DNA cleavage/packaging and interaction with pUL28 at the nonpermissive temperature. J Virol. 2008 Jan; 82(1):487-94. PMID: 17913813; PMCID: PMC2224384.
      Citations: 14     Fields:    Translation:Cells
    63. Khodarev NN, Minn AJ, Efimova EV, Darga TE, Labay E, Beckett M, Mauceri HJ, Roizman B, Weichselbaum RR. Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells. Cancer Res. 2007 Oct 01; 67(19):9214-20. PMID: 17909027.
      Citations: 76     Fields:    Translation:HumansAnimals
    64. Veerapong J, Bickenbach KA, Shao MY, Smith KD, Posner MC, Roizman B, Weichselbaum RR. Systemic delivery of (gamma1)34.5-deleted herpes simplex virus-1 selectively targets and treats distant human xenograft tumors that express high MEK activity. Cancer Res. 2007 Sep 01; 67(17):8301-6. PMID: 17804745.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    65. Sciortino MT, Taddeo B, Medici MA, Mastino A, Roizman B, Giuffrè-Cuculletto M. Replication-competent herpes simplex virus 1 isolates selected from cells transfected with a bacterial artificial chromosome DNA lacking only the UL49 gene vary with respect to the defect in the UL41 gene encoding host shutoff RNase. J Virol. 2007 Oct; 81(20):10924-32. PMID: 17670820; PMCID: PMC2045545.
      Citations: 34     Fields:    Translation:HumansCells
    66. Benetti L, Roizman B. In transduced cells, the US3 protein kinase of herpes simplex virus 1 precludes activation and induction of apoptosis by transfected procaspase 3. J Virol. 2007 Oct; 81(19):10242-8. PMID: 17634220; PMCID: PMC2045497.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    67. Skelly CL, Chandiwal A, Vosicky JE, Weichselbaum RR, Roizman B. Attenuated herpes simplex virus 1 blocks arterial apoptosis and intimal hyperplasia induced by balloon angioplasty and reduced blood flow. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12474-8. PMID: 17626787; PMCID: PMC1941493.
      Citations: 9     Fields:    Translation:AnimalsCells
    68. Taddeo B, Sciortino MT, Zhang W, Roizman B. Interaction of herpes simplex virus RNase with VP16 and VP22 is required for the accumulation of the protein but not for accumulation of mRNA. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12163-8. PMID: 17620619; PMCID: PMC1924560.
      Citations: 41     Fields:    Translation:HumansCells
    69. Kari I, Johansson B, Peri P, He B, Roizman B, Hukkanen V, Syrjänen S. Antisense RNA directed to the human papillomavirus type 16 E7 mRNA from herpes simplex virus type 1 derived vectors is expressed in CaSki cells and downregulates E7 mRNA. Virol J. 2007 Jun 04; 4:47. PMID: 17547759; PMCID: PMC1892547.
      Citations: 2     Fields:    Translation:HumansCells
    70. Kalamvoki M, Roizman B. Bcl-2 blocks accretion or depletion of stored calcium but has no effect on the redistribution of IP3 receptor I mediated by glycoprotein E of herpes simplex virus 1. J Virol. 2007 Jun; 81(12):6316-25. PMID: 17409148; PMCID: PMC1900130.
      Citations: 7     Fields:    Translation:HumansCells
    71. Zhou G, Roizman B. Separation of receptor-binding and profusogenic domains of glycoprotein D of herpes simplex virus 1 into distinct interacting proteins. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):4142-6. PMID: 17360490; PMCID: PMC1820722.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    72. Poon AP, Roizman B. Mapping of key functions of the herpes simplex virus 1 U(S)3 protein kinase: the U(S)3 protein can form functional heteromultimeric structures derived from overlapping truncated polypeptides. J Virol. 2007 Feb; 81(4):1980-9. PMID: 17151133; PMCID: PMC1797600.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    73. Baines JD, Wills E, Jacob RJ, Pennington J, Roizman B. Glycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane. J Virol. 2007 Jan; 81(2):800-12. PMID: 17079321; PMCID: PMC1797462.
      Citations: 28     Fields:    Translation:HumansCells
    74. Advani SJ, Mezhir JJ, Roizman B, Weichselbaum RR. ReVOLT: radiation-enhanced viral oncolytic therapy. Int J Radiat Oncol Biol Phys. 2006 Nov 01; 66(3):637-46. PMID: 17011442.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    75. Taddeo B, Roizman B. The virion host shutoff protein (UL41) of herpes simplex virus 1 is an endoribonuclease with a substrate specificity similar to that of RNase A. J Virol. 2006 Sep; 80(18):9341-5. PMID: 16940547; PMCID: PMC1563938.
      Citations: 55     Fields:    Translation:Cells
    76. Liang L, Roizman B. Herpes simplex virus 1 precludes replenishment of the short-lived receptor of tumor necrosis factor alpha by virion host shutoff-dependent degradation of its mRNA. J Virol. 2006 Aug; 80(15):7756-9. PMID: 16840355; PMCID: PMC1563695.
      Citations: 10     Fields:    Translation:HumansCells
    77. Campadelli-Fiume G, Roizman B. The egress of herpesviruses from cells: the unanswered questions. J Virol. 2006 Jul; 80(13):6716-7; author replies 6717-9. PMID: 16775362; PMCID: PMC1488928.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    78. Poon AP, Gu H, Roizman B. ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression. Proc Natl Acad Sci U S A. 2006 Jun 27; 103(26):9993-8. PMID: 16785443; PMCID: PMC1502567.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    79. Kamiyama H, Zhou G, Roizman B. Herpes simplex virus 1 recombinant virions exhibiting the amino terminal fragment of urokinase-type plasminogen activator can enter cells via the cognate receptor. Gene Ther. 2006 Apr; 13(7):621-9. PMID: 16292350.
      Citations: 27     Fields:    Translation:HumansCells
    80. Benetti L, Roizman B. Protein kinase B/Akt is present in activated form throughout the entire replicative cycle of deltaU(S)3 mutant virus but only at early times after infection with wild-type herpes simplex virus 1. J Virol. 2006 Apr; 80(7):3341-8. PMID: 16537601; PMCID: PMC1440418.
      Citations: 46     Fields:    Translation:HumansCells
    81. Poon AP, Benetti L, Roizman B. U(S)3 and U(S)3.5 protein kinases of herpes simplex virus 1 differ with respect to their functions in blocking apoptosis and in virion maturation and egress. J Virol. 2006 Apr; 80(8):3752-64. PMID: 16571792; PMCID: PMC1440442.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    82. Liang Y, Roizman B. State and role of SRC family kinases in replication of herpes simplex virus 1. J Virol. 2006 Apr; 80(7):3349-59. PMID: 16537602; PMCID: PMC1440421.
      Citations: 12     Fields:    Translation:AnimalsCells
    83. Zhou G, Roizman B. Construction and properties of a herpes simplex virus 1 designed to enter cells solely via the IL-13alpha2 receptor. Proc Natl Acad Sci U S A. 2006 Apr 04; 103(14):5508-13. PMID: 16554374; PMCID: PMC1459385.
      Citations: 53     Fields:    Translation:AnimalsCells
    84. Taddeo B, Zhang W, Roizman B. The U(L)41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2827-32. PMID: 16477041; PMCID: PMC1413801.
      Citations: 65     Fields:    Translation:HumansCells
    85. Smith KD, Mezhir JJ, Bickenbach K, Veerapong J, Charron J, Posner MC, Roizman B, Weichselbaum RR. Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1. J Virol. 2006 Feb; 80(3):1110-20. PMID: 16414988; PMCID: PMC1346955.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    86. Mezhir JJ, Advani SJ, Smith KD, Darga TE, Poon AP, Schmidt H, Posner MC, Roizman B, Weichselbaum RR. Ionizing radiation activates late herpes simplex virus 1 promoters via the p38 pathway in tumors treated with oncolytic viruses. Cancer Res. 2005 Oct 15; 65(20):9479-84. PMID: 16230412.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    87. Roizman B, Gu H, Mandel G. The first 30 minutes in the life of a virus: unREST in the nucleus. Cell Cycle. 2005 Aug; 4(8):1019-21. PMID: 16082207.
      Citations: 38     Fields:    Translation:HumansCells
    88. Hellums EK, Markert JM, Parker JN, He B, Perbal B, Roizman B, Whitley RJ, Langford CP, Bharara S, Gillespie GY. Increased efficacy of an interleukin-12-secreting herpes simplex virus in a syngeneic intracranial murine glioma model. Neuro Oncol. 2005 Jul; 7(3):213-24. PMID: 16053696; PMCID: PMC1871915.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    89. Poon AP, Roizman B. Herpes simplex virus 1 ICP22 regulates the accumulation of a shorter mRNA and of a truncated US3 protein kinase that exhibits altered functions. J Virol. 2005 Jul; 79(13):8470-9. PMID: 15956590; PMCID: PMC1143707.
      Citations: 24     Fields:    Translation:AnimalsCells
    90. Durand LO, Advani SJ, Poon AP, Roizman B. The carboxyl-terminal domain of RNA polymerase II is phosphorylated by a complex containing cdk9 and infected-cell protein 22 of herpes simplex virus 1. J Virol. 2005 Jun; 79(11):6757-62. PMID: 15890914; PMCID: PMC1112163.
      Citations: 43     Fields:    Translation:HumansCells
    91. Gu H, Liang Y, Mandel G, Roizman B. Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells. Proc Natl Acad Sci U S A. 2005 May 24; 102(21):7571-6. PMID: 15897453; PMCID: PMC1140450.
      Citations: 140     Fields:    Translation:HumansCells
    92. Zhou G, Roizman B. Characterization of a recombinant herpes simplex virus 1 designed to enter cells via the IL13Ralpha2 receptor of malignant glioma cells. J Virol. 2005 May; 79(9):5272-7. PMID: 15827141; PMCID: PMC1082778.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    93. Liang Y, Kurakin A, Roizman B. Herpes simplex virus 1 infected cell protein 0 forms a complex with CIN85 and Cbl and mediates the degradation of EGF receptor from cell surfaces. Proc Natl Acad Sci U S A. 2005 Apr 19; 102(16):5838-43. PMID: 15824310; PMCID: PMC556299.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    94. Baldwin ZK, Chandiwal A, Balasubramanian V, Pearce BJ, Curi MA, Skelly CL, Huang WW, Vosicky JE, Roizman B, Weichselbaum RR, Schwartz LB. Modulation of vascular remodeling induced by a brief intraluminal exposure to the recombinant R7020 strain of Herpes simplex-1. J Vasc Surg. 2005 Jan; 41(1):115-21. PMID: 15696053.
      Citations: 2     Fields:    Translation:AnimalsCells
    95. Esclatine A, Taddeo B, Roizman B. The UL41 protein of herpes simplex virus mediates selective stabilization or degradation of cellular mRNAs. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18165-70. PMID: 15596716; PMCID: PMC539803.
      Citations: 48     Fields:    Translation:HumansCells
    96. Pagano JS, Blaser M, Buendia MA, Damania B, Khalili K, Raab-Traub N, Roizman B. Infectious agents and cancer: criteria for a causal relation. Semin Cancer Biol. 2004 Dec; 14(6):453-71. PMID: 15489139.
      Citations: 112     Fields:    Translation:HumansAnimalsCells
    97. Taddeo B, Zhang W, Lakeman F, Roizman B. Cells lacking NF-kappaB or in which NF-kappaB is not activated vary with respect to ability to sustain herpes simplex virus 1 replication and are not susceptible to apoptosis induced by a replication-incompetent mutant virus. J Virol. 2004 Nov; 78(21):11615-21. PMID: 15479802; PMCID: PMC523294.
      Citations: 22     Fields:    Translation:AnimalsCells
    98. Taddeo B, Esclatine A, Roizman B. Post-transcriptional processing of cellular RNAs in herpes simplex virus-infected cells. Biochem Soc Trans. 2004 Nov; 32(Pt 5):697-701. PMID: 15493991.
      Citations: 18     Fields:    Translation:HumansCells
    99. Esclatine A, Taddeo B, Roizman B. Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs. J Virol. 2004 Aug; 78(16):8582-92. PMID: 15280467; PMCID: PMC479066.
      Citations: 56     Fields:    Translation:HumansCells
    100. Benetti L, Roizman B. Herpes simplex virus protein kinase US3 activates and functionally overlaps protein kinase A to block apoptosis. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9411-6. PMID: 15192152; PMCID: PMC438990.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    101. Chee AV, Roizman B. Herpes simplex virus 1 gene products occlude the interferon signaling pathway at multiple sites. J Virol. 2004 Apr; 78(8):4185-96. PMID: 15047834; PMCID: PMC374303.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    102. Hagglund R, Roizman B. Role of ICP0 in the strategy of conquest of the host cell by herpes simplex virus 1. J Virol. 2004 Mar; 78(5):2169-78. PMID: 14963113; PMCID: PMC369245.
      Citations: 126     Fields:    Translation:AnimalsCells
    103. Esclatine A, Taddeo B, Evans L, Roizman B. The herpes simplex virus 1 UL41 gene-dependent destabilization of cellular RNAs is selective and may be sequence-specific. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3603-8. PMID: 14993598; PMCID: PMC373509.
      Citations: 62     Fields:    Translation:HumansCells
    104. Khodarev NN, Beckett M, Labay E, Darga T, Roizman B, Weichselbaum RR. STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells. Proc Natl Acad Sci U S A. 2004 Feb 10; 101(6):1714-9. PMID: 14755057; PMCID: PMC341831.
      Citations: 153     Fields:    Translation:HumansAnimalsCells
    105. Hagglund R, Roizman B. Herpes simplex virus 1 mutant in which the ICP0 HUL-1 E3 ubiquitin ligase site is disrupted stabilizes cdc34 but degrades D-type cyclins and exhibits diminished neurotoxicity. J Virol. 2003 Dec; 77(24):13194-202. PMID: 14645576; PMCID: PMC296091.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    106. Poon AP, Liang Y, Roizman B. Herpes simplex virus 1 gene expression is accelerated by inhibitors of histone deacetylases in rabbit skin cells infected with a mutant carrying a cDNA copy of the infected-cell protein no. 0. J Virol. 2003 Dec; 77(23):12671-8. PMID: 14610189; PMCID: PMC262575.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    107. Advani SJ, Durand LO, Weichselbaum RR, Roizman B. Oct-1 is posttranslationally modified and exhibits reduced capacity to bind cognate sites at late times after infection with herpes simplex virus 1. J Virol. 2003 Nov; 77(22):11927-32. PMID: 14581529; PMCID: PMC254286.
      Citations: 6     Fields:    Translation:HumansCells
    108. Taddeo B, Luo TR, Zhang W, Roizman B. Activation of NF-kappaB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12408-13. PMID: 14530405; PMCID: PMC218771.
      Citations: 43     Fields:    Translation:AnimalsCells
    109. Gu H, Roizman B. The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8963-8. PMID: 12855769; PMCID: PMC166421.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    110. Chee AV, Lopez P, Pandolfi PP, Roizman B. Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects. J Virol. 2003 Jun; 77(12):7101-5. PMID: 12768029; PMCID: PMC156157.
      Citations: 113     Fields:    Translation:AnimalsCells
    111. Taddeo B, Esclatine A, Zhang W, Roizman B. The stress-inducible immediate-early responsive gene IEX-1 is activated in cells infected with herpes simplex virus 1, but several viral mechanisms, including 3' degradation of its RNA, preclude expression of the gene. J Virol. 2003 Jun; 77(11):6178-87. PMID: 12743274; PMCID: PMC154982.
      Citations: 31     Fields:    Translation:HumansCells
    112. Benetti L, Munger J, Roizman B. The herpes simplex virus 1 US3 protein kinase blocks caspase-dependent double cleavage and activation of the proapoptotic protein BAD. J Virol. 2003 Jun; 77(11):6567-73. PMID: 12743316; PMCID: PMC155029.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    113. Curi MA, Skelly CL, Meyerson SL, Baldwin ZK, Balasubramanian V, Advani SJ, Glagov S, Roizman B, Weichselbaum RR, Schwartz LB. Sustained inhibition of experimental neointimal hyperplasia with a genetically modified herpes simplex virus. J Vasc Surg. 2003 Jun; 37(6):1294-300. PMID: 12764278.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    114. Advani SJ, Weichselbaum RR, Roizman B. Herpes simplex virus 1 activates cdc2 to recruit topoisomerase II alpha for post-DNA synthesis expression of late genes. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4825-30. PMID: 12665617; PMCID: PMC153640.
      Citations: 29     Fields:    Translation:HumansCells
    115. Zhou G, Avitabile E, Campadelli-Fiume G, Roizman B. The domains of glycoprotein D required to block apoptosis induced by herpes simplex virus 1 are largely distinct from those involved in cell-cell fusion and binding to nectin1. J Virol. 2003 Mar; 77(6):3759-67. PMID: 12610150; PMCID: PMC149540.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    116. Khodarev NN, Park J, Kataoka Y, Nodzenski E, Hellman S, Roizman B, Weichselbaum RR, Pelizzari CA. Receiver operating characteristic analysis: a general tool for DNA array data filtration and performance estimation. Genomics. 2003 Feb; 81(2):202-9. PMID: 12620398.
      Citations: 12     Fields:    
    117. Munger J, Hagglund R, Roizman B. Infected cell protein No. 22 is subject to proteolytic cleavage by caspases activated by a mutant that induces apoptosis. Virology. 2003 Jan 20; 305(2):364-70. PMID: 12573581.
      Citations: 13     Fields:    Translation:HumansCells
    118. Taddeo B, Esclatine A, Roizman B. The patterns of accumulation of cellular RNAs in cells infected with a wild-type and a mutant herpes simplex virus 1 lacking the virion host shutoff gene. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):17031-6. PMID: 12481033; PMCID: PMC139264.
      Citations: 51     Fields:    Translation:HumansCells
    119. Zhou G, Ye GJ, Debinski W, Roizman B, Zhou G, Ye GJ, Debinski W, Roizman B. Engineered herpes simplex virus 1 is dependent on IL13Ralpha 2 receptor for cell entry and independent of glycoprotein D receptor interaction. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):15124-9. PMID: 12417744; PMCID: PMC137554.
      Citations: 48     Fields:    Translation:HumansCells
    120. Zhou G, Roizman B, Zhou G, Roizman B. Truncated forms of glycoprotein D of herpes simplex virus 1 capable of blocking apoptosis and of low-efficiency entry into cells form a heterodimer dependent on the presence of a cysteine located in the shared transmembrane domains. J Virol. 2002 Nov; 76(22):11469-75. PMID: 12388708; PMCID: PMC136777.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    121. Poon AP, Silverstein SJ, Roizman B, Poon AP, Silverstein SJ, Roizman B. An early regulatory function required in a cell type-dependent manner is expressed by the genomic but not the cDNA copy of the herpes simplex virus 1 gene encoding infected cell protein 0. J Virol. 2002 Oct; 76(19):9744-55. PMID: 12208953; PMCID: PMC136486.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    122. Advani SJ, Weichselbaum RR, Whitley RJ, Roizman B, Advani SJ, Weichselbaum RR, Whitley RJ, Roizman B. Friendly fire: redirecting herpes simplex virus-1 for therapeutic applications. Clin Microbiol Infect. 2002 Sep; 8(9):551-63. PMID: 12427216.
      Citations: 4     Fields:    Translation:HumansCells
    123. Lopez P, Jacob RJ, Roizman B, Lopez P, Jacob RJ, Roizman B. Overexpression of promyelocytic leukemia protein precludes the dispersal of ND10 structures and has no effect on accumulation of infectious herpes simplex virus 1 or its proteins. J Virol. 2002 Sep; 76(18):9355-67. PMID: 12186918; PMCID: PMC136451.
      Citations: 43     Fields:    Translation:HumansCells
    124. Whitley RJ, Roizman B. Herpes simplex viruses: is a vaccine tenable? J Clin Invest. 2002 Jul; 110(2):145-51. PMID: 12122103; PMCID: PMC151069.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    125. Trgovcich J, Johnson D, Roizman B, Trgovcich J, Johnson D, Roizman B. Cell surface major histocompatibility complex class II proteins are regulated by the products of the gamma(1)34.5 and U(L)41 genes of herpes simplex virus 1. J Virol. 2002 Jul; 76(14):6974-86. PMID: 12072498; PMCID: PMC136308.
      Citations: 46     Fields:    Translation:HumansCells
    126. Hagglund R, Roizman B, Hagglund R, Roizman B. Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-1-infected cell protein 0. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):7889-94. PMID: 12060736; PMCID: PMC122990.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    127. Sciortino MT, Taddeo B, Poon AP, Mastino A, Roizman B, Sciortino MT, Taddeo B, Poon AP, Mastino A, Roizman B. Of the three tegument proteins that package mRNA in herpes simplex virions, one (VP22) transports the mRNA to uninfected cells for expression prior to viral infection. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8318-23. PMID: 12060774; PMCID: PMC123065.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    128. Zhou G, Roizman B. Cation-independent mannose 6-phosphate receptor blocks apoptosis induced by herpes simplex virus 1 mutants lacking glycoprotein D and is likely the target of antiapoptotic activity of the glycoprotein. J Virol. 2002 Jun; 76(12):6197-204. PMID: 12021353; PMCID: PMC136186.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    129. Cassady KA, Gross M, Gillespie GY, Roizman B. Second-site mutation outside of the U(S)10-12 domain of Deltagamma(1)34.5 herpes simplex virus 1 recombinant blocks the shutoff of protein synthesis induced by activated protein kinase R and partially restores neurovirulence. J Virol. 2002 Feb; 76(3):942-9. PMID: 11773369; PMCID: PMC135782.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    130. Hagglund R, Van Sant C, Lopez P, Roizman B. Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):631-6. PMID: 11805320; PMCID: PMC117357.
      Citations: 66     Fields:    Translation:HumansCells
    131. Chung SM, Advani SJ, Bradley JD, Kataoka Y, Vashistha K, Yan SY, Markert JM, Gillespie GY, Whitley RJ, Roizman B, Weichselbaum RR, Chung SM, Advani SJ, Bradley JD, Kataoka Y, Vashistha K, Yan SY, Markert JM, Gillespie GY, Whitley RJ, Roizman B, Weichselbaum RR. The use of a genetically engineered herpes simplex virus (R7020) with ionizing radiation for experimental hepatoma. Gene Ther. 2002 Jan; 9(1):75-80. PMID: 11850725.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    132. Hagglund R, Munger J, Poon AP, Roizman B. U(S)3 protein kinase of herpes simplex virus 1 blocks caspase 3 activation induced by the products of U(S)1.5 and U(L)13 genes and modulates expression of transduced U(S)1.5 open reading frame in a cell type-specific manner. J Virol. 2002 Jan; 76(2):743-54. PMID: 11752164; PMCID: PMC136838.
      Citations: 29     Fields:    Translation:AnimalsCells
    133. Skelly CL, Curi MA, Meyerson SL, Woo DH, Hari D, Vosicky JE, Advani SJ, Mauceri HJ, Glagov S, Roizman B, Weichselbaum RR, Schwartz LB, Skelly CL, Curi MA, Meyerson SL, Woo DH, Hari D, Vosicky JE, Advani SJ, Mauceri HJ, Glagov S, Roizman B, Weichselbaum RR, Schwartz LB. Prevention of restenosis by a herpes simplex virus mutant capable of controlled long-term expression in vascular tissue in vivo. Gene Ther. 2001 Dec; 8(24):1840-6. PMID: 11821937.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    134. Advani SJ, Weichselbaum RR, Roizman B, Advani SJ, Weichselbaum RR, Roizman B. cdc2 cyclin-dependent kinase binds and phosphorylates herpes simplex virus 1 U(L)42 DNA synthesis processivity factor. J Virol. 2001 Nov; 75(21):10326-33. PMID: 11581401; PMCID: PMC114607.
      Citations: 22     Fields:    Translation:HumansCells
    135. Khodarev NN, Park JO, Yu J, Gupta N, Nodzenski E, Roizman B, Weichselbaum RR, Khodarev NN, Park JO, Yu J, Gupta N, Nodzenski E, Roizman B, Weichselbaum RR. Dose-dependent and independent temporal patterns of gene responses to ionizing radiation in normal and tumor cells and tumor xenografts. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12665-70. PMID: 11675498; PMCID: PMC60111.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    136. Advani SJ, Hagglund R, Weichselbaum RR, Roizman B, Advani SJ, Hagglund R, Weichselbaum RR, Roizman B. Posttranslational processing of infected cell proteins 0 and 4 of herpes simplex virus 1 is sequential and reflects the subcellular compartment in which the proteins localize. J Virol. 2001 Sep; 75(17):7904-12. PMID: 11483735; PMCID: PMC115034.
      Citations: 22     Fields:    Translation:HumansCells
    137. Sciortino MT, Suzuki M, Taddeo B, Roizman B, Sciortino MT, Suzuki M, Taddeo B, Roizman B. RNAs extracted from herpes simplex virus 1 virions: apparent selectivity of viral but not cellular RNAs packaged in virions. J Virol. 2001 Sep; 75(17):8105-16. PMID: 11483756; PMCID: PMC115055.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    138. Munger J, Roizman B, Munger J, Roizman B. The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10410-5. PMID: 11517326; PMCID: PMC56974.
      Citations: 83     Fields:    Translation:AnimalsCells
    139. Van Sant C, Hagglund R, Lopez P, Roizman B. The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8815-20. PMID: 11447293; PMCID: PMC37518.
      Citations: 68     Fields:    Translation:HumansCells
    140. Zhou G, Roizman B, Zhou G, Roizman B. The domains of glycoprotein D required to block apoptosis depend on whether glycoprotein D is present in the virions carrying herpes simplex virus 1 genome lacking the gene encoding the glycoprotein. J Virol. 2001 Jul; 75(13):6166-72. PMID: 11390618; PMCID: PMC114332.
      Citations: 14     Fields:    Translation:AnimalsCells
    141. Munger J, Chee AV, Roizman B. The U(S)3 protein kinase blocks apoptosis induced by the d120 mutant of herpes simplex virus 1 at a premitochondrial stage. J Virol. 2001 Jun; 75(12):5491-7. PMID: 11356956; PMCID: PMC114261.
      Citations: 65     Fields:    Translation:HumansCells
    142. Whitley RJ, Roizman B. Herpes simplex virus infections. Lancet. 2001 May 12; 357(9267):1513-8. PMID: 11377626.
      Citations: 394     Fields:    Translation:HumansCells
    143. Broberg E, Salmi A, He B, Roizman B, Hukkanen V, Setälä N, Röyttä M, Erälinna JP. Expression of interleukin-4 but not of interleukin-10 from a replicative herpes simplex virus type 1 viral vector precludes experimental allergic encephalomyelitis. Gene Ther. 2001 May; 8(10):769-77. PMID: 11420640.
      Citations: 7     Fields:    Translation:AnimalsCells
    144. Lopez P, Van Sant C, Roizman B. Requirements for the nuclear-cytoplasmic translocation of infected-cell protein 0 of herpes simplex virus 1. J Virol. 2001 Apr; 75(8):3832-40. PMID: 11264372; PMCID: PMC114874.
      Citations: 67     Fields:    Translation:HumansCells
    145. Roizman B, Whitley RJ. The nine ages of herpes simplex virus. Herpes. 2001 Mar; 8(1):23-7. PMID: 11867013.
      Citations: 13     Fields:    Translation:HumansCells
    146. Kawaguchi Y, Tanaka M, Yokoymama A, Matsuda G, Kato K, Kagawa H, Hirai K, Roizman B. Herpes simplex virus 1 alpha regulatory protein ICP0 functionally interacts with cellular transcription factor BMAL1. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1877-82. PMID: 11172044; PMCID: PMC29350.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    147. Van Sant C, Lopez P, Advani SJ, Roizman B. Role of cyclin D3 in the biology of herpes simplex virus 1 ICPO. J Virol. 2001 Feb; 75(4):1888-98. PMID: 11160688; PMCID: PMC115135.
      Citations: 31     Fields:    Translation:HumansCells
    148. Weichselbaum RR, Kufe DW, Advani SJ, Roizman B. Molecular targeting of gene therapy and radiotherapy. Acta Oncol. 2001; 40(6):735-8. PMID: 11765068.
      Citations: 12     Fields:    Translation:HumansCells
    149. Poon AP, Ogle WO, Roizman B. Posttranslational processing of infected cell protein 22 mediated by viral protein kinases is sensitive to amino acid substitutions at distant sites and can be cell-type specific. J Virol. 2000 Dec; 74(23):11210-4. PMID: 11070018; PMCID: PMC113214.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    150. Zhou G, Galvan V, Campadelli-Fiume G, Roizman B. Glycoprotein D or J delivered in trans blocks apoptosis in SK-N-SH cells induced by a herpes simplex virus 1 mutant lacking intact genes expressing both glycoproteins. J Virol. 2000 Dec; 74(24):11782-91. PMID: 11090178; PMCID: PMC112461.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    151. Zhou G, Roizman B. Wild-type herpes simplex virus 1 blocks programmed cell death and release of cytochrome c but not the translocation of mitochondrial apoptosis-inducing factor to the nuclei of human embryonic lung fibroblasts. J Virol. 2000 Oct; 74(19):9048-53. PMID: 10982349; PMCID: PMC102101.
      Citations: 13     Fields:    Translation:HumansCells
    152. Randall G, Lagunoff M, Roizman B. Herpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice. J Virol. 2000 Oct; 74(19):9019-27. PMID: 10982346; PMCID: PMC102098.
      Citations: 10     Fields:    Translation:AnimalsCells
    153. Advani SJ, Weichselbaum RR, Roizman B. The role of cdc2 in the expression of herpes simplex virus genes. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):10996-1001. PMID: 10995483; PMCID: PMC27137.
      Citations: 35     Fields:    Translation:HumansCells
    154. Ye GJ, Roizman B. The essential protein encoded by the UL31 gene of herpes simplex virus 1 depends for its stability on the presence of UL34 protein. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):11002-7. PMID: 11005871; PMCID: PMC27138.
      Citations: 46     Fields:    Translation:AnimalsCells
    155. Advani SJ, Weichselbaum RR, Roizman B. E2F proteins are posttranslationally modified concomitantly with a reduction in nuclear binding activity in cells infected with herpes simplex virus 1. J Virol. 2000 Sep; 74(17):7842-50. PMID: 10933691; PMCID: PMC112314.
      Citations: 16     Fields:    Translation:HumansCells
    156. Roizman B. Redefining virology. Science. 2000 Jun 30; 288(5475):2327-8. PMID: 10917831.
      Citations: 2     Fields:    Translation:HumansCells
    157. Ye GJ, Vaughan KT, Vallee RB, Roizman B. The herpes simplex virus 1 U(L)34 protein interacts with a cytoplasmic dynein intermediate chain and targets nuclear membrane. J Virol. 2000 Feb; 74(3):1355-63. PMID: 10627546; PMCID: PMC111470.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    158. Galvan V, Brandimarti R, Munger J, Roizman B. Bcl-2 blocks a caspase-dependent pathway of apoptosis activated by herpes simplex virus 1 infection in HEp-2 cells. J Virol. 2000 Feb; 74(4):1931-8. PMID: 10644366; PMCID: PMC111671.
      Citations: 28     Fields:    Translation:HumansCells
    159. Ward PL, Taddeo B, Markovitz NS, Roizman B. Identification of a novel expressed open reading frame situated between genes U(L)20 and U(L)21 of the herpes simplex virus 1 genome. Virology. 2000 Jan 20; 266(2):275-85. PMID: 10639314.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    160. Markert JM, Gillespie GY, Weichselbaum RR, Roizman B, Whitley RJ. Genetically engineered HSV in the treatment of glioma: a review. Rev Med Virol. 2000 Jan-Feb; 10(1):17-30. PMID: 10654002.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    161. Advani SJ, Brandimarti R, Weichselbaum RR, Roizman B. The disappearance of cyclins A and B and the increase in activity of the G(2)/M-phase cellular kinase cdc2 in herpes simplex virus 1-infected cells require expression of the alpha22/U(S)1.5 and U(L)13 viral genes. J Virol. 2000 Jan; 74(1):8-15. PMID: 10590085; PMCID: PMC111507.
      Citations: 53     Fields:    Translation:Cells
    162. Markovitz NS, Roizman B. Small dense nuclear bodies are the site of localization of herpes simplex virus 1 U(L)3 and U(L)4 proteins and of ICP22 only when the latter protein is present. J Virol. 2000 Jan; 74(1):523-8. PMID: 10590143; PMCID: PMC111565.
      Citations: 16     Fields:    Translation:AnimalsCells
    163. Markovitz NS, Roizman B. Replication-competent herpes simplex viral vectors for cancer therapy. Adv Virus Res. 2000; 55:409-24. PMID: 11050949.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
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