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Sampriti Mukherjee

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMolecular Genetics and Cell Biology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Our overarching goal is to understand how bacteria decode and integrate self-generated and environmentally-derived stimuli to control transitions between individual and collective behaviors. Bacterial responses to self-generated and exogenous stimuli influence their survival, persistence in particular niches, and lifestyle transitions, such as alterations between being free-swimming (individual behavior) or existing in structured antibiotic-resistant communities called biofilms (collective behavior). How the information encoded in multiple sensory inputs is extracted and integrated to drive transitions between individual and collective behaviors is largely mysterious. We use bacterial genetics, molecular biology, biochemistry, microfluidics, fluorescence microscopy, and genome-scale studies to study fundamental questions about bacterial signal detection, signal relay, signal integration, and the consequences to collective behaviors. Ultimately, understanding how information encoded in diverse sensory inputs drives collective behaviors will be foundational for designing successful synthetic strategies to enhance or to inhibit biofilms and for developing novel therapeutic interventions.
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    Collapse Biography 
    Collapse education and training
    Princeton University, Princeton, NJ , USAPostdoctoral Fellow08/2020Molecular Biology
    Indiana University, Bloomington, IN, USAPhD10/2014Microbiology
    University of Calcutta, Kolkata, IndiaBS07/2007Microbiology
    University of Calcutta, Kolkata, IndiaMS06/2009Microbiology
    Collapse awards and honors
    2022 - 2025Searle Scholars Program
    2018 - 2023NIH Pathway to Independence Award (K99/R00)
    2016 - 2019Life Sciences Research Foundation Postdoctoral Fellowship

    Collapse Research 
    Collapse research activities and funding
    R00GM129424     (MUKHERJEE, SAMPRITI)Sep 1, 2018 - Aug 31, 2023
    A New Quorum-Sensing Autoinducer Acts with the RhlR Receptor to Control Virulence and Biofilms in Pseudomonas Aeruginosa
    Role: Principal Investigator

    K99GM129424     (MUKHERJEE, SAMPRITI)Sep 1, 2018 - Aug 31, 2020
    A new quorum-sensing autoinducer acts with the RhlR receptor to control virulence and biofilms in Pseudomonas aeruginosa
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jiang Z, Nero T, Mukherjee S, Olson R, Yan J. Searching for the Secret of Stickiness: How Biofilms Adhere to Surfaces. Front Microbiol. 2021; 12:686793. PMID: 34305846; PMCID: PMC8295476.
      Citations: 11     
    2. van Kessel JC, Mukherjee S. Another battle won in the phage-host arms race: Pseudomonas phage blocks quorum sensing regulator LasR. Mol Cell. 2021 02 04; 81(3):420-422. PMID: 33545057.
      Citations: 1     Fields:    Translation:Cells
    3. Mukherjee S, Jemielita M, Stergioula V, Tikhonov M, Bassler BL. Photosensing and quorum sensing are integrated to control Pseudomonas aeruginosa collective behaviors. PLoS Biol. 2019 12; 17(12):e3000579. PMID: 31830037; PMCID: PMC6932827.
      Citations: 17     Fields:    Translation:Cells
    4. Mukherjee S, Bassler BL. Bacterial quorum sensing in complex and dynamically changing environments. Nat Rev Microbiol. 2019 06; 17(6):371-382. PMID: 30944413; PMCID: PMC6615036.
      Citations: 214     Fields:    
    5. Yan J, Moreau A, Khodaparast S, Perazzo A, Feng J, Fei C, Mao S, Mukherjee S, Ko?mrlj A, Wingreen NS, Bassler BL, Stone HA. Bacterial Biofilm Material Properties Enable Removal and Transfer by Capillary Peeling. Adv Mater. 2019 01; 31(4):e1807586. PMID: 30667139.
      Citations: 1     Fields:    
    6. Yan J, Moreau A, Khodaparast S, Perazzo A, Feng J, Fei C, Mao S, Mukherjee S, Ko?mrlj A, Wingreen NS, Bassler BL, Stone HA. Bacterial Biofilm Material Properties Enable Removal and Transfer by Capillary Peeling. Adv Mater. 2018 Nov; 30(46):e1804153. PMID: 30368924; PMCID: PMC8865467.
      Citations: 25     Fields:    Translation:HumansCellsPHPublic Health
    7. Mukherjee S, Moustafa DA, Stergioula V, Smith CD, Goldberg JB, Bassler BL. The PqsE and RhlR proteins are an autoinducer synthase-receptor pair that control virulence and biofilm development in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):E9411-E9418. PMID: 30224496; PMCID: PMC6176596.
      Citations: 49     Fields:    Translation:Cells
    8. Altegoer F, Mukherjee S, Steinchen W, Bedrunka P, Linne U, Kearns DB, Bange G. FliS/flagellin/FliW heterotrimer couples type III secretion and flagellin homeostasis. Sci Rep. 2018 08 01; 8(1):11552. PMID: 30068950; PMCID: PMC6070490.
      Citations: 11     Fields:    Translation:Cells
    9. Mukherjee S, Moustafa D, Smith CD, Goldberg JB, Bassler BL. The RhlR quorum-sensing receptor controls Pseudomonas aeruginosa pathogenesis and biofilm development independently of its canonical homoserine lactone autoinducer. PLoS Pathog. 2017 Jul; 13(7):e1006504. PMID: 28715477; PMCID: PMC5531660.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    10. Paczkowski JE, Mukherjee S, McCready AR, Cong JP, Aquino CJ, Kim H, Henke BR, Smith CD, Bassler BL. Flavonoids Suppress Pseudomonas aeruginosa Virulence through Allosteric Inhibition of Quorum-sensing Receptors. J Biol Chem. 2017 03 10; 292(10):4064-4076. PMID: 28119451; PMCID: PMC5354481.
      Citations: 60     Fields:    Translation:Cells
    11. H?yland-Kroghsbo NM, Paczkowski J, Mukherjee S, Broniewski J, Westra E, Bondy-Denomy J, Bassler BL. Quorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune system. Proc Natl Acad Sci U S A. 2017 01 03; 114(1):131-135. PMID: 27849583; PMCID: PMC5224376.
      Citations: 99     Fields:    Translation:Cells
    12. Mukherjee S, Oshiro RT, Yakhnin H, Babitzke P, Kearns DB. FliW antagonizes CsrA RNA binding by a noncompetitive allosteric mechanism. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9870-5. PMID: 27516547; PMCID: PMC5024615.
      Citations: 17     Fields:    Translation:Cells
    13. Abbott ZD, Flynn KJ, Byrne BG, Mukherjee S, Kearns DB, Swanson MS. csrT Represents a New Class of csrA-Like Regulatory Genes Associated with Integrative Conjugative Elements of Legionella pneumophila. J Bacteriol. 2016 02 01; 198(3):553-64. PMID: 26598366; PMCID: PMC4719454.
      Citations: 6     Fields:    Translation:AnimalsCells
    14. Mukherjee S, Bree AC, Liu J, Patrick JE, Chien P, Kearns DB. Adaptor-mediated Lon proteolysis restricts Bacillus subtilis hyperflagellation. Proc Natl Acad Sci U S A. 2015 Jan 06; 112(1):250-5. PMID: 25538299; PMCID: PMC4291670.
      Citations: 53     Fields:    Translation:Cells
    15. Mukherjee S, Kearns DB. The structure and regulation of flagella in Bacillus subtilis. Annu Rev Genet. 2014; 48:319-40. PMID: 25251856; PMCID: PMC4869327.
      Citations: 73     Fields:    Translation:Cells
    16. Snyder AJ, Mukherjee S, Glass JK, Kearns DB, Mukhopadhyay S. The canonical twin-arginine translocase components are not required for secretion of folded green fluorescent protein from the ancestral strain of Bacillus subtilis. Appl Environ Microbiol. 2014 May; 80(10):3219-32. PMID: 24632256; PMCID: PMC4018911.
      Citations: 2     Fields:    Translation:Cells
    17. Gao X, Mukherjee S, Matthews PM, Hammad LA, Kearns DB, Dann CE. Functional characterization of core components of the Bacillus subtilis cyclic-di-GMP signaling pathway. J Bacteriol. 2013 Nov; 195(21):4782-92. PMID: 23893111; PMCID: PMC3807487.
      Citations: 43     Fields:    Translation:Cells
    18. Mukherjee S, Babitzke P, Kearns DB. FliW and FliS function independently to control cytoplasmic flagellin levels in Bacillus subtilis. J Bacteriol. 2013 Jan; 195(2):297-306. PMID: 23144244; PMCID: PMC3553831.
      Citations: 36     Fields:    Translation:Cells
    19. Mukherjee S, Yakhnin H, Kysela D, Sokoloski J, Babitzke P, Kearns DB. CsrA-FliW interaction governs flagellin homeostasis and a checkpoint on flagellar morphogenesis in Bacillus subtilis. Mol Microbiol. 2011 Oct; 82(2):447-61. PMID: 21895793; PMCID: PMC3192257.
      Citations: 57     Fields:    Translation:Cells
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