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Sampriti Mukherjee

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMol Gen/Cell Bio
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    Our overarching goal is to understand how bacteria decode and integrate self-generated and environmentally-derived stimuli to control transitions between individual and collective behaviors. Bacterial responses to self-generated and exogenous stimuli influence their survival, persistence in particular niches, and lifestyle transitions, such as alterations between being free-swimming (individual behavior) or existing in structured antibiotic-resistant communities called biofilms (collective behavior). How the information encoded in multiple sensory inputs is extracted and integrated to drive transitions between individual and collective behaviors is largely mysterious. We use bacterial genetics, molecular biology, biochemistry, microfluidics, fluorescence microscopy, and genome-scale studies to study fundamental questions about bacterial signal detection, signal relay, signal integration, and the consequences to collective behaviors. Ultimately, understanding how information encoded in diverse sensory inputs drives collective behaviors will be foundational for designing successful synthetic strategies to enhance or to inhibit biofilms and for developing novel therapeutic interventions.


    Collapse Biography 
    Collapse education and training
    Princeton University, Princeton, NJ , USAPostdoctoral Fellow08/2020Molecular Biology
    Indiana University, Bloomington, IN, USAPhD10/2014Microbiology
    University of Calcutta, Kolkata, IndiaBS07/2007Microbiology
    University of Calcutta, Kolkata, IndiaMS06/2009Microbiology
    Collapse awards and honors
    2016 - 2019Life Sciences Research Foundation Postdoctoral Fellowship
    2018 - 2023NIH Pathway to Independence Award (K99/R00)

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Mukherjee S, Jemielita M, Stergioula V, Tikhonov M, Bassler BL. Photosensing and quorum sensing are integrated to control Pseudomonas aeruginosa collective behaviors. PLoS Biol. 2019 12; 17(12):e3000579. PMID: 31830037.
      View in: PubMed
    2. Mukherjee S, Bassler BL. Bacterial quorum sensing in complex and dynamically changing environments. Nat Rev Microbiol. 2019 06; 17(6):371-382. PMID: 30944413.
      View in: PubMed
    3. Yan J, Moreau A, Khodaparast S, Perazzo A, Feng J, Fei C, Mao S, Mukherjee S, Košmrlj A, Wingreen NS, Bassler BL, Stone HA. Bacterial Biofilm Material Properties Enable Removal and Transfer by Capillary Peeling. . 2019 01; 31(4):e1807586. PMID: 30667139.
      View in: PubMed
    4. Yan J, Moreau A, Khodaparast S, Perazzo A, Feng J, Fei C, Mao S, Mukherjee S, Košmrlj A, Wingreen NS, Bassler BL, Stone HA. Bacterial Biofilm Material Properties Enable Removal and Transfer by Capillary Peeling. . 2018 Nov; 30(46):e1804153. PMID: 30368924.
      View in: PubMed
    5. Mukherjee S, Moustafa DA, Stergioula V, Smith CD, Goldberg JB, Bassler BL. The PqsE and RhlR proteins are an autoinducer synthase-receptor pair that control virulence and biofilm development in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):E9411-E9418. PMID: 30224496.
      View in: PubMed
    6. Altegoer F, Mukherjee S, Steinchen W, Bedrunka P, Linne U, Kearns DB, Bange G. FliS/flagellin/FliW heterotrimer couples type III secretion and flagellin homeostasis. Sci Rep. 2018 08 01; 8(1):11552. PMID: 30068950.
      View in: PubMed
    7. Mukherjee S, Moustafa D, Smith CD, Goldberg JB, Bassler BL. The RhlR quorum-sensing receptor controls Pseudomonas aeruginosa pathogenesis and biofilm development independently of its canonical homoserine lactone autoinducer. PLoS Pathog. 2017 Jul; 13(7):e1006504. PMID: 28715477.
      View in: PubMed
    8. Paczkowski JE, Mukherjee S, McCready AR, Cong JP, Aquino CJ, Kim H, Henke BR, Smith CD, Bassler BL. Flavonoids Suppress Pseudomonas aeruginosa Virulence through Allosteric Inhibition of Quorum-sensing Receptors. J Biol Chem. 2017 03 10; 292(10):4064-4076. PMID: 28119451.
      View in: PubMed
    9. Høyland-Kroghsbo NM, Paczkowski J, Mukherjee S, Broniewski J, Westra E, Bondy-Denomy J, Bassler BL. Quorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune system. Proc Natl Acad Sci U S A. 2017 01 03; 114(1):131-135. PMID: 27849583.
      View in: PubMed
    10. Mukherjee S, Oshiro RT, Yakhnin H, Babitzke P, Kearns DB. FliW antagonizes CsrA RNA binding by a noncompetitive allosteric mechanism. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9870-5. PMID: 27516547.
      View in: PubMed
    11. Abbott ZD, Flynn KJ, Byrne BG, Mukherjee S, Kearns DB, Swanson MS. csrT Represents a New Class of csrA-Like Regulatory Genes Associated with Integrative Conjugative Elements of Legionella pneumophila. J Bacteriol. 2016 02 01; 198(3):553-64. PMID: 26598366.
      View in: PubMed
    12. Mukherjee S, Bree AC, Liu J, Patrick JE, Chien P, Kearns DB. Adaptor-mediated Lon proteolysis restricts Bacillus subtilis hyperflagellation. Proc Natl Acad Sci U S A. 2015 Jan 06; 112(1):250-5. PMID: 25538299.
      View in: PubMed
    13. Mukherjee S, Kearns DB. The structure and regulation of flagella in Bacillus subtilis. Annu Rev Genet. 2014; 48:319-40. PMID: 25251856.
      View in: PubMed
    14. Snyder AJ, Mukherjee S, Glass JK, Kearns DB, Mukhopadhyay S. The canonical twin-arginine translocase components are not required for secretion of folded green fluorescent protein from the ancestral strain of Bacillus subtilis. Appl Environ Microbiol. 2014 May; 80(10):3219-32. PMID: 24632256.
      View in: PubMed
    15. Gao X, Mukherjee S, Matthews PM, Hammad LA, Kearns DB, Dann CE. Functional characterization of core components of the Bacillus subtilis cyclic-di-GMP signaling pathway. J Bacteriol. 2013 Nov; 195(21):4782-92. PMID: 23893111.
      View in: PubMed
    16. Mukherjee S, Babitzke P, Kearns DB. FliW and FliS function independently to control cytoplasmic flagellin levels in Bacillus subtilis. J Bacteriol. 2013 Jan; 195(2):297-306. PMID: 23144244.
      View in: PubMed
    17. Mukherjee S, Yakhnin H, Kysela D, Sokoloski J, Babitzke P, Kearns DB. CsrA-FliW interaction governs flagellin homeostasis and a checkpoint on flagellar morphogenesis in Bacillus subtilis. Mol Microbiol. 2011 Oct; 82(2):447-61. PMID: 21895793.
      View in: PubMed
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