 Primary Ovarian Insufficiency
"Primary Ovarian Insufficiency" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections.
| Descriptor ID |
D016649
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| MeSH Number(s) |
C13.351.500.056.630.750 C19.391.630.750
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| Concept/Terms |
Primary Ovarian Insufficiency- Primary Ovarian Insufficiency
- Insufficiencies, Primary Ovarian
- Insufficiency, Primary Ovarian
- Ovarian Insufficiencies, Primary
- Ovarian Insufficiency, Primary
- Primary Ovarian Insufficiencies
- Premature Ovarian Failure
- Ovarian Failure, Premature
- Ovarian Failures, Premature
- Premature Ovarian Failures
Gonadotropin-Resistant Ovary Syndrome- Gonadotropin-Resistant Ovary Syndrome
- Gonadotropin Resistant Ovary Syndrome
- Gonadotropin-Resistant Ovary Syndromes
- Ovary Syndrome, Gonadotropin-Resistant
- Ovary Syndromes, Gonadotropin-Resistant
- Resistant Ovary Syndrome
- Ovary Syndrome, Resistant
- Ovary Syndromes, Resistant
- Resistant Ovary Syndromes
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Below are MeSH descriptors whose meaning is more general than "Primary Ovarian Insufficiency".
Below are MeSH descriptors whose meaning is more specific than "Primary Ovarian Insufficiency".
This graph shows the total number of publications written about "Primary Ovarian Insufficiency" by people in this website by year, and whether "Primary Ovarian Insufficiency" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 2 | 0 | 2 | | 2017 | 1 | 0 | 1 | | 2020 | 1 | 1 | 2 | | 2021 | 3 | 1 | 4 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Primary Ovarian Insufficiency" by people in Profiles.
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Maristany S, DuVall AS, Stock W, Adeleye AJ. Primary ovarian insufficiency secondary to chemotherapy with inotuzumab ozogamicin and other agents. J Assist Reprod Genet. 2022 Aug; 39(8):1733-1738.
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Ulin M, Cetin E, Hobeika E, Chugh RM, Park HS, Esfandyari S, Al-Hendy A. Human Mesenchymal Stem Cell Therapy and Other Novel Treatment Approaches for Premature Ovarian Insufficiency. Reprod Sci. 2021 06; 28(6):1688-1696.
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Park HS, Chugh RM, El Andaloussi A, Hobeika E, Esfandyari S, Elsharoud A, Ulin M, Garcia N, Bilal M, Al-Hendy A. Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model. Sci Rep. 2021 02 25; 11(1):4525.
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Esfandyari S, Elkafas H, Chugh RM, Park HS, Navarro A, Al-Hendy A. Exosomes as Biomarkers for Female Reproductive Diseases Diagnosis and Therapy. Int J Mol Sci. 2021 Feb 22; 22(4).
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Park HS, Chugh RM, Elsharoud A, Ulin M, Esfandyari S, Aboalsoud A, Bakir L, Al-Hendy A. Safety of Intraovarian Injection of Human Mesenchymal Stem Cells in a Premature Ovarian Insufficiency Mouse Model. Cell Transplant. 2021 Jan-Dec; 30:963689720988502.
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Esfandyari S, Chugh RM, Park HS, Hobeika E, Ulin M, Al-Hendy A. Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility. Cells. 2020 10 08; 9(10).
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Igboeli P, El Andaloussi A, Sheikh U, Takala H, ElSharoud A, McHugh A, Gavrilova-Jordan L, Levy S, Al-Hendy A. Intraovarian injection of autologous human mesenchymal stem cells increases estrogen production and reduces menopausal symptoms in women with premature ovarian failure: two case reports and a review of the literature. J Med Case Rep. 2020 Jul 18; 14(1):108.
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Mohamed SA, Shalaby SM, Abdelaziz M, Brakta S, Hill WD, Ismail N, Al-Hendy A. Human Mesenchymal Stem Cells Partially Reverse Infertility in Chemotherapy-Induced Ovarian Failure. Reprod Sci. 2018 01; 25(1):51-63.
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Ghadami M, El-Demerdash E, Zhang D, Salama SA, Binhazim AA, Archibong AE, Chen X, Ballard BR, Sairam MR, Al-Hendy A. Bone marrow transplantation restores follicular maturation and steroid hormones production in a mouse model for primary ovarian failure. PLoS One. 2012; 7(3):e32462.
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El-Khairi R, Parnaik R, Duncan AJ, Lin L, Gerrelli D, Dattani MT, Conway GS, Achermann JC. Analysis of LIN28A in early human ovary development and as a candidate gene for primary ovarian insufficiency. Mol Cell Endocrinol. 2012 Apr 04; 351(2):264-8.
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