Primary Ovarian Insufficiency
"Primary Ovarian Insufficiency" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections.
| Descriptor ID |
D016649
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| MeSH Number(s) |
C13.351.500.056.630.750 C19.391.630.750
|
| Concept/Terms |
Primary Ovarian Insufficiency- Primary Ovarian Insufficiency
- Insufficiency, Primary Ovarian
- Ovarian Insufficiency, Primary
- Premature Ovarian Failure
- Ovarian Failure, Premature
Hypergonadotropic Ovarian Failure, X-Linked- Hypergonadotropic Ovarian Failure, X-Linked
- Hypergonadotropic Ovarian Failure, X Linked
- FMR1-Related Primary Ovarian Insufficiency
- FMR1 Related Primary Ovarian Insufficiency
- Premature Ovarian Failure, X-Linked
- Premature Ovarian Failure, X Linked
- X-Linked Hypergonadotropic Ovarian Failure
- X Linked Hypergonadotropic Ovarian Failure
- Fragile X-Associated Primary Ovarian Insufficiency
- Fragile X Associated Primary Ovarian Insufficiency
- Premature Ovarian Failure 1
|
Below are MeSH descriptors whose meaning is more general than "Primary Ovarian Insufficiency".
Below are MeSH descriptors whose meaning is more specific than "Primary Ovarian Insufficiency".
This graph shows the total number of publications written about "Primary Ovarian Insufficiency" by people in this website by year, and whether "Primary Ovarian Insufficiency" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 1 | 3 |
| 2014 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 3 | 1 | 4 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 2 | 0 | 2 |
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Below are the most recent publications written about "Primary Ovarian Insufficiency" by people in Profiles.
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Homozygosity for a stop-gain variant in CCDC201 causes primary ovarian insufficiency. Nat Genet. 2024 Sep; 56(9):1804-1810.
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Fertility protection: a novel approach using pretreatment with mesenchymal stem cell exosomes to prevent chemotherapy-induced ovarian damage in a mouse model. Am J Obstet Gynecol. 2024 07; 231(1):111.e1-111.e18.
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Comparison of the therapeutic effects between stem cells and exosomes in primary ovarian insufficiency: as promising as cells but different persistency and dosage. Stem Cell Res Ther. 2023 06 20; 14(1):165.
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Primary ovarian insufficiency secondary to chemotherapy with inotuzumab ozogamicin and other agents. J Assist Reprod Genet. 2022 Aug; 39(8):1733-1738.
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Human Mesenchymal Stem Cell Therapy and Other Novel Treatment Approaches for Premature Ovarian Insufficiency. Reprod Sci. 2021 06; 28(6):1688-1696.
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Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model. Sci Rep. 2021 02 25; 11(1):4525.
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Exosomes as Biomarkers for Female Reproductive Diseases Diagnosis and Therapy. Int J Mol Sci. 2021 Feb 22; 22(4).
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Safety of Intraovarian Injection of Human Mesenchymal Stem Cells in a Premature Ovarian Insufficiency Mouse Model. Cell Transplant. 2021 Jan-Dec; 30:963689720988502.
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Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility. Cells. 2020 10 08; 9(10).
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Intraovarian injection of autologous human mesenchymal stem cells increases estrogen production and reduces menopausal symptoms in women with premature ovarian failure: two case reports and a review of the literature. J Med Case Rep. 2020 Jul 18; 14(1):108.