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Jessica J. Kandel

InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Collapse Overview 

    Collapse Biography 
    Collapse education and training
    Yale University, New Haven, CTBA05/1981Medieval Studies
    Columbia University, New York, NYMD5/1985Medicine
    Massachusetts General Hospital, Boston, MA06/1989Surgical residency (PGY 1-3)
    Boston Children's Hospital, Boston, MA06/1991Surgical research
    Massachusetts General Hospital, Boston, MA06/1993Surgical residency (PGY 4-5)
    Johns Hopkins Hospital, Baltimore, MD06/1995Pediatric Surgery Fellowship
    Collapse awards and honors
    1977Presidential Scholar, United States Presidential Scholars Program
    1981Phi Beta Kappa, Yale University
    1985NIH Training Grant, National Institutes of Health
    1985Upjohn Award for Excellence in Research, Columbia University
    1989 - 1991Marshal K. Bartlett Fellowship Award, Massachusetts General Hospital
    1999Peter Paul Rickham Prize, British Association of Paediatric Surgeons
    2001Irving Scholar Award, Columbia University
    2002Kyushu University Visiting Professorship, Kyushu University, Japan
    2003Doctor Harold and Golden Lamport Award for Excellence in Basic Science Research, Columbia University
    2003Schullinger Lectureship in Pediatric Cancer, Columbia University
    2004Institute for Cancer Genetics, Associate Professorship, Columbia University
    2008Elected, American Surgical Association
    2009R. Peter Altman Chair in Surgery, Columbia University
    2013Mary Campau Ryerson Chair in Surgery, University of Chicago
    2013Master Clinician, Bucksbaum Institute for Clinical Excellence, University of Chicago
    2014 - 2019Faculty Teaching Award, Department of Surgery, University of Chicago

    Collapse Research 
    Collapse research activities and funding
         (Jessica Kandel)Jul 1, 1997 - Dec 31, 2022
    Pediatric Cancer Foundation
    Studies in pediatric tumor angiogenesis
    Role Description: Our goal is to understand the role that abnormal functions and development of vasculature play in promoting tumor growth and metastasis.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kandel JJ. Mentorship: Finding a Way Forward in Pediatric Surgery. J Pediatr Surg. 2024 Jan; 59(1):1-5. PMID: 37833212.
      Citations:    Fields:    Translation:Humans
    2. Bellary A, Nowak C, Iwanicki I, Flores-Guzman F, Wu L, Kandel JJ, Laetsch TW, Bleris L, Hernandez SL, Sirsi SR. Non-viral nitric oxide-based gene therapy improves perfusion and liposomal doxorubicin sonopermeation in neuroblastoma models. Theranostics. 2023; 13(10):3402-3418. PMID: 37351172; PMCID: PMC10283050.
      Citations:    Fields:    Translation:HumansCells
    3. Iwanicki I, Wu LL, Flores-Guzman F, Sundland R, Viza-Gomes P, Nordgren R, Centner CS, Kandel JJ, Applebaum MA, Bader KB, Hernandez SL. Histotripsy induces apoptosis and reduces hypoxia in a neuroblastoma xenograft model. Int J Hyperthermia. 2023; 40(1):2222941. PMID: 37344380.
      Citations: 1     Fields:    Translation:HumansAnimals
    4. Slater BJ, Collings AT, Corvin C, Kandel JJ. Value-based surgery physician compensation model: Review of the literature. J Pediatr Surg. 2022 Sep; 57(9):118-123. PMID: 35093253.
      Citations: 2     Fields:    Translation:Humans
    5. Slidell MB, Kandel JJ, Prachand V, Matthews JB, Mak GZ. Pediatric Medically Necessary, Time-Sensitive Scoring Tool Facilitates Dynamic and Flexible Decision-Making and Triage for Procedures: In Reply to González Villarreal and Colleagues. J Am Coll Surg. 2021 02; 232(2):226. PMID: 33162323.
      Citations:    Fields:    Translation:HumansCells
    6. Bellary A, Villarreal A, Eslami R, Undseth QJ, Lec B, Defnet AM, Bagrodia N, Kandel JJ, Borden MA, Shaikh S, Chopra R, Laetsch TW, Delaney LJ, Shaw CM, Eisenbrey JR, Hernandez SL, Sirsi SR. Perfusion-guided sonopermeation of neuroblastoma: a novel strategy for monitoring and predicting liposomal doxorubicin uptake in vivo. Theranostics. 2020; 10(18):8143-8161. PMID: 32724463; PMCID: PMC7381728.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    7. Wieck MM, Kandel JJ, Mak GZ. Fighting the Moral Distress of Idleness. J Surg Res. 2020 10; 254:348-349. PMID: 32526504; PMCID: PMC7276304.
      Citations:    Fields:    Translation:Humans
    8. Slidell MB, Kandel JJ, Prachand V, Baroody FM, Gundeti MS, Reid RR, Angelos P, Matthews JB, Mak GZ. Pediatric Modification of the Medically Necessary, Time-Sensitive Scoring System for Operating Room Procedure Prioritization During the COVID-19 Pandemic. J Am Coll Surg. 2020 08; 231(2):205-215. PMID: 32473197; PMCID: PMC7251404.
      Citations: 7     Fields:    Translation:HumansCellsPHPublic Health
    9. Mak GZ, Kandel JJ. Editorial: Changing paradigms in pediatric surgery. Curr Opin Pediatr. 2019 06; 31(3):367. PMID: 31090578.
      Citations:    Fields:    Translation:Humans
    10. Hernandez SL, Nelson M, Sampedro GR, Bagrodia N, Defnet AM, Lec B, Emolo J, Kirschner R, Wu L, Biermann H, Shen S, Bubeck Wardenburg J, Kandel JJ. Staphylococcus aureus alpha toxin activates Notch in vascular cells. Angiogenesis. 2019 02; 22(1):197-209. PMID: 30324336; PMCID: PMC6360126.
      Citations: 9     Fields:    Translation:HumansCells
    11. Linden AF, Raiji MT, Kohler JE, Carlisle EM, Pelayo JC, Feinstein K, Kandel JJ, Mak GZ. Evaluation of a water-soluble contrast protocol for nonoperative management of pediatric adhesive small bowel obstruction. J Pediatr Surg. 2019 Jan; 54(1):184-188. PMID: 30414689.
      Citations: 2     Fields:    Translation:Humans
    12. Boboila S, Lopez G, Yu J, Banerjee D, Kadenhe-Chiweshe A, Connolly EP, Kandel JJ, Rajbhandari P, Silva JM, Califano A, Yamashiro DJ. Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma. Oncogene. 2018 10; 37(40):5451-5465. PMID: 29880876; PMCID: PMC6172192.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    13. Shakhsheer BA, Lec B, Zaborin A, Guyton K, Defnet AM, Bagrodia N, Kandel JJ, Zaborina O, Hernandez SL, Alverdy J. Lack of evidence for tissue hypoxia as a contributing factor in anastomotic leak following colon anastomosis and segmental devascularization in rats. Int J Colorectal Dis. 2017 Apr; 32(4):539-547. PMID: 27999936.
      Citations: 9     Fields:    Translation:Animals
    14. Wu JK, Hooper ED, Laifer-Narin SL, Simpson LL, Kandel J, Shawber CJ, Lymphatics Work Group at CUMC. Initial Experience With Propranolol Treatment of Lymphatic Anomalies: A Case Series. Pediatrics. 2016 09; 138(3). PMID: 27561730; PMCID: PMC5005016.
      Citations: 7     Fields:    Translation:Humans
    15. Ehrlich PF, Hamilton TE, Gow K, Barnhart D, Ferrer F, Kandel J, Glick R, Dasgupta R, Naranjo A, He Y, Perlman EJ, Kalapurakal JA, Khanna G, Dome JS, Geller J, Mullen E. Surgical protocol violations in children with renal tumors provides an opportunity to improve pediatric cancer care: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2016 11; 63(11):1905-10. PMID: 27229358; PMCID: PMC5030129.
      Citations: 10     Fields:    Translation:Humans
    16. Defnet AM, Bagrodia N, Hernandez SL, Gwilliam N, Kandel JJ. Pediatric lymphatic malformations: evolving understanding and therapeutic options. Pediatr Surg Int. 2016 May; 32(5):425-33. PMID: 26815877.
      Citations: 20     Fields:    Translation:Humans
    17. Geyer MB, Radhakrishnan K, Giller R, Umegaki N, Harel S, Kiuru M, Morel KD, LeBoeuf N, Kandel J, Bruckner A, Fabricatore S, Chen M, Woodley D, McGrath J, Baxter-Lowe L, Uitto J, Christiano AM, Cairo MS. Reduced Toxicity Conditioning and Allogeneic Hematopoietic Progenitor Cell Transplantation for Recessive Dystrophic Epidermolysis Bullosa. J Pediatr. 2015 Sep; 167(3):765-9.e1. PMID: 26148662.
      Citations: 13     Fields:    Translation:HumansCells
    18. Bagrodia N, Defnet AM, Kandel JJ. Management of lymphatic malformations in children. Curr Opin Pediatr. 2015 Jun; 27(3):356-63. PMID: 25888145.
      Citations: 30     Fields:    Translation:Humans
    19. Nolan TL, Kandel JJ, Nakayama DK. Quality and extent of locum tenens coverage in pediatric surgical practices. Am Surg. 2015 Apr; 81(4):377-80. PMID: 25831184.
      Citations: 2     Fields:    Translation:Humans
    20. Banerjee D, Hernandez SL, Garcia A, Kangsamaksin T, Sbiroli E, Andrews J, Forrester LA, Wei N, Kadenhe-Chiweshe A, Shawber CJ, Kitajewski JK, Kandel JJ, Yamashiro DJ. Notch suppresses angiogenesis and progression of hepatic metastases. Cancer Res. 2015 Apr 15; 75(8):1592-602. PMID: 25744722; PMCID: PMC4401639.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    21. Wu JK, Kitajewski C, Reiley M, Keung CH, Monteagudo J, Andrews JP, Liou P, Thirumoorthi A, Wong A, Kandel JJ, Shawber CJ. Aberrant lymphatic endothelial progenitors in lymphatic malformation development. PLoS One. 2015; 10(2):e0117352. PMID: 25719418; PMCID: PMC4342011.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    22. Rothstein DH, Kandel JJ. Pediatric surgical transitional care. Preface. Semin Pediatr Surg. 2015 Apr; 24(2):59-60. PMID: 25770363.
      Citations:    Fields:    Translation:Humans
    23. Weitz NA, Lauren CT, Behr GG, Wu JK, Kandel JJ, Meyers PM, Sultan S, Anyane-Yeboa K, Morel KD, Garzon MC. Clinical spectrum of capillary malformation-arteriovenous malformation syndrome presenting to a pediatric dermatology practice: a retrospective study. Pediatr Dermatol. 2015 Jan-Feb; 32(1):76-84. PMID: 25040287.
      Citations: 5     Fields:    Translation:Humans
    24. Aspelund G, Fingeret A, Gross E, Kessler D, Keung C, Thirumoorthi A, Oh PS, Behr G, Chen S, Lampl B, Middlesworth W, Kandel J, Ruzal-Shapiro C. Ultrasonography/MRI versus CT for diagnosing appendicitis. Pediatrics. 2014 Apr; 133(4):586-93. PMID: 24590746.
      Citations: 37     Fields:    Translation:Humans
    25. Kandel JJ. Serendipity: translational research, high quality care, and the children's hospital. Jay and Margie Grosfeld Lecture. J Pediatr Surg. 2014 Jan; 49(1):19-24. PMID: 24439574.
      Citations:    Fields:    Translation:Humans
    26. Hamilton TE, Barnhart D, Gow K, Ferrer F, Kandel J, Glick R, Dasgupta R, Naranjo A, He Y, Gratias E, Geller J, Mullen E, Ehrlich P. Inter-rater reliability of surgical reviews for AREN03B2: a COG renal tumor committee study. J Pediatr Surg. 2014 Jan; 49(1):154-8; discussion 158. PMID: 24439601; PMCID: PMC4076163.
      Citations: 3     Fields:    Translation:Humans
    27. Hernandez SL, Banerjee D, Garcia A, Kangsamaksin T, Cheng WY, Anastassiou D, Funahashi Y, Kadenhe-Chiweshe A, Shawber CJ, Kitajewski JK, Kandel JJ, Yamashiro DJ. Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesis. Vasc Cell. 2013 Sep 25; 5(1):17. PMID: 24066611; PMCID: PMC3849070.
      Citations: 20     
    28. Liou P, Bader L, Wang A, Yamashiro D, Kandel JJ. Correlation of tumor-associated macrophages and clinicopathological factors in Wilms tumor. Vasc Cell. 2013 Mar 21; 5(1):5. PMID: 23514200; PMCID: PMC3610208.
      Citations: 9     
    29. Gow KW, Barnhart DC, Hamilton TE, Kandel JJ, Chen MK, Ferrer FA, Price MR, Mullen EA, Geller JI, Gratias EJ, Rosen N, Khanna G, Naranjo A, Ritchey ML, Grundy PE, Dome JS, Ehrlich PF. Primary nephrectomy and intraoperative tumor spill: report from the Children's Oncology Group (COG) renal tumors committee. J Pediatr Surg. 2013 Jan; 48(1):34-8. PMID: 23331790; PMCID: PMC4556229.
      Citations: 19     Fields:    Translation:HumansCTClinical Trials
    30. Uh MK, Kandel J, Kitajewski J. Evaluating tumor angiogenesis. Methods Mol Biol. 2013; 980:341-51. PMID: 23359165.
      Citations: 2     Fields:    Translation:HumansAnimals
    31. Behr GG, Liberman L, Compton J, Garzon MC, Morel KD, Lauren CT, Starc TJ, Kovacs SJ, Beltroni V, Landres R, Anyane-Yeboa K, Meyers PM, Bacha E, Kandel JJ. CM-AVM syndrome in a neonate: case report and treatment with a novel flow reduction strategy. Vasc Cell. 2012 Nov 20; 4(1):19. PMID: 23164092; PMCID: PMC3517480.
      Citations: 2     
    32. Weitz NA, Lauren CT, Starc TJ, Kandel JJ, Bateman DA, Morel KD, Meyers PM, Kadenhe-Chiweshe A, Wu JK, Garzon MC. Congenital cutaneous hemangioma causing cardiac failure: a case report and review of the literature. Pediatr Dermatol. 2013 Nov-Dec; 30(6):e180-90. PMID: 23025620.
      Citations: 9     Fields:    Translation:Humans
    33. Garcia AV, Thirumoorthi AS, Traina JM, Schlossberg P, Sheynzon V, Kandel JJ. Image-guided esophageal anastomosis in esophageal atresia. J Pediatr Surg. 2012 Oct; 47(10):1959-61. PMID: 23084217.
      Citations:    Fields:    Translation:Humans
    34. Cheng WY, Kandel JJ, Yamashiro DJ, Canoll P, Anastassiou D. A multi-cancer mesenchymal transition gene expression signature is associated with prolonged time to recurrence in glioblastoma. PLoS One. 2012; 7(4):e34705. PMID: 22493711; PMCID: PMC3321034.
      Citations: 70     Fields:    Translation:HumansCells
    35. Garcia AV, Fingeret AL, Thirumoorthi AS, Kadenhe-Chiweshe A, Kandel JJ. Severe Mycoplasma pneumoniae infection requiring extracorporeal membrane oxygenation with concomitant ischemic stroke in a child. Pediatr Pulmonol. 2013 Jan; 48(1):98-101. PMID: 22467515.
      Citations: 12     Fields:    Translation:Humans
    36. Sirsi SR, Flexman ML, Vlachos F, Huang J, Hernandez SL, Kim HK, Johung TB, Gander JW, Reichstein AR, Lampl BS, Wang A, Hielscher AH, Kandel JJ, Yamashiro DJ, Borden MA. Contrast ultrasound imaging for identification of early responder tumor models to anti-angiogenic therapy. Ultrasound Med Biol. 2012 Jun; 38(6):1019-29. PMID: 22425376; PMCID: PMC3348332.
      Citations: 31     Fields:    Translation:Animals
    37. Garcia A, Kandel JJ. Notch: a key regulator of tumor angiogenesis and metastasis. Histol Histopathol. 2012 02; 27(2):151-6. PMID: 22207549; PMCID: PMC3272301.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    38. Flexman ML, Vlachos F, Kim HK, Sirsi SR, Huang J, Hernandez SL, Johung TB, Gander JW, Reichstein AR, Lampl BS, Wang A, Borden MA, Yamashiro DJ, Kandel JJ, Hielscher AH. Monitoring early tumor response to drug therapy with diffuse optical tomography. J Biomed Opt. 2012 Jan; 17(1):016014. PMID: 22352664; PMCID: PMC3380816.
      Citations: 9     Fields:    Translation:Animals
    39. Anastassiou D, Rumjantseva V, Cheng W, Huang J, Canoll PD, Yamashiro DJ, Kandel JJ. Human cancer cells express Slug-based epithelial-mesenchymal transition gene expression signature obtained in vivo. BMC Cancer. 2011 Dec 30; 11:529. PMID: 22208948; PMCID: PMC3268117.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    40. Fisher JC, Gander JW, Haley MJ, Hernandez SL, Huang J, Chang YJ, Johung TB, Guarnieri P, O'Toole K, Yamashiro DJ, Kandel JJ. Inhibition of cyclo-oxygenase 2 reduces tumor metastasis and inflammatory signaling during blockade of vascular endothelial growth factor. Vasc Cell. 2011 Oct 06; 3:22. PMID: 21978392; PMCID: PMC3198683.
      Citations: 2     
    41. Sirsi SR, Hernandez SL, Zielinski L, Blomback H, Koubaa A, Synder M, Homma S, Kandel JJ, Yamashiro DJ, Borden MA. Polyplex-microbubble hybrids for ultrasound-guided plasmid DNA delivery to solid tumors. J Control Release. 2012 Jan 30; 157(2):224-34. PMID: 21945680; PMCID: PMC3822338.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    42. Oe Y, Orr L, Laifer-Narin S, Hyodo E, Koczo A, Homma S, Kandel J, Meyers P. Contrast-enhanced sonography as a novel tool for assessment of vascular malformations. J Angiogenes Res. 2010 Nov 22; 2:25. PMID: 21092206; PMCID: PMC3002313.
      Citations: 3     
    43. Kim HK, Flexman M, Yamashiro DJ, Kandel JJ, Hielscher AH. PDE-constrained multispectral imaging of tissue chromophores with the equation of radiative transfer. Biomed Opt Express. 2010 Sep 08; 1(3):812-824. PMID: 21258511; PMCID: PMC3018054.
      Citations: 13     
    44. Boo YJ, Fisher JC, Haley MJ, Cowles RA, Kandel JJ, Yamashiro DJ. Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review. J Pediatr Surg. 2009 Oct; 44(10):2031-6. PMID: 19853769.
      Citations: 10     Fields:    Translation:Humans
    45. Wan P, Susman J, Kandel J, Jan D, Jerome EH, Parravicini E. Neonatal hepatic mesenchymal hamartoma causing cardiac failure and disseminated intravascular coagulopathy. Am J Perinatol. 2009 Sep; 26(8):601-4. PMID: 19370509.
      Citations: 1     Fields:    Translation:Humans
    46. Zaghloul N, Hernandez SL, Bae JO, Huang J, Fisher JC, Lee A, Kadenhe-Chiweshe A, Kandel JJ, Yamashiro DJ. Vascular endothelial growth factor blockade rapidly elicits alternative proangiogenic pathways in neuroblastoma. Int J Oncol. 2009 Feb; 34(2):401-7. PMID: 19148474; PMCID: PMC3070359.
      Citations: 15     Fields:    Translation:HumansAnimals
    47. Huang J, Bae JO, Tsai JP, Kadenhe-Chiweshe A, Papa J, Lee A, Zeng S, Kornfeld ZN, Ullner P, Zaghloul N, Ioffe E, Nandor S, Burova E, Holash J, Thurston G, Rudge J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade. Int J Oncol. 2009 Jan; 34(1):79-87. PMID: 19082480; PMCID: PMC3160826.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    48. Funahashi Y, Hernandez SL, Das I, Ahn A, Huang J, Vorontchikhina M, Sharma A, Kanamaru E, Borisenko V, Desilva DM, Suzuki A, Wang X, Shawber CJ, Kandel JJ, Yamashiro DJ, Kitajewski J. A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis. Cancer Res. 2008 Jun 15; 68(12):4727-35. PMID: 18559519; PMCID: PMC3690602.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    49. Glade Bender JL, Adamson PC, Reid JM, Xu L, Baruchel S, Shaked Y, Kerbel RS, Cooney-Qualter EM, Stempak D, Chen HX, Nelson MD, Krailo MD, Ingle AM, Blaney SM, Kandel JJ, Yamashiro DJ, Children's Oncology Group Study. Phase I trial and pharmacokinetic study of bevacizumab in pediatric patients with refractory solid tumors: a Children's Oncology Group Study. J Clin Oncol. 2008 Jan 20; 26(3):399-405. PMID: 18202416.
      Citations: 99     Fields:    Translation:HumansCTClinical Trials
    50. Kadenhe-Chiweshe A, Papa J, McCrudden KW, Frischer J, Bae JO, Huang J, Fisher J, Lefkowitch JH, Feirt N, Rudge J, Holash J, Yancopoulos GD, Kandel JJ, Yamashiro DJ. Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation. Mol Cancer Res. 2008 Jan; 6(1):1-9. PMID: 18234958.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    51. Cowles RA, Gewanter RM, Kandel JJ. Ovarian repositioning in pediatric cancer patients: Flexible techniques accommodate pelvic radiation fields. Pediatr Blood Cancer. 2007 Sep; 49(3):339-41. PMID: 16261563.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    52. Nord KM, Kandel J, Lefkowitch JH, Lobritto SJ, Morel KD, North PE, Garzon MC. Multiple cutaneous infantile hemangiomas associated with hepatic angiosarcoma: case report and review of the literature. Pediatrics. 2006 Sep; 118(3):e907-13. PMID: 16880251.
      Citations: 11     Fields:    Translation:Humans
    53. Lee A, Frischer J, Serur A, Huang J, Bae JO, Kornfield ZN, Eljuga L, Shawber CJ, Feirt N, Mansukhani M, Stempak D, Baruchel S, Glade Bender J, Kandel JJ, Yamashiro DJ. Inhibition of cyclooxygenase-2 disrupts tumor vascular mural cell recruitment and survival signaling. Cancer Res. 2006 Apr 15; 66(8):4378-84. PMID: 16618763.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    54. Cowles RA, Stolar CJ, Kandel JJ, Weintraub JL, Susman J, Spigland NA. Preoperative angiography with embolization and radiofrequency ablation as novel adjuncts to safe surgical resection of a large, vascular sacrococcygeal teratoma. Pediatr Surg Int. 2006 Jun; 22(6):554-6. PMID: 16479404.
      Citations: 5     Fields:    Translation:Humans
    55. Yuan E, Li CM, Yamashiro DJ, Kandel J, Thaker H, Murty VV, Tycko B. Genomic profiling maps loss of heterozygosity and defines the timing and stage dependence of epigenetic and genetic events in Wilms' tumors. Mol Cancer Res. 2005 Sep; 3(9):493-502. PMID: 16179496.
      Citations: 18     Fields:    Translation:HumansCells
    56. Masciotti J, Abdoulaev G, Provenzano F, Hur J, Papa J, Bae J, Huang J, Yamashiro D, Kandel J, Hielscher A. Optical Tomographic and Magnetic Resonance Imaging of Tumor Growth and Regression in Mice treated with VEGF Blockade. Conf Proc IEEE Eng Med Biol Soc. 2005; 2006:205-8. PMID: 17282148.
      Citations:    Fields:    
    57. Frischer JS, Huang J, Serur A, Kadenhe-Chiweshe A, McCrudden KW, O'Toole K, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature. Int J Oncol. 2004 Sep; 25(3):549-53. PMID: 15289855.
      Citations: 13     Fields:    Translation:AnimalsCells
    58. Glade Bender J, Cooney EM, Kandel JJ, Yamashiro DJ. Vascular remodeling and clinical resistance to antiangiogenic cancer therapy. Drug Resist Updat. 2004 Aug-Oct; 7(4-5):289-300. PMID: 15533766.
      Citations: 28     Fields:    Translation:HumansAnimals
    59. Frischer JS, Huang J, Serur A, Kadenhe A, Yamashiro DJ, Kandel JJ. Biomolecular markers and involution of hemangiomas. J Pediatr Surg. 2004 Mar; 39(3):400-4. PMID: 15017560.
      Citations: 12     Fields:    Translation:Humans
    60. Huang J, Frischer JS, New T, Kim ES, Serur A, Lee A, Kadenhe-Chiwishe A, Pollyea DA, Yokoi A, Holash J, Yancopoulos GD, Kandel JJ, Yamashiro DJ. TNP-470 promotes initial vascular sprouting in xenograft tumors. Mol Cancer Ther. 2004 Mar; 3(3):335-43. PMID: 15026554.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    61. Davidoff AM, Kandel JJ. Antiangiogenic therapy for the treatment of pediatric solid malignancies. Semin Pediatr Surg. 2004 Feb; 13(1):53-60. PMID: 14765371.
      Citations: 2     Fields:    Translation:HumansAnimals
    62. Huang J, Soffer SZ, Kim ES, McCrudden KW, Huang J, New T, Manley CA, Middlesworth W, O'Toole K, Yamashiro DJ, Kandel JJ. Vascular remodeling marks tumors that recur during chronic suppression of angiogenesis. Mol Cancer Res. 2004 Jan; 2(1):36-42. PMID: 14757844.
      Citations: 44     Fields:    Translation:HumansAnimals
    63. Kaicker S, McCrudden KW, Beck L, New T, Huang J, Frischer JS, Serur A, Kadenhe-Chiweshe A, Yokoi A, Kandel JJ, Yamashiro DJ. Thalidomide is anti-angiogenic in a xenograft model of neuroblastoma. Int J Oncol. 2003 Dec; 23(6):1651-5. PMID: 14612937.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    64. Yokoi A, McCrudden KW, Huang J, Kim ES, Soffer SZ, Frischer JS, Serur A, New T, Yuan J, Mansukhani M, O'toole K, Yamashiro DJ, Kandel JJ. Human epidermal growth factor receptor signaling contributes to tumor growth via angiogenesis in her2/neu-expressing experimental Wilms' tumor. J Pediatr Surg. 2003 Nov; 38(11):1569-73. PMID: 14614702.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    65. Yokoi A, McCrudden KW, Huang J, Kim ES, Soffer SZ, Frischer JS, Serur A, New T, Yuan J, Mansukhani M, O'Toole K, Yamashiro DJ, Kandel JJ. Blockade of her2/neu decreases VEGF expression but does not alter HIF-1 distribution in experimental Wilms tumor. Oncol Rep. 2003 Sep-Oct; 10(5):1271-4. PMID: 12883692.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    66. Huang J, Frischer JS, Serur A, Kadenhe A, Yokoi A, McCrudden KW, New T, O'Toole K, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Regression of established tumors and metastases by potent vascular endothelial growth factor blockade. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7785-90. PMID: 12805568; PMCID: PMC164665.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    67. Glade-Bender J, Kandel JJ, Yamashiro DJ. VEGF blocking therapy in the treatment of cancer. Expert Opin Biol Ther. 2003 Apr; 3(2):263-76. PMID: 12662141.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    68. McCrudden KW, Hopkins B, Frischer J, Novikov A, Huang J, Kadenhe A, New T, Yokoi A, Yamashiro DJ, Kandel JJ, Middlesworth W. Anti-VEGF antibody in experimental hepatoblastoma: suppression of tumor growth and altered angiogenesis. J Pediatr Surg. 2003 Mar; 38(3):308-14; discussion 308-14. PMID: 12632340.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    69. Kim ES, Serur A, Huang J, Manley CA, McCrudden KW, Frischer JS, Soffer SZ, Ring L, New T, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Kandel JJ, Yamashiro DJ, Kim ES, Serur A, Huang J, Manley CA, McCrudden KW, Frischer JS, Soffer SZ, Ring L, New T, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Kandel JJ, Yamashiro DJ. Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):11399-404. PMID: 12177446; PMCID: PMC123268.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    70. McCrudden KW, Yokoi A, Thosani A, Soffer SZ, Kim ES, Huang J, Manley C, O'toole K, Yamashiro DJ, Kandel JJ, Middlesworth W. Topotecan is anti-angiogenic in experimental hepatoblastoma. J Pediatr Surg. 2002 Jun; 37(6):857-61. PMID: 12037749.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    71. Soffer SZ, Kim E, Huang J, McCrudden K, Yokoi A, Moore JT, Manley C, O'Toole K, Middlesworth W, Stolar C, Yamashiro DJ, Kandel JJ. Resistance of a VEGF-producing tumor to anti-VEGF antibody: unimpeded growth of human rhabdoid tumor xenografts. J Pediatr Surg. 2002 Mar; 37(3):528-32. PMID: 11877682.
      Citations: 1     Fields:    Translation:HumansAnimals
    72. Huang J, Soffer SZ, Kim ES, Yokoi A, Moore JT, McCrudden KW, Manley C, Middlesworth W, O'Toole K, Stolar C, Yamashiro DJ, Kandel JJ. p53 accumulation in favorable-histology Wilms tumor is associated with angiogenesis and clinically aggressive disease. J Pediatr Surg. 2002 Mar; 37(3):523-7. PMID: 11877681.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    73. Kim ES, Soffer SZ, Huang J, McCrudden KW, Yokoi A, Manley CA, Middlesworth W, Kandel JJ, Yamashiro DJ. Distinct response of experimental neuroblastoma to combination antiangiogenic strategies. J Pediatr Surg. 2002 Mar; 37(3):518-22. PMID: 11877680.
      Citations: 6     Fields:    Translation:AnimalsCells
    74. Soffer SZ, Kim E, Moore JT, Huang J, Yokoi A, Manley C, O'Toole K, Middlesworth W, Stolar C, Yamashiro D, Kandel J. Novel use of an established agent: Topotecan is anti-angiogenic in experimental Wilms tumor. J Pediatr Surg. 2001 Dec; 36(12):1781-4. PMID: 11733906.
      Citations: 6     Fields:    Translation:Animals
    75. Soffer SZ, Moore JT, Kim E, Huang J, Yokoi A, Manley C, O'Toole K, Stolar C, Middlesworth W, Yamashiro DJ, Kandel JJ, Soffer SZ, Moore JT, Kim E, Huang J, Yokoi A, Manley C, O'Toole K, Stolar C, Middlesworth W, Yamashiro DJ, Kandel JJ. Combination antiangiogenic therapy: increased efficacy in a murine model of Wilms tumor. J Pediatr Surg. 2001 Aug; 36(8):1177-81. PMID: 11479851.
      Citations: 8     Fields:    Translation:Animals
    76. Moore J, Lee M, Garzon M, Soffer S, Kim E, Saouaf R, del Toro G, Yamashiro D, Kandel J, Moore J, Lee M, Garzon M, Soffer S, Kim E, Saouaf R, del Toro G, Yamashiro D, Kandel J. Effective therapy of a vascular tumor of infancy with vincristine. J Pediatr Surg. 2001 Aug; 36(8):1273-6. PMID: 11479875.
      Citations: 4     Fields:    Translation:Humans
    77. Huang J, Moore J, Soffer S, Kim E, Rowe D, Manley CA, O'Toole K, Middlesworth W, Stolar C, Yamashiro D, Kandel J. Highly specific antiangiogenic therapy is effective in suppressing growth of experimental Wilms tumors. J Pediatr Surg. 2001 Feb; 36(2):357-61. PMID: 11172434.
      Citations: 11     Fields:    Translation:AnimalsCells
    78. Kim E, Moore J, Huang J, Soffer S, Manley CA, O'Toole K, Middlesworth W, Stolar CJ, Kandel JJ, Yamashiro DJ. All angiogenesis is not the same: Distinct patterns of response to antiangiogenic therapy in experimental neuroblastoma and Wilms tumor. J Pediatr Surg. 2001 Feb; 36(2):287-90. PMID: 11172417.
      Citations: 6     Fields:    Translation:HumansAnimals
    79. Rowe DH, Huang J, Li J, Manley C, O'Toole KM, Stolar CJ, Yamashiro DJ, Kandel JJ. Suppression of primary tumor growth in a mouse model of human neuroblastoma. J Pediatr Surg. 2000 Jun; 35(6):977-81. PMID: 10873048.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    80. Rowe DH, Huang J, Kayton ML, Thompson R, Troxel A, O'Toole KM, Yamashiro D, Stolar CJ, Kandel JJ. Anti-VEGF antibody suppresses primary tumor growth and metastasis in an experimental model of Wilms' tumor. J Pediatr Surg. 2000 Jan; 35(1):30-2; discussion 32-3. PMID: 10646769.
      Citations: 25     Fields:    Translation:AnimalsCells
    81. Schwarz MA, Kandel J, Brett J, Li J, Hayward J, Schwarz RE, Chappey O, Wautier JL, Chabot J, Lo Gerfo P, Stern D. Endothelial-monocyte activating polypeptide II, a novel antitumor cytokine that suppresses primary and metastatic tumor growth and induces apoptosis in growing endothelial cells. J Exp Med. 1999 Aug 02; 190(3):341-54. PMID: 10430623; PMCID: PMC2195582.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    82. Kayton ML, Rowe DH, O'Toole KM, Thompson RB, Schwarz MA, Stolar CJ, Kandel JJ. Metastasis correlates with production of vascular endothelial growth factor in a murine model of human Wilms' tumor. J Pediatr Surg. 1999 May; 34(5):743-7; discussion 747-8. PMID: 10359175.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    83. Rowe DH, Kayton ML, O'Toole KM, Ingram M, Stolar CJ, Kandel JJ. Pathological angiogenesis in a murine model of human Wilms' tumor. J Pediatr Surg. 1999 May; 34(5):676-9. PMID: 10359162.
      Citations: 2     Fields:    Translation:AnimalsCells
    84. Marvin MR, Kayton ML, O'Toole KM, Rowe DH, DeRosa C, Kindred A, Trokhan S, Chabot J, Kandel JJ. A metastasizing model of anaplastic human Wilms tumor in the nude mouse. Eur J Pediatr Surg. 1998 Oct; 8(5):295-8. PMID: 9825240.
      Citations: 3     Fields:    Translation:HumansAnimals
    85. Thurston GM, Hayden DL, Burrows P, Clark JI, Taret VG, Kandel J, Courogen M, Peetermans JA, Bowen MS, Miller D, Sullivan KM, Storb R, Stern H, Benedek GB. Quasielastic light scattering study of the living human lens as a function of age. Curr Eye Res. 1997 Mar; 16(3):197-207. PMID: 9088735.
      Citations: 11     Fields:    Translation:Humans
    86. Duffy FJ, Seiler JG, Hergrueter CA, Kandel J, Gelberman RH. Intrinsic mitogenic potential of canine flexor tendons. J Hand Surg Br. 1992 Jun; 17(3):275-7. PMID: 1624859.
      Citations: 7     Fields:    Translation:AnimalsCells
    87. Kandel J, Bossy-Wetzel E, Radvanyi F, Klagsbrun M, Folkman J, Hanahan D. Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Cell. 1991 Sep 20; 66(6):1095-104. PMID: 1717155.
      Citations: 98     Fields:    Translation:AnimalsCells
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