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Sonia Hernandez

TitleResearch Associate Professor
InstitutionUniversity of Chicago
DepartmentSurgery-Pediatric
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Marquez M, Flores-Guzman F, Iwanicki I, Wu L, Villa-Gomez J, Viza-Gomes P, Sundland R, Ghaderi M, Frolova LV, Sirsi SR, Tartis M, Hernandez SL. Stabilized phospholipid-topotecan prodrug particles increase vascular permeability and ultrasound-enhanced neuroblastoma delivery. Int J Pharm. 2026 Oct 05; 703:127283. PMID: 42562131.
      Citations:    Fields:    
    2. Singh M, Saucedo E, Schade GR, Trivedi V, Singh AK, Shekhar H, Maxwell AD, Hernandez SL, Khan A, Bader KB. Preclinical Assessment of an Image-Guided Histotripsy System for Renal Ablation. IEEE Trans Biomed Eng. 2026 May 14; PP. PMID: 42133509.
      Citations:    Fields:    
    3. Antonides-Jensen N, Singh M, Xue Y, Flores-Guzman F, Wu LL, Yee SS, Gomez-Villa J, Hall TL, Applebaum MA, Bader KB, Hernandez SL. Histotripsy-Initiated Immune Response Synergizes with Chemotherapy in a Neuroblastoma Murine Model. Cancers (Basel). 2026 Apr 15; 18(8). PMID: 42073574; PMCID: PMC13114721.
      Citations:    
    4. Antonides-Jensen N, Singh M, Xue Y, Flores-Guzman F, Wu LL, Yee SS, Gomez-Villa J, Hall TL, Applebaum MA, Bader KB, Hernandez SL. Histotripsy-initiated immune response synergizes with chemotherapy in a neuroblastoma murine model. bioRxiv. 2026 Feb 03. PMID: 41676730; PMCID: PMC12889550.
      Citations:    
    5. Przanowska R, Gomez-Villa J, Liu VJ, Antonides-Jensen N, Visvabharathy L, Alverdy JC, Hernandez SL, Yee SS. IL-6R blockade with tocilizumab disrupts pericyte- and tumor cell-driven IL-6/STAT3 signaling, enhancing docetaxel efficacy in ER+ breast cancer. bioRxiv. 2026 Jan 30. PMID: 41659608; PMCID: PMC12873853.
      Citations:    
    6. Canul-Euan AA, Mendoza-Ortega JA, Solis-Paredes JM, Borboa-Olivares H, Martínez-Medina S, Hernández-Chávez C, Gil-Martínez G, Osorio-Valencia E, Torres-Calapiz M, Suárez-Rico BV, González-Ludlow I, Rodríguez-Hernández C, Rodríguez-Cano A, Reyes-Muñoz E, Camacho-Arroyo I, Hernandez SL, Perichart-Perera O, Estrada-Gutierrez G. Maternal Overweight and Obesity Alter Neurodevelopmental Trajectories During the First Year of Life: Findings from the OBESO Cohort. Children (Basel). 2025 Oct 14; 12(10). PMID: 41153569; PMCID: PMC12564623.
      Citations:    
    7. Sundland RM, Ballan D, Callier KM, Ayemoba J, Bellary A, Iwanicki IJ, Wu LL, Larkins T, Flores-Guzman F, Gomez-Villa J, Wyles G, Feshitan J, Kandel JJ, Sirsi SR, Hernandez SL. Sonopermeation With Size-sorted Microbubbles Synergistically Increases Survival and Enhances Tumor Apoptosis With L-DOX by Increasing Vascular Permeability and Perfusion in Neuroblastoma Xenografts. Ultrasound Med Biol. 2025 02; 51(2):348-357. PMID: 39581819; PMCID: PMC11677626.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    8. Miao K, Basterrechea KF, Hernandez SL, Ahmed OS, Patel MV, Bader KB. Development of Convolutional Neural Network to Segment Ultrasound Images of Histotripsy Ablation. IEEE Trans Biomed Eng. 2024 06; 71(6):1789-1797. PMID: 38198256.
      Citations: 4     Fields:    Translation:Animals
    9. Bellary A, Nowak C, Iwanicki I, Flores-Guzman F, Wu L, Kandel JJ, Laetsch TW, Bleris L, Hernandez SL, Sirsi SR. Non-viral nitric oxide-based gene therapy improves perfusion and liposomal doxorubicin sonopermeation in neuroblastoma models. Theranostics. 2023; 13(10):3402-3418. PMID: 37351172; PMCID: PMC10283050.
      Citations: 10     Fields:    Translation:HumansCells
    10. Iwanicki I, Wu LL, Flores-Guzman F, Sundland R, Viza-Gomes P, Nordgren R, Centner CS, Kandel JJ, Applebaum MA, Bader KB, Hernandez SL. Histotripsy induces apoptosis and reduces hypoxia in a neuroblastoma xenograft model. Int J Hyperthermia. 2023; 40(1):2222941. PMID: 37344380.
      Citations: 14     Fields:    Translation:HumansAnimals
    11. Wallach EL, Shekhar H, Flores-Guzman F, Hernandez SL, Bader KB. Histotripsy Bubble Cloud Contrast With Chirp-Coded Excitation in Preclinical Models. IEEE Trans Ultrason Ferroelectr Freq Control. 2022 02; 69(2):787-794. PMID: 34748487; PMCID: PMC11652668.
      Citations: 4     Fields:    Translation:Animals
    12. Bader KB, Wallach EL, Shekhar H, Flores-Guzman F, Halpern HJ, Hernandez SL. Estimating the mechanical energy of histotripsy bubble clouds with high frame rate imaging. Phys Med Biol. 2021 08 05; 66(16). PMID: 34271560; PMCID: PMC10680990.
      Citations: 4     Fields:    Translation:Animals
    13. Bellary A, Villarreal A, Eslami R, Undseth QJ, Lec B, Defnet AM, Bagrodia N, Kandel JJ, Borden MA, Shaikh S, Chopra R, Laetsch TW, Delaney LJ, Shaw CM, Eisenbrey JR, Hernandez SL, Sirsi SR. Perfusion-guided sonopermeation of neuroblastoma: a novel strategy for monitoring and predicting liposomal doxorubicin uptake in vivo. Theranostics. 2020; 10(18):8143-8161. PMID: 32724463; PMCID: PMC7381728.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    14. Yokomizo H, Maeda Y, Park K, Clermont AC, Hernandez SL, Fickweiler W, Li Q, Wang CH, Paniagua SM, Simao F, Ishikado A, Sun B, Wu IH, Katagiri S, Pober DM, Tinsley LJ, Avery RL, Feener EP, Kern TS, Keenan HA, Aiello LP, Sun JK, King GL. Retinol binding protein 3 is increased in the retina of patients with diabetes resistant to diabetic retinopathy. Sci Transl Med. 2019 07 03; 11(499). PMID: 31270273; PMCID: PMC7132633.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    15. Aguayo-Mazzucato C, Diaque P, Hernandez S, Rosas S, Kostic A, Caballero AE. Understanding the growing epidemic of type 2 diabetes in the Hispanic population living in the United States. Diabetes Metab Res Rev. 2019 02; 35(2):e3097. PMID: 30445663; PMCID: PMC6953173.
      Citations: 126     Fields:    Translation:Humans
    16. Hernandez SL, Nelson M, Sampedro GR, Bagrodia N, Defnet AM, Lec B, Emolo J, Kirschner R, Wu L, Biermann H, Shen S, Bubeck Wardenburg J, Kandel JJ. Staphylococcus aureus alpha toxin activates Notch in vascular cells. Angiogenesis. 2019 02; 22(1):197-209. PMID: 30324336; PMCID: PMC6360126.
      Citations: 10     Fields:    Translation:HumansCells
    17. Shakhsheer BA, Lec B, Zaborin A, Guyton K, Defnet AM, Bagrodia N, Kandel JJ, Zaborina O, Hernandez SL, Alverdy J. Lack of evidence for tissue hypoxia as a contributing factor in anastomotic leak following colon anastomosis and segmental devascularization in rats. Int J Colorectal Dis. 2017 Apr; 32(4):539-547. PMID: 27999936.
      Citations: 11     Fields:    Translation:Animals
    18. Defnet AM, Bagrodia N, Hernandez SL, Gwilliam N, Kandel JJ. Pediatric lymphatic malformations: evolving understanding and therapeutic options. Pediatr Surg Int. 2016 May; 32(5):425-33. PMID: 26815877.
      Citations: 28     Fields:    Translation:Humans
    19. Jani A, Shaikh F, Barton S, Willis C, Banerjee D, Mitchell J, Hernandez SL, Hei T, Kadenhe-Chiweshe A, Yamashiro DJ, Connolly EP. High-Dose, Single-Fraction Irradiation Rapidly Reduces Tumor Vasculature and Perfusion in a Xenograft Model of Neuroblastoma. Int J Radiat Oncol Biol Phys. 2016 Apr 01; 94(5):1173-80. PMID: 26907918.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    20. Banerjee D, Hernandez SL, Garcia A, Kangsamaksin T, Sbiroli E, Andrews J, Forrester LA, Wei N, Kadenhe-Chiweshe A, Shawber CJ, Kitajewski JK, Kandel JJ, Yamashiro DJ. Notch suppresses angiogenesis and progression of hepatic metastases. Cancer Res. 2015 Apr 15; 75(8):1592-602. PMID: 25744722; PMCID: PMC4401639.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    21. Hernandez SL, Gong JH, Chen L, Wu IH, Sun JK, Keenan HA, King GL. Characterization of circulating and endothelial progenitor cells in patients with extreme-duration type 1 diabetes. Diabetes Care. 2014 Aug; 37(8):2193-201. PMID: 24780357; PMCID: PMC4113171.
      Citations: 26     Fields:    Translation:HumansCells
    22. Hernandez SL, Banerjee D, Garcia A, Kangsamaksin T, Cheng WY, Anastassiou D, Funahashi Y, Kadenhe-Chiweshe A, Shawber CJ, Kitajewski JK, Kandel JJ, Yamashiro DJ. Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesis. Vasc Cell. 2013 Sep 25; 5(1):17. PMID: 24066611; PMCID: PMC3849070.
      Citations: 21     
    23. Sirsi SR, Flexman ML, Vlachos F, Huang J, Hernandez SL, Kim HK, Johung TB, Gander JW, Reichstein AR, Lampl BS, Wang A, Hielscher AH, Kandel JJ, Yamashiro DJ, Borden MA. Contrast ultrasound imaging for identification of early responder tumor models to anti-angiogenic therapy. Ultrasound Med Biol. 2012 Jun; 38(6):1019-29. PMID: 22425376; PMCID: PMC3348332.
      Citations: 33     Fields:    Translation:Animals
    24. Flexman ML, Vlachos F, Kim HK, Sirsi SR, Huang J, Hernandez SL, Johung TB, Gander JW, Reichstein AR, Lampl BS, Wang A, Borden MA, Yamashiro DJ, Kandel JJ, Hielscher AH. Monitoring early tumor response to drug therapy with diffuse optical tomography. J Biomed Opt. 2012 Jan; 17(1):016014. PMID: 22352664; PMCID: PMC3380816.
      Citations: 11     Fields:    Translation:Animals
    25. Fisher JC, Gander JW, Haley MJ, Hernandez SL, Huang J, Chang YJ, Johung TB, Guarnieri P, O'Toole K, Yamashiro DJ, Kandel JJ. Inhibition of cyclo-oxygenase 2 reduces tumor metastasis and inflammatory signaling during blockade of vascular endothelial growth factor. Vasc Cell. 2011 Oct 06; 3:22. PMID: 21978392; PMCID: PMC3198683.
      Citations: 2     
    26. Sirsi SR, Hernandez SL, Zielinski L, Blomback H, Koubaa A, Synder M, Homma S, Kandel JJ, Yamashiro DJ, Borden MA. Polyplex-microbubble hybrids for ultrasound-guided plasmid DNA delivery to solid tumors. J Control Release. 2012 Jan 30; 157(2):224-34. PMID: 21945680; PMCID: PMC3822338.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    27. Zaghloul N, Hernandez SL, Bae JO, Huang J, Fisher JC, Lee A, Kadenhe-Chiweshe A, Kandel JJ, Yamashiro DJ. Vascular endothelial growth factor blockade rapidly elicits alternative proangiogenic pathways in neuroblastoma. Int J Oncol. 2009 Feb; 34(2):401-7. PMID: 19148474; PMCID: PMC3070359.
      Citations: 17     Fields:    Translation:HumansAnimals
    28. Funahashi Y, Hernandez SL, Das I, Ahn A, Huang J, Vorontchikhina M, Sharma A, Kanamaru E, Borisenko V, Desilva DM, Suzuki A, Wang X, Shawber CJ, Kandel JJ, Yamashiro DJ, Kitajewski J. A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis. Cancer Res. 2008 Jun 15; 68(12):4727-35. PMID: 18559519; PMCID: PMC3690602.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
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