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David Barefield

TitleFellow
InstitutionUniversity of Chicago
DepartmentMedicine
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Barefield DY, Yamakawa S, Tahtah I, Sell JJ, Broman M, Laforest B, Harris S, Alvarez-Arce A, Araujo KN, Puckelwartz MJ, Wasserstrom JA, Fishman GI, McNally EM, Barefield DY, Yamakawa S, Tahtah I, Sell JJ, Broman M, Laforest B, Harris S, Alvarez-Arce A, Araujo KN, Puckelwartz MJ, Wasserstrom JA, Fishman GI, McNally EM. Partial and complete loss of myosin binding protein H-like cause cardiac conduction defects. J Mol Cell Cardiol. 2022 08; 169:28-40. PMID: 35533732; PMCID: PMC9329245.
      Citations:    Fields:    Translation:HumansAnimals
    2. Salamone IM, Quattrocelli M, Barefield DY, Page PG, Tahtah I, Hadhazy M, Tomar G, McNally EM, Salamone IM, Quattrocelli M, Barefield DY, Page PG, Tahtah I, Hadhazy M, Tomar G, McNally EM. Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms. J Clin Invest. 2022 03 15; 132(6). PMID: 35143417; PMCID: PMC8920338.
      Citations: 5     Fields:    Translation:Animals
    3. Demonbreun AR, Fallon KS, Oosterbaan CC, Vaught LA, Reiser NL, Bogdanovic E, Velez MP, Salamone IM, Page PGT, Hadhazy M, Quattrocelli M, Barefield DY, Wood LD, Gonzalez JP, Morris C, McNally EM, Demonbreun AR, Fallon KS, Oosterbaan CC, Vaught LA, Reiser NL, Bogdanovic E, Velez MP, Salamone IM, Page PGT, Hadhazy M, Quattrocelli M, Barefield DY, Wood LD, Gonzalez JP, Morris C, McNally EM. Anti-latent TGF? binding protein 4 antibody improves muscle function and reduces muscle fibrosis in muscular dystrophy. Sci Transl Med. 2021 Sep 08; 13(610):eabf0376. PMID: 34516828; PMCID: PMC9559620.
      Citations: 6     Fields:    Translation:Humans
    4. Barefield DY, Sell JJ, Tahtah I, Kearns SD, McNally EM, Demonbreun AR, Barefield DY, Sell JJ, Tahtah I, Kearns SD, McNally EM, Demonbreun AR. Loss of dysferlin or myoferlin results in differential defects in excitation-contraction coupling in mouse skeletal muscle. Sci Rep. 2021 08 05; 11(1):15865. PMID: 34354129; PMCID: PMC8342512.
      Citations: 4     Fields:    Translation:AnimalsCells
    5. Gacita AM, Dellefave-Castillo L, Page PGT, Barefield DY, Wasserstrom JA, Puckelwartz MJ, Nobrega MA, McNally EM, Gacita AM, Dellefave-Castillo L, Page PGT, Barefield DY, Wasserstrom JA, Puckelwartz MJ, Nobrega MA, McNally EM. Altered Enhancer and Promoter Usage Leads to Differential Gene Expression in the Normal and Failed Human Heart. Circ Heart Fail. 2020 10; 13(10):e006926. PMID: 32993371; PMCID: PMC7577963.
      Citations: 6     Fields:    Translation:HumansCells
    6. Kuster DWD, Lynch TL, Barefield DY, Sivaguru M, Kuffel G, Zilliox MJ, Lee KH, Craig R, Namakkal-Soorappan R, Sadayappan S, Kuster DWD, Lynch TL, Barefield DY, Sivaguru M, Kuffel G, Zilliox MJ, Lee KH, Craig R, Namakkal-Soorappan R, Sadayappan S. Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy. Cardiovasc Res. 2019 12 01; 115(14):1986-1997. PMID: 31050699; PMCID: PMC6872972.
      Citations: 9     Fields:    Translation:AnimalsCells
    7. Demonbreun AR, Wyatt EJ, Fallon KS, Oosterbaan CC, Page PG, Hadhazy M, Quattrocelli M, Barefield DY, McNally EM, Demonbreun AR, Wyatt EJ, Fallon KS, Oosterbaan CC, Page PG, Hadhazy M, Quattrocelli M, Barefield DY, McNally EM. A gene-edited mouse model of limb-girdle muscular dystrophy 2C for testing exon skipping. Dis Model Mech. 2019 11 04; 13(2). PMID: 31582396; PMCID: PMC6906631.
      Citations: 10     Fields:    Translation:AnimalsCells
    8. Demonbreun AR, Fallon KS, Oosterbaan CC, Bogdanovic E, Warner JL, Sell JJ, Page PG, Quattrocelli M, Barefield DY, McNally EM, Demonbreun AR, Fallon KS, Oosterbaan CC, Bogdanovic E, Warner JL, Sell JJ, Page PG, Quattrocelli M, Barefield DY, McNally EM. Recombinant annexin A6 promotes membrane repair and protects against muscle injury. J Clin Invest. 2019 11 01; 129(11):4657-4670. PMID: 31545299; PMCID: PMC6819108.
      Citations: 25     Fields:    Translation:AnimalsCells
    9. Aubert G, Barefield DY, Demonbreun AR, Ramratnam M, Fallon KS, Warner JL, Rossi AE, Hadhazy M, Makielski JC, McNally EM, Aubert G, Barefield DY, Demonbreun AR, Ramratnam M, Fallon KS, Warner JL, Rossi AE, Hadhazy M, Makielski JC, McNally EM. Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective. JACC Basic Transl Sci. 2019 Apr; 4(2):251-268. PMID: 31061927; PMCID: PMC6488756.
      Citations: 2     
    10. Kim EY, Barefield DY, Vo AH, Gacita AM, Schuster EJ, Wyatt EJ, Davis JL, Dong B, Sun C, Page P, Dellefave-Castillo L, Demonbreun A, Zhang HF, McNally EM, Kim EY, Barefield DY, Vo AH, Gacita AM, Schuster EJ, Wyatt EJ, Davis JL, Dong B, Sun C, Page P, Dellefave-Castillo L, Demonbreun A, Zhang HF, McNally EM. Distinct pathological signatures in human cellular models of myotonic dystrophy subtypes. JCI Insight. 2019 03 21; 4(6). PMID: 30730308; PMCID: PMC6482996.
      Citations: 16     Fields:    Translation:HumansCells
    11. Barefield DY, McNamara JW, Lynch TL, Kuster DWD, Govindan S, Haar L, Wang Y, Taylor EN, Lorenz JN, Nieman ML, Zhu G, Luther PK, Varr? A, Dobrev D, Ai X, Janssen PML, Kass DA, Jones WK, Gilbert RJ, Sadayappan S, Barefield DY, McNamara JW, Lynch TL, Kuster DWD, Govindan S, Haar L, Wang Y, Taylor EN, Lorenz JN, Nieman ML, Zhu G, Luther PK, Varr? A, Dobrev D, Ai X, Janssen PML, Kass DA, Jones WK, Gilbert RJ, Sadayappan S. Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury. J Mol Cell Cardiol. 2019 04; 129:236-246. PMID: 30862451; PMCID: PMC7222036.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    12. Barefield DY, Garbincius JF, Barefield DY, Garbincius JF. Highlights from the American Heart Association's Basic Cardiovascular Science 2018 Scientific Sessions. J Am Heart Assoc. 2018 11 20; 7(22):e011097. PMID: 30571479; PMCID: PMC6404426.
      Citations: 2     Fields:    
    13. Ramratnam M, Kenny B, Kyle JW, Wiedmeyer B, Hacker TA, Barefield DY, McNally EM, Makielski JC, Ramratnam M, Kenny B, Kyle JW, Wiedmeyer B, Hacker TA, Barefield DY, McNally EM, Makielski JC. Transgenic overexpression of the SUR2A-55 splice variant in mouse heart reduces infract size and promotes protective mitochondrial function. Heliyon. 2018 Jul; 4(7):e00677. PMID: 29998196; PMCID: PMC6037880.
      Citations: 2     
    14. Barefield DY, Barefield DY. It Takes a Village to Train a Scientist. Circ Res. 2017 09 29; 121(8):908-909. PMID: 28963186; PMCID: PMC5679097.
      Citations:    Fields:    Translation:Humans
    15. Grimes KM, Barefield DY, Kumar M, McNamara JW, Weintraub ST, de Tombe PP, Sadayappan S, Buffenstein R, Grimes KM, Barefield DY, Kumar M, McNamara JW, Weintraub ST, de Tombe PP, Sadayappan S, Buffenstein R. The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent. Pflugers Arch. 2017 Dec; 469(12):1603-1613. PMID: 28780592; PMCID: PMC5856255.
      Citations: 7     Fields:    Translation:AnimalsCells
    16. Barefield DY, Puckelwartz MJ, Kim EY, Wilsbacher LD, Vo AH, Waters EA, Earley JU, Hadhazy M, Dellefave-Castillo L, Pesce LL, McNally EM, Barefield DY, Puckelwartz MJ, Kim EY, Wilsbacher LD, Vo AH, Waters EA, Earley JU, Hadhazy M, Dellefave-Castillo L, Pesce LL, McNally EM. Experimental Modeling Supports a Role for MyBP-HL as a Novel Myofilament Component in Arrhythmia and Dilated Cardiomyopathy. Circulation. 2017 Oct 17; 136(16):1477-1491. PMID: 28778945; PMCID: PMC5645234.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    17. Quattrocelli M, Barefield DY, Warner JL, Vo AH, Hadhazy M, Earley JU, Demonbreun AR, McNally EM, Quattrocelli M, Barefield DY, Warner JL, Vo AH, Hadhazy M, Earley JU, Demonbreun AR, McNally EM. Intermittent glucocorticoid steroid dosing enhances muscle repair without eliciting muscle atrophy. J Clin Invest. 2017 Jun 01; 127(6):2418-2432. PMID: 28481224; PMCID: PMC5451235.
      Citations: 60     Fields:    Translation:AnimalsCells
    18. Barefield DY, Lynch TL, Jagadeesan A, Sanagala T, Sadayappan S, Barefield DY, Lynch TL, Jagadeesan A, Sanagala T, Sadayappan S. High-Throughput Diagnostic Assay for a Highly Prevalent Cardiomyopathy-Associated MYBPC3 Variant. J Mol Biomark Diagn. 2016 Nov; 7(6). PMID: 27990320; PMCID: PMC5160998.
      Citations: 3     
    19. Demonbreun AR, Quattrocelli M, Barefield DY, Allen MV, Swanson KE, McNally EM, Demonbreun AR, Quattrocelli M, Barefield DY, Allen MV, Swanson KE, McNally EM. An actin-dependent annexin complex mediates plasma membrane repair in muscle. J Cell Biol. 2016 06 20; 213(6):705-18. PMID: 27298325; PMCID: PMC4915191.
      Citations: 87     Fields:    Translation:AnimalsCells
    20. Demonbreun AR, Allen MV, Warner JL, Barefield DY, Krishnan S, Swanson KE, Earley JU, McNally EM, Demonbreun AR, Allen MV, Warner JL, Barefield DY, Krishnan S, Swanson KE, Earley JU, McNally EM. Enhanced Muscular Dystrophy from Loss of Dysferlin Is Accompanied by Impaired Annexin A6 Translocation after Sarcolemmal Disruption. Am J Pathol. 2016 06; 186(6):1610-22. PMID: 27070822; PMCID: PMC4901136.
      Citations: 17     Fields:    Translation:AnimalsCells
    21. Taylor EN, Hoffman MP, Barefield DY, Aninwene GE, Abrishamchi AD, Lynch TL, Govindan S, Osinska H, Robbins J, Sadayappan S, Gilbert RJ, Taylor EN, Hoffman MP, Barefield DY, Aninwene GE, Abrishamchi AD, Lynch TL, Govindan S, Osinska H, Robbins J, Sadayappan S, Gilbert RJ. Alterations in Multi-Scale Cardiac Architecture in Association With Phosphorylation of Myosin Binding Protein-C. J Am Heart Assoc. 2016 Mar 15; 5(3):e002836. PMID: 27068630; PMCID: PMC4943261.
      Citations: 11     Fields:    Translation:AnimalsCells
    22. Gao QQ, Wyatt E, Goldstein JA, LoPresti P, Castillo LM, Gazda A, Petrossian N, Earley JU, Hadhazy M, Barefield DY, Demonbreun AR, B?nnemann C, Wolf M, McNally EM, Gao QQ, Wyatt E, Goldstein JA, LoPresti P, Castillo LM, Gazda A, Petrossian N, Earley JU, Hadhazy M, Barefield DY, Demonbreun AR, B?nnemann C, Wolf M, McNally EM. Reengineering a transmembrane protein to treat muscular dystrophy using exon skipping. J Clin Invest. 2015 Nov 02; 125(11):4186-95. PMID: 26457733; PMCID: PMC4639981.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    23. Lynch TL, Sivaguru M, Velayutham M, Cardounel AJ, Michels M, Barefield D, Govindan S, dos Remedios C, van der Velden J, Sadayappan S, Lynch TL, Sivaguru M, Velayutham M, Cardounel AJ, Michels M, Barefield D, Govindan S, dos Remedios C, van der Velden J, Sadayappan S. Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation. Oxid Med Cell Longev. 2015; 2015:424751. PMID: 26508994; PMCID: PMC4609873.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    24. McNally EM, Barefield DY, Puckelwartz MJ, McNally EM, Barefield DY, Puckelwartz MJ. The genetic landscape of cardiomyopathy and its role in heart failure. Cell Metab. 2015 Feb 03; 21(2):174-182. PMID: 25651172; PMCID: PMC4331062.
      Citations: 48     Fields:    Translation:HumansAnimals
    25. Barefield D, Kumar M, Gorham J, Seidman JG, Seidman CE, de Tombe PP, Sadayappan S, Barefield D, Kumar M, Gorham J, Seidman JG, Seidman CE, de Tombe PP, Sadayappan S. Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice. J Mol Cell Cardiol. 2015 Feb; 79:234-43. PMID: 25463273; PMCID: PMC4642280.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    26. Hoffmann J, Ospelt M, Troidl C, Voss S, Liebetrau C, Kim WK, Rolf A, Wietelmann A, Braun T, Troidl K, Sadayappan S, Barefield D, Hamm C, Nef H, M?llmann H, Hoffmann J, Ospelt M, Troidl C, Voss S, Liebetrau C, Kim WK, Rolf A, Wietelmann A, Braun T, Troidl K, Sadayappan S, Barefield D, Hamm C, Nef H, M?llmann H. Sham surgery and inter-individual heterogeneity are major determinants of monocyte subset kinetics in a mouse model of myocardial infarction. PLoS One. 2014; 9(6):e98456. PMID: 24893162; PMCID: PMC4043649.
      Citations: 5     Fields:    Translation:AnimalsCells
    27. Wang L, Ji X, Barefield D, Sadayappan S, Kawai M, Wang L, Ji X, Barefield D, Sadayappan S, Kawai M. Phosphorylation of cMyBP-C affects contractile mechanisms in a site-specific manner. Biophys J. 2014 Mar 04; 106(5):1112-22. PMID: 24606935; PMCID: PMC4026776.
      Citations: 17     Fields:    Translation:AnimalsCells
    28. Barefield D, Kumar M, de Tombe PP, Sadayappan S, Barefield D, Kumar M, de Tombe PP, Sadayappan S. Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2014 Mar; 306(6):H807-15. PMID: 24464755; PMCID: PMC3949045.
      Citations: 29     Fields:    Translation:AnimalsCells
    29. Kuster DW, Barefield D, Govindan S, Sadayappan S, Kuster DW, Barefield D, Govindan S, Sadayappan S. A sensitive and specific quantitation method for determination of serum cardiac myosin binding protein-C by electrochemiluminescence immunoassay. J Vis Exp. 2013 Aug 08; (78). PMID: 23963065; PMCID: PMC3854717.
      Citations: 9     Fields:    Translation:Humans
    30. Verma SK, Krishnamurthy P, Barefield D, Singh N, Gupta R, Lambers E, Thal M, Mackie A, Hoxha E, Ramirez V, Qin G, Sadayappan S, Ghosh AK, Kishore R, Verma SK, Krishnamurthy P, Barefield D, Singh N, Gupta R, Lambers E, Thal M, Mackie A, Hoxha E, Ramirez V, Qin G, Sadayappan S, Ghosh AK, Kishore R. Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-?B. Circulation. 2012 Jul 24; 126(4):418-29. PMID: 22705886; PMCID: PMC3422741.
      Citations: 71     Fields:    Translation:AnimalsCells
    31. Govindan S, McElligott A, Muthusamy S, Nair N, Barefield D, Martin JL, Gongora E, Greis KD, Luther PK, Winegrad S, Henderson KK, Sadayappan S, Govindan S, McElligott A, Muthusamy S, Nair N, Barefield D, Martin JL, Gongora E, Greis KD, Luther PK, Winegrad S, Henderson KK, Sadayappan S. Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction. J Mol Cell Cardiol. 2012 Jan; 52(1):154-64. PMID: 21971072; PMCID: PMC3246118.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    32. Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown JH, Bers DM, Molkentin JD, James J, Robbins J, Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown JH, Bers DM, Molkentin JD, James J, Robbins J. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res. 2011 Jul 08; 109(2):141-50. PMID: 21597010; PMCID: PMC3132348.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    33. Barefield D, Sadayappan S, Barefield D, Sadayappan S. Phosphorylation and function of cardiac myosin binding protein-C in health and disease. J Mol Cell Cardiol. 2010 May; 48(5):866-75. PMID: 19962384; PMCID: PMC6800196.
      Citations: 152     Fields:    Translation:HumansAnimalsCells
    34. White R, Barefield D, Ram S, Work J, White R, Barefield D, Ram S, Work J. Peritoneal dialysis solutions reverse the hemodynamic effects of nitric oxide synthesis inhibitors. Kidney Int. 1995 Dec; 48(6):1986-93. PMID: 8587262.
      Citations: 1     Fields:    Translation:Animals
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