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David Barefield

TitleFellow
InstitutionUniversity of Chicago
DepartmentMedicine
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Elliott B, Márquez-Nogueras KM, Thuo P, DiNello E, Knutila RM, Fritzmann GE, Willis M, Chapman AB, Cao Q, Barefield DY, Kuo IY. Cardiac Localized Polycystin-2 plays a Functional Role in Natriuretic Peptide Production and its Absence Contributes to Hypertension. bioRxiv. 2024 Jan 02. PMID: 38260706; PMCID: PMC10802350.
      Citations:    
    2. Burnham HV, Cizauskas HE, Barefield DY. Fine tuning contractility: atrial sarcomere function in health and disease. Am J Physiol Heart Circ Physiol. 2024 Mar 01; 326(3):H568-H583. PMID: 38156887.
      Citations:    Fields:    Translation:Cells
    3. Barefield DY, Tonino P, Woulfe KC, Rahmanseresht S, O'Leary TS, Burnham HV, Wasserstrom JA, Kirk JA, Previs MJ, Granzier HL, McNally EM. Myosin-binding protein H-like regulates myosin-binding protein distribution and function in atrial cardiomyocytes. Proc Natl Acad Sci U S A. 2023 Dec 19; 120(51):e2314920120. PMID: 38091294; PMCID: PMC10741380.
      Citations:    Fields:    Translation:AnimalsCells
    4. Cizauskas HE, Burnham HV, Panni A, Pena A, Alvarez-Arce A, Davis MT, Araujo KN, Delligatti C, Edassery S, Kirk JA, Arora R, Barefield DY. Proteolytic degradation of atrial sarcomere proteins underlies contractile defects in atrial fibrillation. bioRxiv. 2023 Nov 05. PMID: 37961455; PMCID: PMC10635151.
      Citations:    
    5. Wren LM, DeKeyser JM, Barefield DY, Hawkins NA, McNally EM, Kearney JA, Wasserstrom JA, George AL. Sex and Gene Influence Arrhythmia Susceptibility in Murine Models of Calmodulinopathy. Circ Arrhythm Electrophysiol. 2023 09; 16(9):e010891. PMID: 37589122; PMCID: PMC10530303.
      Citations:    Fields:    Translation:Animals
    6. Barefield DY, Alvarez-Arce A, Araujo KN. Mechanisms of Sarcomere Protein Mutation-Induced Cardiomyopathies. Curr Cardiol Rep. 2023 06; 25(6):473-484. PMID: 37060436.
      Citations: 2     Fields:    Translation:HumansCells
    7. Barefield DY. Is haploinsufficiency a sufficient mechanism for MYBPC3 truncating mutations? J Gen Physiol. 2023 04 03; 155(4). PMID: 36946992; PMCID: PMC10072154.
      Citations:    Fields:    Translation:Humans
    8. Barefield DY, Yamakawa S, Tahtah I, Sell JJ, Broman M, Laforest B, Harris S, Alvarez-Arce A, Araujo KN, Puckelwartz MJ, Wasserstrom JA, Fishman GI, McNally EM. Partial and complete loss of myosin binding protein H-like cause cardiac conduction defects. J Mol Cell Cardiol. 2022 08; 169:28-40. PMID: 35533732; PMCID: PMC9329245.
      Citations: 2     Fields:    Translation:HumansAnimals
    9. Salamone IM, Quattrocelli M, Barefield DY, Page PG, Tahtah I, Hadhazy M, Tomar G, McNally EM. Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms. J Clin Invest. 2022 03 15; 132(6). PMID: 35143417; PMCID: PMC8920338.
      Citations: 9     Fields:    Translation:Animals
    10. Demonbreun AR, Fallon KS, Oosterbaan CC, Vaught LA, Reiser NL, Bogdanovic E, Velez MP, Salamone IM, Page PGT, Hadhazy M, Quattrocelli M, Barefield DY, Wood LD, Gonzalez JP, Morris C, McNally EM. Anti-latent TGFß binding protein 4 antibody improves muscle function and reduces muscle fibrosis in muscular dystrophy. Sci Transl Med. 2021 Sep 08; 13(610):eabf0376. PMID: 34516828; PMCID: PMC9559620.
      Citations: 12     Fields:    Translation:Humans
    11. Barefield DY, Sell JJ, Tahtah I, Kearns SD, McNally EM, Demonbreun AR. Loss of dysferlin or myoferlin results in differential defects in excitation-contraction coupling in mouse skeletal muscle. Sci Rep. 2021 08 05; 11(1):15865. PMID: 34354129; PMCID: PMC8342512.
      Citations: 4     Fields:    Translation:AnimalsCells
    12. Gacita AM, Dellefave-Castillo L, Page PGT, Barefield DY, Wasserstrom JA, Puckelwartz MJ, Nobrega MA, McNally EM. Altered Enhancer and Promoter Usage Leads to Differential Gene Expression in the Normal and Failed Human Heart. Circ Heart Fail. 2020 10; 13(10):e006926. PMID: 32993371; PMCID: PMC7577963.
      Citations: 9     Fields:    Translation:HumansCells
    13. Kuster DWD, Lynch TL, Barefield DY, Sivaguru M, Kuffel G, Zilliox MJ, Lee KH, Craig R, Namakkal-Soorappan R, Sadayappan S. Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy. Cardiovasc Res. 2019 12 01; 115(14):1986-1997. PMID: 31050699; PMCID: PMC6872972.
      Citations: 15     Fields:    Translation:AnimalsCells
    14. Demonbreun AR, Wyatt EJ, Fallon KS, Oosterbaan CC, Page PG, Hadhazy M, Quattrocelli M, Barefield DY, McNally EM. A gene-edited mouse model of limb-girdle muscular dystrophy 2C for testing exon skipping. Dis Model Mech. 2019 11 04; 13(2). PMID: 31582396; PMCID: PMC6906631.
      Citations: 11     Fields:    Translation:AnimalsCells
    15. Demonbreun AR, Fallon KS, Oosterbaan CC, Bogdanovic E, Warner JL, Sell JJ, Page PG, Quattrocelli M, Barefield DY, McNally EM. Recombinant annexin A6 promotes membrane repair and protects against muscle injury. J Clin Invest. 2019 11 01; 129(11):4657-4670. PMID: 31545299; PMCID: PMC6819108.
      Citations: 26     Fields:    Translation:AnimalsCells
    16. Aubert G, Barefield DY, Demonbreun AR, Ramratnam M, Fallon KS, Warner JL, Rossi AE, Hadhazy M, Makielski JC, McNally EM. Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective. JACC Basic Transl Sci. 2019 Apr; 4(2):251-268. PMID: 31061927; PMCID: PMC6488756.
      Citations: 3     
    17. Kim EY, Barefield DY, Vo AH, Gacita AM, Schuster EJ, Wyatt EJ, Davis JL, Dong B, Sun C, Page P, Dellefave-Castillo L, Demonbreun A, Zhang HF, McNally EM. Distinct pathological signatures in human cellular models of myotonic dystrophy subtypes. JCI Insight. 2019 03 21; 4(6). PMID: 30730308; PMCID: PMC6482996.
      Citations: 18     Fields:    Translation:HumansCells
    18. Barefield DY, McNamara JW, Lynch TL, Kuster DWD, Govindan S, Haar L, Wang Y, Taylor EN, Lorenz JN, Nieman ML, Zhu G, Luther PK, Dobrev D, Ai X, Janssen PML, Kass DA, Jones WK, Gilbert RJ, Sadayappan S, Varró A. Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury. J Mol Cell Cardiol. 2019 04; 129:236-246. PMID: 30862451; PMCID: PMC7222036.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    19. Barefield DY, Garbincius JF. Highlights from the American Heart Association's Basic Cardiovascular Science 2018 Scientific Sessions. J Am Heart Assoc. 2018 11 20; 7(22):e011097. PMID: 30571479; PMCID: PMC6404426.
      Citations: 2     Fields:    
    20. Ramratnam M, Kenny B, Kyle JW, Wiedmeyer B, Hacker TA, Barefield DY, McNally EM, Makielski JC. Transgenic overexpression of the SUR2A-55 splice variant in mouse heart reduces infract size and promotes protective mitochondrial function. Heliyon. 2018 Jul; 4(7):e00677. PMID: 29998196; PMCID: PMC6037880.
      Citations: 3     
    21. Barefield DY. It Takes a Village to Train a Scientist. Circ Res. 2017 09 29; 121(8):908-909. PMID: 28963186; PMCID: PMC5679097.
      Citations:    Fields:    Translation:Humans
    22. Grimes KM, Barefield DY, Kumar M, McNamara JW, Weintraub ST, de Tombe PP, Sadayappan S, Buffenstein R. The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent. Pflugers Arch. 2017 Dec; 469(12):1603-1613. PMID: 28780592; PMCID: PMC5856255.
      Citations: 8     Fields:    Translation:AnimalsCells
    23. Barefield DY, Puckelwartz MJ, Kim EY, Wilsbacher LD, Vo AH, Waters EA, Earley JU, Hadhazy M, Dellefave-Castillo L, Pesce LL, McNally EM. Experimental Modeling Supports a Role for MyBP-HL as a Novel Myofilament Component in Arrhythmia and Dilated Cardiomyopathy. Circulation. 2017 Oct 17; 136(16):1477-1491. PMID: 28778945; PMCID: PMC5645234.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    24. Quattrocelli M, Barefield DY, Warner JL, Vo AH, Hadhazy M, Earley JU, Demonbreun AR, McNally EM. Intermittent glucocorticoid steroid dosing enhances muscle repair without eliciting muscle atrophy. J Clin Invest. 2017 Jun 01; 127(6):2418-2432. PMID: 28481224; PMCID: PMC5451235.
      Citations: 67     Fields:    Translation:AnimalsCells
    25. Barefield DY, Lynch TL, Jagadeesan A, Sanagala T, Sadayappan S. High-Throughput Diagnostic Assay for a Highly Prevalent Cardiomyopathy-Associated MYBPC3 Variant. J Mol Biomark Diagn. 2016 Nov; 7(6). PMID: 27990320; PMCID: PMC5160998.
      Citations: 3     
    26. Demonbreun AR, Quattrocelli M, Barefield DY, Allen MV, Swanson KE, McNally EM. An actin-dependent annexin complex mediates plasma membrane repair in muscle. J Cell Biol. 2016 06 20; 213(6):705-18. PMID: 27298325; PMCID: PMC4915191.
      Citations: 101     Fields:    Translation:AnimalsCells
    27. Demonbreun AR, Allen MV, Warner JL, Barefield DY, Krishnan S, Swanson KE, Earley JU, McNally EM. Enhanced Muscular Dystrophy from Loss of Dysferlin Is Accompanied by Impaired Annexin A6 Translocation after Sarcolemmal Disruption. Am J Pathol. 2016 06; 186(6):1610-22. PMID: 27070822; PMCID: PMC4901136.
      Citations: 16     Fields:    Translation:AnimalsCells
    28. Taylor EN, Hoffman MP, Barefield DY, Aninwene GE, Abrishamchi AD, Lynch TL, Govindan S, Osinska H, Robbins J, Sadayappan S, Gilbert RJ. Alterations in Multi-Scale Cardiac Architecture in Association With Phosphorylation of Myosin Binding Protein-C. J Am Heart Assoc. 2016 Mar 15; 5(3):e002836. PMID: 27068630; PMCID: PMC4943261.
      Citations: 12     Fields:    Translation:AnimalsCells
    29. Gao QQ, Wyatt E, Goldstein JA, LoPresti P, Castillo LM, Gazda A, Petrossian N, Earley JU, Hadhazy M, Barefield DY, Demonbreun AR, Wolf M, McNally EM, Bönnemann C. Reengineering a transmembrane protein to treat muscular dystrophy using exon skipping. J Clin Invest. 2015 Nov 02; 125(11):4186-95. PMID: 26457733; PMCID: PMC4639981.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    30. Lynch TL, Sivaguru M, Velayutham M, Cardounel AJ, Michels M, Barefield D, Govindan S, dos Remedios C, van der Velden J, Sadayappan S. Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation. Oxid Med Cell Longev. 2015; 2015:424751. PMID: 26508994; PMCID: PMC4609873.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    31. McNally EM, Barefield DY, Puckelwartz MJ. The genetic landscape of cardiomyopathy and its role in heart failure. Cell Metab. 2015 Feb 03; 21(2):174-182. PMID: 25651172; PMCID: PMC4331062.
      Citations: 59     Fields:    Translation:HumansAnimals
    32. Barefield D, Kumar M, Gorham J, Seidman JG, Seidman CE, de Tombe PP, Sadayappan S. Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice. J Mol Cell Cardiol. 2015 Feb; 79:234-43. PMID: 25463273; PMCID: PMC4642280.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    33. Hoffmann J, Ospelt M, Troidl C, Voss S, Liebetrau C, Kim WK, Rolf A, Wietelmann A, Braun T, Troidl K, Sadayappan S, Barefield D, Hamm C, Nef H, Möllmann H. Sham surgery and inter-individual heterogeneity are major determinants of monocyte subset kinetics in a mouse model of myocardial infarction. PLoS One. 2014; 9(6):e98456. PMID: 24893162; PMCID: PMC4043649.
      Citations: 4     Fields:    Translation:AnimalsCells
    34. Wang L, Ji X, Barefield D, Sadayappan S, Kawai M. Phosphorylation of cMyBP-C affects contractile mechanisms in a site-specific manner. Biophys J. 2014 Mar 04; 106(5):1112-22. PMID: 24606935; PMCID: PMC4026776.
      Citations: 17     Fields:    Translation:AnimalsCells
    35. Barefield D, Kumar M, de Tombe PP, Sadayappan S. Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2014 Mar; 306(6):H807-15. PMID: 24464755; PMCID: PMC3949045.
      Citations: 35     Fields:    Translation:AnimalsCells
    36. Kuster DW, Barefield D, Govindan S, Sadayappan S. A sensitive and specific quantitation method for determination of serum cardiac myosin binding protein-C by electrochemiluminescence immunoassay. J Vis Exp. 2013 Aug 08; (78). PMID: 23963065; PMCID: PMC3854717.
      Citations: 10     Fields:    Translation:Humans
    37. Verma SK, Krishnamurthy P, Barefield D, Singh N, Gupta R, Lambers E, Thal M, Mackie A, Hoxha E, Ramirez V, Qin G, Sadayappan S, Ghosh AK, Kishore R. Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-?B. Circulation. 2012 Jul 24; 126(4):418-29. PMID: 22705886; PMCID: PMC3422741.
      Citations: 76     Fields:    Translation:AnimalsCells
    38. Govindan S, McElligott A, Muthusamy S, Nair N, Barefield D, Martin JL, Gongora E, Greis KD, Luther PK, Winegrad S, Henderson KK, Sadayappan S. Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction. J Mol Cell Cardiol. 2012 Jan; 52(1):154-64. PMID: 21971072; PMCID: PMC3246118.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    39. Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown JH, Bers DM, Molkentin JD, James J, Robbins J. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res. 2011 Jul 08; 109(2):141-50. PMID: 21597010; PMCID: PMC3132348.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    40. Barefield D, Sadayappan S. Phosphorylation and function of cardiac myosin binding protein-C in health and disease. J Mol Cell Cardiol. 2010 May; 48(5):866-75. PMID: 19962384; PMCID: PMC6800196.
      Citations: 162     Fields:    Translation:HumansAnimalsCells
    41. White R, Barefield D, Ram S, Work J. Peritoneal dialysis solutions reverse the hemodynamic effects of nitric oxide synthesis inhibitors. Kidney Int. 1995 Dec; 48(6):1986-93. PMID: 8587262.
      Citations: 1     Fields:    Translation:Animals
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