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Asish Ghosh

TitleResearch Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Cardiology
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    Academic Interests: Dr. Ghosh’s major research interest focuses on the molecular, genetic, and epigenetic regulation of chronological and stress-induced accelerated cellular senescence and aging-associated cardiovascular disease. Using genetic and pharmacologic approaches, Dr. Ghosh originally demonstrated the essential role of a major epigenetic regulator, acetyltransferase p300 in profibrogenic signal-induced collagen synthesis and fibrogenesis. Dr. Ghosh and colleagues further defined the significance of physical and functional interaction of p300 with several pro-fibrotic and anti-fibrotic regulators/transcription factors in controlling profibrogenic signaling and the synthesis of type I collagen, a major extracellular matrix protein in the fibrotic tissues. He is interested to investigate the impact of epigenetics in stressor-induced cellular senescence, and cardiac aging in an animal model of atrial fibrillation, and the underlying mechanisms using biochemical, immunocytochemistry, immunohisto-chemistry, transcriptomics and proteomics approaches. His goal is to continue doing innovative research on cardiac aging in collaboration with experts in the field of aging research, and to provide excellent guidance in research to students and trainees.

    Collapse Biography 
    Collapse education and training
    Calcutta University, Calcutta, IndiaPhDField of Study: Cytology and Genetics
    Chicago Medical School, Illinois, USAPostdoctoral FellowshipField of Study: Molecular Biology
    University of Poona, Pune, IndiaAMBO Training WorkshopUse of Cloned Genes in the Study of Development
    Jadavpur University, Calcutta, IndiaBiotechnology CourseGenetic Engineering
    Collapse awards and honors
    2020Elected Fellow of the American Heart Association , (FAHA)
    2004 - 2006Mark Flapan Award, National Scleroderma Foundation

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. O'Donnell C, Mikhailov A, Yoo S, Ghosh A, Arora R. Gene Therapies in Atrial Fibrillation. J Cardiovasc Transl Res. 2025 Oct 14. PMID: 41085934.
      Citations:    
    2. Rottmann M, Yoo S, Pfenniger A, Mikhailov A, Benefield B, Johnson DA, Zhang W, Ghosh AK, Kim D, Passman R, Knight BP, Lee DC, Arora R. Use of Atrial Fibrillation Electrograms and T1/T2 Magnetic Resonance Imaging to Define the Progressive Nature of Molecular and Structural Remodeling: A New Paradigm Underlying the Emergence of Persistent Atrial Fibrillation. J Am Heart Assoc. 2024 Mar 05; 13(5):e032514. PMID: 37930082; PMCID: PMC10944076.
      Citations:    Fields:    Translation:Animals
    3. Ghosh AK . Air-pollutant particulate matter 2.5 (PM2.5)-induced inflammation and oxidative stress in diseases: Possible therapeutic approaches. Int J Sci Res Arch. 2024; 11 (1):2148-2124. View Publication.
    4. Ghosh AK, Kalousdian AA, Shang M, Lux E, Eren M, Keating A, Wilsbacher LD, Vaughan DE. Cardiomyocyte PAI-1 influences the cardiac transcriptome and limits the extent of cardiac fibrosis in response to left ventricular pressure overload. Cell Signal. 2023 04; 104:110555. PMID: 36584735.
      Citations: 4     Fields:    Translation:AnimalsCells
    5. Ghosh AK. Acetyltransferase p300 Is a Putative Epidrug Target for Amelioration of Cellular Aging-Related Cardiovascular Disease. Cells. 2021 10 22; 10(11). PMID: 34831061; PMCID: PMC8616404.
      Citations: 16     Fields:    Translation:HumansAnimals
    6. Ghosh AK, Soberanes S, Lux E, Shang M, Aillon RP, Eren M, Budinger GRS, Miyata T, Vaughan DE. Pharmacological inhibition of PAI-1 alleviates cardiopulmonary pathologies induced by exposure to air pollutants PM2.5. Environ Pollut. 2021 Oct 15; 287:117283. PMID: 34426376; PMCID: PMC8434953.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    7. Ghosh AK. Pharmacological activation of PPAR-?: a potential therapy for skin fibrosis. Int J Dermatol. 2021 Mar; 60(3):376-383. PMID: 33377189.
      Citations: 8     Fields:    Translation:HumansCells
    8. Ghosh AK. p300 in Cardiac Development and Accelerated Cardiac Aging. Aging Dis. 2020 Jul; 11(4):916-926. PMID: 32765954; PMCID: PMC7390535.
      Citations: 32     Fields:    
    9. Sun T, Ghosh AK, Eren M, Miyata T, Vaughan DE. PAI-1 contributes to homocysteine-induced cellular senescence. Cell Signal. 2019 12; 64:109394. PMID: 31472244; PMCID: PMC6936332.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    10. Rai R, Sun T, Ramirez V, Lux E, Eren M, Vaughan DE, Ghosh AK. Acetyltransferase p300 inhibitor reverses hypertension-induced cardiac fibrosis. J Cell Mol Med. 2019 04; 23(4):3026-3031. PMID: 30710427; PMCID: PMC6433695.
      Citations: 46     Fields:    Translation:AnimalsCells
    11. Souma T, Thomson BR, Heinen S, Carota IA, Yamaguchi S, Onay T, Liu P, Ghosh AK, Li C, Eremina V, Hong YK, Economides AN, Vestweber D, Peters KG, Jin J, Quaggin SE. Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP. Proc Natl Acad Sci U S A. 2018 02 06; 115(6):1298-1303. PMID: 29358379; PMCID: PMC5819405.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    12. Ghosh AK, Vaughan DE. . Epigenetic treatment approaches to cardiovascular diseases. Chapter 22, in Book: Epigenetics in Human Disease, 2nd edition" Ed. T. Tollefsbol, Academic Press, Elsevier,. 2018; 607-641.
    13. Rai R, Verma SK, Kim D, Ramirez V, Lux E, Li C, Sahoo S, Wilsbacher LD, Vaughan DE, Quaggin SE, Ghosh AK. A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis. Epigenetics. 2017; 12(11):1004-1013. PMID: 28933600; PMCID: PMC5788418.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    14. Rai R, Ghosh AK, Eren M, Mackie AR, Levine DC, Kim SY, Cedernaes J, Ramirez V, Procissi D, Smith LH, Woodruff TK, Bass J, Vaughan DE. Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan. Cell Rep. 2017 Nov 07; 21(6):1471-1480. PMID: 29117554; PMCID: PMC5892413.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    15. Flevaris P, Khan SS, Eren M, Schuldt AJT, Shah SJ, Lee DC, Gupta S, Shapiro AD, Burridge PW, Ghosh AK, Vaughan DE. Plasminogen Activator Inhibitor Type I Controls Cardiomyocyte Transforming Growth Factor-ß and Cardiac Fibrosis. Circulation. 2017 Aug 15; 136(7):664-679. PMID: 28588076; PMCID: PMC5784400.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    16. Vaughan DE, Rai R, Khan SS, Eren M, Ghosh AK. Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence. Arterioscler Thromb Vasc Biol. 2017 08; 37(8):1446-1452. PMID: 28572158; PMCID: PMC5846199.
      Citations: 140     Fields:    Translation:HumansAnimalsCells
    17. Ghosh AK, Rai R, Flevaris P, Vaughan DE. Epigenetics in Reactive and Reparative Cardiac Fibrogenesis: The Promise of Epigenetic Therapy. J Cell Physiol. 2017 Aug; 232(8):1941-1956. PMID: 27883184.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    18. Ghosh AK, Rai R, Park KE, Eren M, Miyata T, Wilsbacher LD, Vaughan DE. A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence. Oncotarget. 2016 Nov 08; 7(45):72443-72457. PMID: 27736799; PMCID: PMC5341920.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    19. Nagpal V, Rai R, Place AT, Murphy SB, Verma SK, Ghosh AK, Vaughan DE. Response to Letter Regarding Article, "MiR-125b Is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis". Circulation. 2016 Jun 14; 133(24):e714. PMID: 27297354.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    20. Nagpal V, Rai R, Place AT, Murphy SB, Verma SK, Ghosh AK, Vaughan DE. MiR-125b Is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis. Circulation. 2016 Jan 19; 133(3):291-301. PMID: 26585673; PMCID: PMC5446084.
      Citations: 133     Fields:    Translation:HumansAnimalsCells
    21. Thomson BR, Heinen S, Jeansson M, Ghosh AK, Fatima A, Sung HK, Onay T, Chen H, Yamaguchi S, Economides AN, Flenniken A, Gale NW, Hong YK, Fawzi A, Liu X, Kume T, Quaggin SE. A lymphatic defect causes ocular hypertension and glaucoma in mice. J Clin Invest. 2014 Oct; 124(10):4320-4. PMID: 25202984; PMCID: PMC4191022.
      Citations: 107     Fields:    Translation:AnimalsCells
    22. Ghosh AK. FAT-free p300 is good for scar-free tissue repair. J Cell Biochem. 2014 Sep; 115(9):1486-9. PMID: 24733520.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    23. Maezawa Y, Onay T, Scott RP, Keir LS, Dimke H, Li C, Eremina V, Maezawa Y, Jeansson M, Shan J, Binnie M, Lewin M, Ghosh A, Miner JH, Vainio SJ, Quaggin SE. Loss of the podocyte-expressed transcription factor Tcf21/Pod1 results in podocyte differentiation defects and FSGS. J Am Soc Nephrol. 2014 Nov; 25(11):2459-70. PMID: 24904088; PMCID: PMC4214535.
      Citations: 36     Fields:    Translation:AnimalsCells
    24. Ghosh AK, Covington JW, Vaughan DE. . Isolation and Culture of Cardiac Endothelial Cells. In: Manual of Research Techniques in Cardiovascular Medicine: Chapter 15. Chicago, Eds. Ardehali, H., Bolli, R., Losordo, D.W., John Wiley & Sons, Ltd. 2014; 131-139.
    25. Ghosh AK, Covington JW, Vaughan DE. . Isolation and Culture of Cardiac Fibroblasts. In: Manual of Research Techniques in Cardiovascular Medicine: Chapter 16. Chicago, Eds. Ardehali, H., Bolli, R., Losordo, D.W., John Wiley & Sons, Ltd.,. 2014; 140-145.
    26. Ghosh AK, Murphy SB, Kishore R, Vaughan DE. Global gene expression profiling in PAI-1 knockout murine heart and kidney: molecular basis of cardiac-selective fibrosis. PLoS One. 2013; 8(5):e63825. PMID: 23724005; PMCID: PMC3665822.
      Citations: 24     Fields:    Translation:AnimalsCells
    27. Ghosh AK, Quaggin SE, Vaughan DE. Molecular basis of organ fibrosis: potential therapeutic approaches. Exp Biol Med (Maywood). 2013 May; 238(5):461-81. PMID: 23856899.
      Citations: 78     Fields:    Translation:HumansAnimals
    28. Yin H, Lo JH, Kim JY, Marsh EE, Kim JJ, Ghosh AK, Bulun S, Chakravarti D. Expression profiling of nuclear receptors identifies key roles of NR4A subfamily in uterine fibroids. Mol Endocrinol. 2013 May; 27(5):726-40. PMID: 23550059; PMCID: PMC3634117.
      Citations: 13     Fields:    Translation:HumansCells
    29. Ghosh AK, Bhattacharyya S, Lafyatis R, Farina G, Yu J, Thimmapaya B, Wei J, Varga J. p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-ß: epigenetic feed-forward amplification of fibrosis. J Invest Dermatol. 2013 May; 133(5):1302-10. PMID: 23303459; PMCID: PMC3626729.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    30. Verma SK, Krishnamurthy P, Barefield D, Singh N, Gupta R, Lambers E, Thal M, Mackie A, Hoxha E, Ramirez V, Qin G, Sadayappan S, Ghosh AK, Kishore R. Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-?B. Circulation. 2012 Jul 24; 126(4):418-29. PMID: 22705886; PMCID: PMC3422741.
      Citations: 97     Fields:    Translation:AnimalsCells
    31. Ghosh AK, Vaughan DE. PAI-1 in tissue fibrosis. J Cell Physiol. 2012 Feb; 227(2):493-507. PMID: 21465481; PMCID: PMC3204398.
      Citations: 359     Fields:    Translation:Humans
    32. Ghosh AK, Nagpal V, Covington JW, Michaels MA, Vaughan DE. Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): differential expression of microRNAs during EndMT. Cell Signal. 2012 May; 24(5):1031-6. PMID: 22245495; PMCID: PMC3298765.
      Citations: 87     Fields:    Translation:AnimalsCells
    33. Ghosh AK, Vaughan DE. Fibrosis: is it a coactivator disease? Front Biosci (Elite Ed). 2012 01 01; 4(4):1556-70. PMID: 22201975.
      Citations: 11     Fields:    Translation:Humans
    34. Budinger GR, Wu M, Lam AP, Zirk A, Rivera S, Urich D, Chiarella SE, Go LH, Ghosh AK, Selman M, Pardo A, Varga J, Kamp DW, Chandel NS, Sznajder JI, Jain M, Mutlu GM. Proteasomal inhibition after injury prevents fibrosis by modulating TGF-ß(1) signalling. Thorax. 2012 Feb; 67(2):139-46. PMID: 21921091; PMCID: PMC3595535.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    35. Jain M, Budinger GR, Lo A, Urich D, Rivera SE, Ghosh AK, Gonzalez A, Chiarella SE, Marks K, Donnelly HK, Soberanes S, Varga J, Radigan KA, Chandel NS, Mutlu GM. Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-?. Am J Respir Crit Care Med. 2011 Jun 01; 183(11):1490-8. PMID: 21317313; PMCID: PMC3266063.
      Citations: 68     Fields:    Translation:HumansAnimals
    36. Wei J, Ghosh AK, Sargent JL, Komura K, Wu M, Huang QQ, Jain M, Whitfield ML, Feghali-Bostwick C, Varga J. PPAR? downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis. PLoS One. 2010 Nov 02; 5(11):e13778. PMID: 21072170; PMCID: PMC2970611.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    37. Ghosh AK, Bradham WS, Gleaves LA, De Taeye B, Murphy SB, Covington JW, Vaughan DE. Genetic deficiency of plasminogen activator inhibitor-1 promotes cardiac fibrosis in aged mice: involvement of constitutive transforming growth factor-beta signaling and endothelial-to-mesenchymal transition. Circulation. 2010 Sep 21; 122(12):1200-9. PMID: 20823384.
      Citations: 66     Fields:    Translation:AnimalsCells
    38. Ghosh AK. TGF-beta signaling and its inhibition: implication in fibrosis. Editorial: Current Enzyme Inhibition. 2010; 6 (2):54-56. View Publication.
    39. Ghosh AK, Bhattacharyya S, Wei J, Kim S, Barak Y, Mori Y, Varga J. Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator. FASEB J. 2009 Sep; 23(9):2968-77. PMID: 19395477; PMCID: PMC2735362.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    40. Cai J, Yi FF, Yang L, Shen DF, Yang Q, Li A, Ghosh AK, Bian ZY, Yan L, Tang QZ, Li H, Yang XC. Targeted expression of receptor-associated late transducer inhibits maladaptive hypertrophy via blocking epidermal growth factor receptor signaling. Hypertension. 2009 Mar; 53(3):539-48. PMID: 19204184; PMCID: PMC2845399.
      Citations: 14     Fields:    Translation:AnimalsCells
    41. Wu M, Melichian DS, Chang E, Warner-Blankenship M, Ghosh AK, Varga J. Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma. Am J Pathol. 2009 Feb; 174(2):519-33. PMID: 19147827; PMCID: PMC2630560.
      Citations: 117     Fields:    Translation:AnimalsCells
    42. Ghosh AK, Wei J, Wu M, Varga J. Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-gamma. Biochem Biophys Res Commun. 2008 Sep 19; 374(2):231-6. PMID: 18627765; PMCID: PMC3157939.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    43. Li HL, Liu C, de Couto G, Ouzounian M, Sun M, Wang AB, Huang Y, He CW, Shi Y, Chen X, Nghiem MP, Liu Y, Chen M, Dawood F, Fukuoka M, Maekawa Y, Zhang L, Leask A, Ghosh AK, Kirshenbaum LA, Liu PP. Curcumin prevents and reverses murine cardiac hypertrophy. J Clin Invest. 2008 Mar; 118(3):879-93. PMID: 18292803; PMCID: PMC2248327.
      Citations: 42     Fields:    Translation:AnimalsCells
    44. Ghosh AK, Varga J. The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis. J Cell Physiol. 2007 Dec; 213(3):663-71. PMID: 17559085.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    45. Ghosh AK, Mori Y, Dowling E, Varga J. Trichostatin A blocks TGF-beta-induced collagen gene expression in skin fibroblasts: involvement of Sp1. Biochem Biophys Res Commun. 2007 Mar 09; 354(2):420-6. PMID: 17234156.
      Citations: 33     Fields:    Translation:HumansCells
    46. Ghosh AK, Bhattacharyya S, Mori Y, Varga J. Inhibition of collagen gene expression by interferon-gamma: novel role of the CCAAT/enhancer binding protein beta (C/EBPbeta). J Cell Physiol. 2006 Apr; 207(1):251-60. PMID: 16331681.
      Citations: 17     Fields:    Translation:HumansCells
    47. Ray D, Terao Y, Nimbalkar D, Chu LH, Donzelli M, Tsutsui T, Zou X, Ghosh AK, Varga J, Draetta GF, Kiyokawa H. Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner. Mol Cell Biol. 2005 Apr; 25(8):3338-47. PMID: 15798217; PMCID: PMC1069597.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    48. Bhattacharyya S, Ghosh AK, Pannu J, Mori Y, Takagawa S, Chen G, Trojanowska M, Gilliam AC, Varga J. Fibroblast expression of the coactivator p300 governs the intensity of profibrotic response to transforming growth factor beta. Arthritis Rheum. 2005 Apr; 52(4):1248-58. PMID: 15818659.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    49. Ghosh AK, Bhattacharyya S, Varga J. The tumor suppressor p53 abrogates Smad-dependent collagen gene induction in mesenchymal cells. J Biol Chem. 2004 Nov 12; 279(46):47455-63. PMID: 15345715.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    50. Ghosh AK, Bhattacharyya S, Lakos G, Chen SJ, Mori Y, Varga J. Disruption of transforming growth factor beta signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator-activated receptor gamma. Arthritis Rheum. 2004 Apr; 50(4):1305-18. PMID: 15077315.
      Citations: 88     Fields:    Translation:HumansCells
    51. Ghosh AK, Varga J. . Transcriptional coactivators p300/CBP and Type I collagen gene expression. Curr. Science. 2003; 85:155-161. View Publication.
    52. Ghosh AK. Factors involved in the regulation of type I collagen gene expression: implication in fibrosis. Exp Biol Med (Maywood). 2002 May; 227(5):301-14. PMID: 11976400.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    53. Ghosh AK, Yuan W, Mori Y, Varga J. Antagonistic regulation of type I collagen gene expression by interferon-gamma and transforming growth factor-beta. Integration at the level of p300/CBP transcriptional coactivators. J Biol Chem. 2001 Apr 06; 276(14):11041-8. PMID: 11134049.
      Citations: 61     Fields:    Translation:HumansCells
    54. Guo S, Cichy SB, He X, Yang Q, Ragland M, Ghosh AK, Johnson PF, Unterman TG. Insulin suppresses transactivation by CAAT/enhancer-binding proteins beta (C/EBPbeta). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPbeta. J Biol Chem. 2001 Mar 16; 276(11):8516-23. PMID: 11116148.
      Citations: 27     Fields:    Translation:Cells
    55. Ghosh AK, Lacson R, Liu P, Cichy SB, Danilkovich A, Guo S, Unterman TG. A nucleoprotein complex containing CCAAT/enhancer-binding protein beta interacts with an insulin response sequence in the insulin-like growth factor-binding protein-1 gene and contributes to insulin-regulated gene expression. J Biol Chem. 2001 Mar 16; 276(11):8507-15. PMID: 11116147.
      Citations: 10     Fields:    Translation:HumansCells
    56. Ghosh AK, Yuan W, Mori Y, Varga J. Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators. Oncogene. 2000 Jul 20; 19(31):3546-55. PMID: 10918613.
      Citations: 81     Fields:    Translation:HumansCells
    57. Jacob ST, Ghosh AK. . Control of RNA polymerase I-directed transcription: Recent trends. J Cell. Biochem. 1999; 32/33:41-50. View Publication.
    58. Ghosh AK, Jacob ST. . RNA polymerase I enhancers and enhancer-binding proteins. In: "Transcription of ribosomal RNA genes by eukaryotic RNA Polymerase I" Chapter18, Ed. Paule, M.R., R.G. Landes Company,. 1998; 229-239.
    59. Ghosh AK. Autoantigen Ku and its role in multiple cellular processes. Indian J Exp Biol. 1997 Dec; 35(12):1261-72. PMID: 9567759.
      Citations:    Fields:    Translation:HumansAnimalsCells
    60. Ghosh AK, Datta PK, Jacob ST. The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo. Oncogene. 1997 Feb 06; 14(5):589-94. PMID: 9053857.
      Citations: 9     Fields:    Translation:AnimalsCells
    61. Ghosh AK, Niu H, Jacob ST. Rat ribosomal RNA gene can utilize primate RNA polymerase I transcription machinery: lack of absolute species specificity in rDNA transcription. Biochem Biophys Res Commun. 1996 Aug 23; 225(3):890-5. PMID: 8780707.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    62. Datta PK, Ghosh AK, Jacob ST. The RNA polymerase I promoter-activating factor CPBF is functionally and immunologically related to the basic helix-loop-helix-zipper DNA-binding protein USF. J Biol Chem. 1995 Apr 14; 270(15):8637-41. PMID: 7721765.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    63. Ghosh AK, Kermekchiev M, Jacob ST. Effects of repetitive and non-repetitive rat rDNA enhancer elements on in vivo transcription by RNA polymerases I and II. Gene. 1994 Apr 20; 141(2):271-5. PMID: 8163201.
      Citations: 3     Fields:    Translation:AnimalsCells
    64. Hoff CM, Ghosh AK, Prabhakar BS, Jacob ST. Enhancer 1 binding factor, a Ku-related protein, is a positive regulator of RNA polymerase I transcription initiation. Proc Natl Acad Sci U S A. 1994 Jan 18; 91(2):762-6. PMID: 8290597; PMCID: PMC43029.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    65. Ghosh AK, Hoff CM, Jacob ST. Characterization of the 130-bp repeat enhancer element of the rat ribosomal gene: functional interaction with transcription factor E1BF. Gene. 1993 Mar 30; 125(2):217-22. PMID: 8462876.
      Citations: 10     Fields:    Translation:AnimalsCells
    66. Ghosh AK, Mukherjee AS. Replicative activity of X-chromosome and autosomes of Drosophila melanogaster in autosomal hyperploids and the problem of dosage compensation. Indian J Exp Biol. 1992 Jul; 30(7):557-66. PMID: 1459627.
      Citations:    Fields:    Translation:AnimalsCells
    67. Ghosh AK, Mukherjee AS. Expression of 87A, 87C and 93D heat shock puffs in trisomic (2L and 3L) strains of Drosophila melanogaster: evidence for a functional relation between 93D and 87C. Chromosoma. 1990 Apr; 99(1):71-5. PMID: 2111237.
      Citations: 1     Fields:    Translation:AnimalsCells
    68. Ghosh AK, Ghosh M, Mukherjee AS. . Autosomal dosage compensation in interspecific hybrids of Drosophila: I. Transcriptional activity in diploid and triploid hybrids. Current Science. 1989; 58:907-911. View Publication.
    69. Ghosh AK, Mukherjee AS. Transcriptive activity of right arm of 4th chromosome in Drosophila melanogaster in different doses and problem of autosomal dosage compensation. Indian J Exp Biol. 1988 May; 26(5):329-32. PMID: 3139554.
      Citations:    Fields:    Translation:AnimalsCells
    70. Ghosh AK. Transcriptive activity of a hyperploid autosomal arm in Drosophila melanogaster. Indian J Exp Biol. 1986 Sep; 24(9):555-60. PMID: 3104204.
      Citations:    Fields:    Translation:AnimalsCells
    71. Ghosh AK. . Effect of a hyperploid autosomal arm on different linked and unlinked loci in the genome of Drosophila melanogaster. In: Advances in Cytology and Genetics, Ed. Bhatnagar, V. S. p62-72, 1986.
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