2-Amino-5-phosphonovalerate
"2-Amino-5-phosphonovalerate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Descriptor ID |
D015763
|
| MeSH Number(s) |
D12.125.070.950.100 D12.125.740.025
|
| Concept/Terms |
2-Amino-5-phosphonovalerate- 2-Amino-5-phosphonovalerate
- 2 Amino 5 phosphonovalerate
- 5-Phosphononorvaline
- 5 Phosphononorvaline
- 2-Amino-5-phosphonovaleric Acid
- 2 Amino 5 phosphonovaleric Acid
- 2-APV
- 2-Amino-5-phosphonopentanoate
- 2 Amino 5 phosphonopentanoate
- 2-Amino-5-phosphonopentanoic Acid
- 2 Amino 5 phosphonopentanoic Acid
|
Below are MeSH descriptors whose meaning is more general than "2-Amino-5-phosphonovalerate".
Below are MeSH descriptors whose meaning is more specific than "2-Amino-5-phosphonovalerate".
This graph shows the total number of publications written about "2-Amino-5-phosphonovalerate" by people in this website by year, and whether "2-Amino-5-phosphonovalerate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "2-Amino-5-phosphonovalerate" by people in Profiles.
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Ethanol affects NMDA receptor signaling at climbing fiber-Purkinje cell synapses in mice and impairs cerebellar LTD. J Neurophysiol. 2013 Mar; 109(5):1333-42.
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In vivo electrical stimulation of rabbit retina: effect of stimulus duration and electrical field orientation. Exp Eye Res. 2006 Aug; 83(2):247-54.
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Is NMDA receptor activation essential for the production of locomotor-like activity in the neonatal rat spinal cord? J Neurophysiol. 2005 Dec; 94(6):3805-14.
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Caudal ventrolateral medulla mediates the depressor response elicited by the greater splanchnic nerve afferent stimulation in rats. Neurosci Lett. 2002 Jun 07; 325(2):134-8.
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Regional and postnatal heterogeneity of activity-dependent long-term changes in synaptic efficacy in the dorsal striatum. J Neurophysiol. 2000 Sep; 84(3):1422-9.
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Induction of locomotor sensitization by amphetamine requires the activation of NMDA receptors in the rat ventral tegmental area. Psychopharmacology (Berl). 2000 Aug; 151(2-3):184-91.
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Calcium influx through NMDA receptors directly evokes GABA release in olfactory bulb granule cells. J Neurosci. 2000 Jul 01; 20(13):5124-34.
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Regulation of vasopressin release by ionotropic glutamate receptor agonists. Adv Exp Med Biol. 1998; 449:129-30.
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Disrupted [Ca2+]i homeostasis contributes to the toxicity of nitric oxide in cultured hippocampal neurons. J Neurochem. 1997 Nov; 69(5):1882-9.
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Long-duration, frequency-dependent motor responses evoked by ventrolateral funiculus stimulation in the neonatal rat spinal cord. Neurosci Lett. 1995 Jun 09; 192(2):97-100.