 2-Amino-5-phosphonovalerate
"2-Amino-5-phosphonovalerate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Descriptor ID |
D015763
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| MeSH Number(s) |
D12.125.070.950.100 D12.125.740.025
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| Concept/Terms |
2-Amino-5-phosphonovalerate- 2-Amino-5-phosphonovalerate
- 2 Amino 5 phosphonovalerate
- 5-Phosphononorvaline
- 5 Phosphononorvaline
- 2-Amino-5-phosphonovaleric Acid
- 2 Amino 5 phosphonovaleric Acid
- 2-APV
- 2-Amino-5-phosphonopentanoate
- 2 Amino 5 phosphonopentanoate
- 2-Amino-5-phosphonopentanoic Acid
- 2 Amino 5 phosphonopentanoic Acid
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Below are MeSH descriptors whose meaning is more general than "2-Amino-5-phosphonovalerate".
Below are MeSH descriptors whose meaning is more specific than "2-Amino-5-phosphonovalerate".
This graph shows the total number of publications written about "2-Amino-5-phosphonovalerate" by people in this website by year, and whether "2-Amino-5-phosphonovalerate" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1987 | 0 | 1 | 1 | | 1988 | 0 | 1 | 1 | | 1989 | 0 | 1 | 1 | | 1990 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2000 | 0 | 3 | 3 | | 2005 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "2-Amino-5-phosphonovalerate" by people in Profiles.
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He Q, Titley H, Grasselli G, Piochon C, Hansel C. Ethanol affects NMDA receptor signaling at climbing fiber-Purkinje cell synapses in mice and impairs cerebellar LTD. J Neurophysiol. 2013 Mar; 109(5):1333-42.
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Cowley KC, Zaporozhets E, Maclean JN, Schmidt BJ. Is NMDA receptor activation essential for the production of locomotor-like activity in the neonatal rat spinal cord? J Neurophysiol. 2005 Dec; 94(6):3805-14.
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Partridge JG, Tang KC, Lovinger DM. Regional and postnatal heterogeneity of activity-dependent long-term changes in synaptic efficacy in the dorsal striatum. J Neurophysiol. 2000 Sep; 84(3):1422-9.
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Vezina P, Queen AL. Induction of locomotor sensitization by amphetamine requires the activation of NMDA receptors in the rat ventral tegmental area. Psychopharmacology (Berl). 2000 Aug; 151(2-3):184-91.
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Halabisky B, Friedman D, Radojicic M, Strowbridge BW. Calcium influx through NMDA receptors directly evokes GABA release in olfactory bulb granule cells. J Neurosci. 2000 Jul 01; 20(13):5124-34.
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Morsette DJ, Swenson KL, Badre SE, Sladek CD. Regulation of vasopressin release by ionotropic glutamate receptor agonists. Adv Exp Med Biol. 1998; 449:129-30.
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Brorson JR, Zhang H. Disrupted [Ca2+]i homeostasis contributes to the toxicity of nitric oxide in cultured hippocampal neurons. J Neurochem. 1997 Nov; 69(5):1882-9.
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Magnuson DS, Schramm MJ, MacLean JN. Long-duration, frequency-dependent motor responses evoked by ventrolateral funiculus stimulation in the neonatal rat spinal cord. Neurosci Lett. 1995 Jun 09; 192(2):97-100.
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Scharfman HE, Lu SM, Guido W, Adams PR, Sherman SM. N-methyl-D-aspartate receptors contribute to excitatory postsynaptic potentials of cat lateral geniculate neurons recorded in thalamic slices. Proc Natl Acad Sci U S A. 1990 Jun; 87(12):4548-52.
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Mitra J, Prabhakar NR, Overholt JL, Cherniack NS. Respiratory effects of N-methyl-D-aspartate on the ventrolateral medullary surface. J Appl Physiol (1985). 1989 Nov; 67(5):1814-9.
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