 Methacholine Chloride
"Methacholine Chloride" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
| Descriptor ID |
D016210
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| MeSH Number(s) |
D02.092.877.883.555.500 D02.675.276.534.500
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| Concept/Terms |
Methacholine Chloride- Methacholine Chloride
- Chloride, Methacholine
- Acetyl-2-methylcholine Chloride
- Acetyl 2 methylcholine Chloride
- Mecholine
- 2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium Chloride
- Acetyl-beta-methacholine Chloride
- Acetyl beta methacholine Chloride
Provocholine- Provocholine
- Roche Brand of Methacholine Chloride
- Methapharma Brand of Methacholine Chloride
Provokit- Provokit
- Lindopharm Brand of Methacholine Chloride
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Below are MeSH descriptors whose meaning is more general than "Methacholine Chloride".
Below are MeSH descriptors whose meaning is more specific than "Methacholine Chloride".
This graph shows the total number of publications written about "Methacholine Chloride" by people in this website by year, and whether "Methacholine Chloride" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1982 | 0 | 1 | 1 | | 1984 | 0 | 1 | 1 | | 1987 | 0 | 4 | 4 | | 1989 | 0 | 1 | 1 | | 1991 | 1 | 2 | 3 | | 1992 | 3 | 0 | 3 | | 1993 | 1 | 1 | 2 | | 1994 | 0 | 2 | 2 | | 1995 | 0 | 2 | 2 | | 1996 | 0 | 3 | 3 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 2 | 2 | | 2008 | 0 | 2 | 2 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Methacholine Chloride" by people in Profiles.
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Sharma P, Basu S, Mitchell RW, Stelmack GL, Anderson JE, Halayko AJ. Role of dystrophin in airway smooth muscle phenotype, contraction and lung function. PLoS One. 2014; 9(7):e102737.
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Alexander JT, El-Ali AM, Newman JL, Karatela S, Predmore BL, Lefer DJ, Sutliff RL, Roback JD. Red blood cells stored for increasing periods produce progressive impairments in nitric oxide-mediated vasodilation. Transfusion. 2013 Nov; 53(11):2619-2628.
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Sharma P, Ryu MH, Basu S, Maltby SA, Yeganeh B, Mutawe MM, Mitchell RW, Halayko AJ. Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase. Br J Pharmacol. 2012 Oct; 167(3):548-60.
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Brueggemann LI, Kakad PP, Love RB, Solway J, Dowell ML, Cribbs LL, Byron KL. Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy. . 2012 Jan 01; 302(1):L120-32.
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Lam YW, Sherman SM. Functional organization of the somatosensory cortical layer 6 feedback to the thalamus. Cereb Cortex. 2010 Jan; 20(1):13-24.
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Varela C, Sherman SM. Differences in response to serotonergic activation between first and higher order thalamic nuclei. Cereb Cortex. 2009 Aug; 19(8):1776-86.
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Pinto LH, Eaton E, Chen B, Fleisher J, Shuster D, McCauley J, Kedainis D, Siepka SM, Shimomura K, Song EJ, Husain A, Lakser OJ, Mitchell RW, Dowell ML, Brown M, Camoretti-Mercado B, Naclerio R, Sperling AI, Levin SI, Turek FW, Solway J. Gene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness. Mamm Genome. 2008 Jan; 19(1):2-14.
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Varela C, Sherman SM. Differences in response to muscarinic activation between first and higher order thalamic relays. J Neurophysiol. 2007 Dec; 98(6):3538-47.
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Muñoz NM, Meliton AY, Arm JP, Bonventre JV, Cho W, Leff AR. Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosensitized mice. J Immunol. 2007 Oct 01; 179(7):4800-7.
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Chen B, Liu G, Shardonofsky F, Dowell M, Lakser O, Mitchell RW, Fredberg JJ, Pinto LH, Solway J. Tidal breathing pattern differentially antagonizes bronchoconstriction in C57BL/6J vs. A/J mice. J Appl Physiol (1985). 2006 Jul; 101(1):249-55.
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