 CD4-Positive T-Lymphocytes
"CD4-Positive T-Lymphocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
| Descriptor ID |
D015496
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| MeSH Number(s) |
A11.118.637.555.567.569.200 A15.145.229.637.555.567.569.200 A15.382.490.555.567.569.200
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| Concept/Terms |
CD4-Positive T-Lymphocytes- CD4-Positive T-Lymphocytes
- CD4 Positive T Lymphocytes
- CD4-Positive T-Lymphocyte
- T-Lymphocyte, CD4-Positive
- T-Lymphocytes, CD4-Positive
- T4 Cells
- T4 Cell
- T4 Lymphocytes
- T4 Lymphocyte
- CD4-Positive Lymphocytes
- CD4-Positive Lymphocyte
- Lymphocyte, CD4-Positive
- Lymphocytes, CD4-Positive
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Below are MeSH descriptors whose meaning is more general than "CD4-Positive T-Lymphocytes".
Below are MeSH descriptors whose meaning is more specific than "CD4-Positive T-Lymphocytes".
This graph shows the total number of publications written about "CD4-Positive T-Lymphocytes" by people in this website by year, and whether "CD4-Positive T-Lymphocytes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1989 | 1 | 0 | 1 | | 1990 | 2 | 2 | 4 | | 1991 | 2 | 1 | 3 | | 1992 | 1 | 0 | 1 | | 1993 | 5 | 3 | 8 | | 1994 | 4 | 3 | 7 | | 1995 | 1 | 3 | 4 | | 1996 | 1 | 2 | 3 | | 1997 | 1 | 2 | 3 | | 1998 | 1 | 4 | 5 | | 1999 | 6 | 4 | 10 | | 2000 | 3 | 8 | 11 | | 2001 | 5 | 6 | 11 | | 2002 | 4 | 2 | 6 | | 2003 | 7 | 12 | 19 | | 2004 | 5 | 4 | 9 | | 2005 | 6 | 6 | 12 | | 2006 | 5 | 7 | 12 | | 2007 | 4 | 3 | 7 | | 2008 | 7 | 5 | 12 | | 2009 | 4 | 7 | 11 | | 2010 | 8 | 7 | 15 | | 2011 | 8 | 5 | 13 | | 2012 | 10 | 11 | 21 | | 2013 | 13 | 5 | 18 | | 2014 | 8 | 4 | 12 | | 2015 | 3 | 1 | 4 | | 2016 | 5 | 6 | 11 | | 2017 | 6 | 7 | 13 | | 2018 | 4 | 1 | 5 | | 2019 | 9 | 5 | 14 | | 2020 | 4 | 5 | 9 | | 2021 | 3 | 3 | 6 | | 2022 | 1 | 1 | 2 |
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Below are the most recent publications written about "CD4-Positive T-Lymphocytes" by people in Profiles.
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Malik A, Jabri B. Innate riddle of CD4+ T cells and the control of enteric infections. Immunity. 2022 07 12; 55(7):1145-1147.
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Andrade MS, Young JS, Pollard JM, Yin D, Alegre ML, Chong AS. Linked sensitization by memory CD4+ T cells prevents costimulation blockade-induced transplantation tolerance. JCI Insight. 2022 06 08; 7(11).
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Rogers D, Sood A, Wang H, van Beek JJP, Rademaker TJ, Artusa P, Schneider C, Shen C, Wong DC, Bhagrath A, Lebel MÈ, Condotta SA, Richer MJ, Martins AJ, Tsang JS, Barreiro LB, François P, Langlais D, Melichar HJ, Textor J, Mandl JN. Pre-existing chromatin accessibility and gene expression differences among naive CD4+ T cells influence effector potential. Cell Rep. 2021 11 30; 37(9):110064.
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Das S, Marin ND, Esaulova E, Ahmed M, Swain A, Rosa BA, Mitreva M, Rangel-Moreno J, Netea MG, Barreiro LB, Divangahi M, Artyomov MN, Kaushal D, Khader SA. Lung Epithelial Signaling Mediates Early Vaccine-Induced CD4+ T Cell Activation and Mycobacterium tuberculosis Control. mBio. 2021 08 31; 12(4):e0146821.
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Wong HS, Park K, Gola A, Baptista AP, Miller CH, Deep D, Lou M, Boyd LF, Rudensky AY, Savage PA, Altan-Bonnet G, Tsang JS, Germain RN. A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells. Cell. 2021 07 22; 184(15):3981-3997.e22.
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Rao E, Hou Y, Huang X, Wang L, Wang J, Zheng W, Yang H, Yu X, Yang K, Bugno J, Ding X, Vokes E, Fu YX, Weichselbaum RR, Liang HL. All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages. Sci Immunol. 2021 06 15; 6(60).
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Klawon DEJ, Gilmore DC, Leonard JD, Miller CH, Chao JL, Walker MT, Duncombe RK, Tung KS, Adams EJ, Savage PA. Altered selection on a single self-ligand promotes susceptibility to organ-specific T cell infiltration. J Exp Med. 2021 06 07; 218(6).
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Surette FA, Guthmiller JJ, Li L, Sturtz AJ, Vijay R, Pope RL, McClellan BL, Pack AD, Zander RA, Shao P, Lan LY, Fernandez-Ruiz D, Heath WR, Wilson PC, Butler NS. Extrafollicular CD4 T cell-derived IL-10 functions rapidly and transiently to support anti-Plasmodium humoral immunity. PLoS Pathog. 2021 02; 17(2):e1009288.
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Keller MD, Harris KM, Jensen-Wachspress MA, Kankate VV, Lang H, Lazarski CA, Durkee-Shock J, Lee PH, Chaudhry K, Webber K, Datar A, Terpilowski M, Reynolds EK, Stevenson EM, Val S, Shancer Z, Zhang N, Ulrey R, Ekanem U, Stanojevic M, Geiger A, Liang H, Hoq F, Abraham AA, Hanley PJ, Cruz CR, Ferrer K, Dropulic L, Gangler K, Burbelo PD, Jones RB, Cohen JI, Bollard CM. SARS-CoV-2-specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein. Blood. 2020 12 17; 136(25):2905-2917.
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El Bissati K, Zhou Y, Paulillo SM, Raman SK, Karch CP, Reed S, Estes A, Estes A, Lykins J, Burkhard P, McLeod R. Engineering and characterization of a novel Self Assembling Protein for Toxoplasma peptide vaccine in HLA-A*11:01, HLA-A*02:01 and HLA-B*07:02 transgenic mice. Sci Rep. 2020 10 12; 10(1):16984.
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