CD4-Positive T-Lymphocytes
"CD4-Positive T-Lymphocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
| Descriptor ID |
D015496
|
| MeSH Number(s) |
A11.118.637.555.567.569.200 A15.145.229.637.555.567.569.200 A15.382.490.555.567.569.200
|
| Concept/Terms |
CD4-Positive T-Lymphocytes- CD4-Positive T-Lymphocytes
- CD4 Positive T Lymphocytes
- CD4-Positive T-Lymphocyte
- T-Lymphocyte, CD4-Positive
- T-Lymphocytes, CD4-Positive
- CD4-Positive Lymphocytes
- CD4-Positive Lymphocyte
- Lymphocyte, CD4-Positive
- Lymphocytes, CD4-Positive
- T4 Cells
- T4 Cell
- T4 Lymphocytes
- T4 Lymphocyte
|
Below are MeSH descriptors whose meaning is more general than "CD4-Positive T-Lymphocytes".
Below are MeSH descriptors whose meaning is more specific than "CD4-Positive T-Lymphocytes".
This graph shows the total number of publications written about "CD4-Positive T-Lymphocytes" by people in this website by year, and whether "CD4-Positive T-Lymphocytes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 1997 | 1 | 3 | 4 |
| 1998 | 1 | 4 | 5 |
| 1999 | 6 | 4 | 10 |
| 2000 | 2 | 6 | 8 |
| 2001 | 5 | 6 | 11 |
| 2002 | 5 | 2 | 7 |
| 2003 | 6 | 11 | 17 |
| 2004 | 5 | 5 | 10 |
| 2005 | 5 | 7 | 12 |
| 2006 | 7 | 7 | 14 |
| 2007 | 5 | 3 | 8 |
| 2008 | 7 | 7 | 14 |
| 2009 | 6 | 9 | 15 |
| 2010 | 9 | 10 | 19 |
| 2011 | 8 | 6 | 14 |
| 2012 | 11 | 13 | 24 |
| 2013 | 15 | 7 | 22 |
| 2014 | 12 | 6 | 18 |
| 2015 | 5 | 1 | 6 |
| 2016 | 8 | 12 | 20 |
| 2017 | 6 | 8 | 14 |
| 2018 | 5 | 2 | 7 |
| 2019 | 11 | 6 | 17 |
| 2020 | 7 | 12 | 19 |
| 2021 | 6 | 6 | 12 |
| 2022 | 2 | 4 | 6 |
| 2023 | 7 | 4 | 11 |
| 2024 | 4 | 5 | 9 |
| 2025 | 9 | 2 | 11 |
| 2026 | 4 | 0 | 4 |
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Below are the most recent publications written about "CD4-Positive T-Lymphocytes" by people in Profiles.
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Post-COVID impairment of T cell responses to community-acquired pathogens can be modified by activating cellular metabolism. PLoS Pathog. 2026 07; 22(7):e1013860.
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Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprinting. Science. 2026 Jun 18; 392(6804):eaea4041.
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Tissue and CD4 T cell subset dependence on the amino acid transporter SLC38A1. Cell Metab. 2026 Apr 07; 38(4):712-728.e6.
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Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis. Nat Immunol. 2026 Feb; 27(2):236-249.
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Concurrent TB and HIV therapies control TB reactivation during co-infection but not chronic immune activation. Nat Commun. 2025 Dec 12; 17(1):499.
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Prediction and characterization of genetically regulated expression of asthma tissues from African-ancestry populations. J Allergy Clin Immunol. 2026 01; 157(1):253-261.
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Cell-intrinsic CD4 T cell tolerance: a new frontier in therapy? Trends Immunol. 2025 09; 46(9):624-634.
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Neuropilin-2 functions as a coinhibitory receptor to regulate antigen-induced inflammation and allograft rejection. J Clin Invest. 2025 07 01; 135(13).
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Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation. Nature. 2025 07; 643(8071):509-518.
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Mutant p53-specific CD8TCR-therapy combined with a CD4TCR prevents relapse of cancer and outgrowth of micrometastases. Oncoimmunology. 2025 Dec; 14(1):2514041.