The Werner's syndrome 4330T>C (Cys1367Arg) gene variant does not affect the in vitro cytotoxicity of topoisomerase inhibitors and platinum compounds.
Innocenti F, Mirkov S, Nagasubramanian R, Ram?rez J, Liu W, Bleibel WK, Shukla SJ, Hennessy K, Rosner GL, Cook E, Eileen Dolan M, Ratain MJ. The Werner's syndrome 4330T>C (Cys1367Arg) gene variant does not affect the in vitro cytotoxicity of topoisomerase inhibitors and platinum compounds. Cancer Chemother Pharmacol. 2009 Apr; 63(5):881-7.