"RecQ Helicases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of structurally-related DNA helicases that play an essential role in the maintenance of genome integrity. RecQ helicases were originally discovered in E COLI and are highly conserved across both prokaryotic and eukaryotic organisms. Genetic mutations that result in loss of RecQ helicase activity gives rise to disorders that are associated with CANCER predisposition and premature aging.
| Descriptor ID |
D053484
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| MeSH Number(s) |
D08.811.277.040.025.159.249 D08.811.399.340.249
|
| Concept/Terms |
RecQ Helicases- RecQ Helicases
- Helicases, RecQ
- RecQ Protein
- RecQ Family of DNA Helicases
RecQL Helicase- RecQL Helicase
- Helicase, RecQL
- RECQL1 Helicase
- Helicase, RECQL1
- DNA Helicase RecQL
- DNA-Dependent ATPase Q1
- DNA Dependent ATPase Q1
- ATP-Dependent DNA Helicase Q1
- ATP Dependent DNA Helicase Q1
- DNA Helicase Q1
RecQ4 Helicase- RecQ4 Helicase
- RTS Helicase
- Helicase, RTS
- RecQL4 Helicase
- Helicase, RecQL4
- ATP-Dependent DNA Helicase Q4
- ATP Dependent DNA Helicase Q4
- DNA Helicase RecQL4
RecQ5 Helicase- RecQ5 Helicase
- Helicase, RecQ5
- RecQ5L Helicase
- Helicase, RecQ5L
- ATP-Dependent DNA Helicase Q5
- ATP Dependent DNA Helicase Q5
RecQ2 Helicase- RecQ2 Helicase
- Helicase, RecQ2
- RecQL3 Helicase
- Helicase, RecQL3
- DNA Helicase, RecQ-like type 2
- DNA Helicase, RecQ like type 2
RecQ3 Helicase- RecQ3 Helicase
- Helicase, RecQ3
- RecQL2 Helicase
- Helicase, RecQL2
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Below are MeSH descriptors whose meaning is more general than "RecQ Helicases".
Below are MeSH descriptors whose meaning is more specific than "RecQ Helicases".
This graph shows the total number of publications written about "RecQ Helicases" by people in this website by year, and whether "RecQ Helicases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "RecQ Helicases" by people in Profiles.
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DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast. DNA Repair (Amst). 2013 Sep; 12(9):751-60.
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The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation. Carcinogenesis. 2012 Jun; 33(6):1203-10.
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Trex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repair. Genetics. 2011 Aug; 188(4):787-97.
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SUMO modification regulates BLM and RAD51 interaction at damaged replication forks. PLoS Biol. 2009 Dec; 7(12):e1000252.
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Loss of Bloom syndrome protein destabilizes human gene cluster architecture. Hum Mol Genet. 2009 Sep 15; 18(18):3417-28.
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The Werner's syndrome 4330T>C (Cys1367Arg) gene variant does not affect the in vitro cytotoxicity of topoisomerase inhibitors and platinum compounds. Cancer Chemother Pharmacol. 2009 Apr; 63(5):881-7.
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Osteosarcoma development and stem cell differentiation. Clin Orthop Relat Res. 2008 Sep; 466(9):2114-30.
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The broken genome: genetic and pharmacologic approaches to breaking DNA. Ann Med. 2007; 39(3):208-18.
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The Rothmund-Thomson gene product RECQL4 localizes to the nucleolus in response to oxidative stress. Exp Cell Res. 2006 Oct 15; 312(17):3443-57.
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Enhanced gene targeting efficiency by siRNA that silences the expression of the Bloom syndrome gene in human cells. Genes Cells. 2006 Apr; 11(4):363-71.