 Profilins
"Profilins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of low molecular weight proteins that bind ACTIN and control actin polymerization. They are found in eukaryotes and are ubiquitously expressed.
| Descriptor ID |
D051304
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| MeSH Number(s) |
D05.750.078.730.637 D12.776.210.500.775 D12.776.220.525.637
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Profilins".
Below are MeSH descriptors whose meaning is more specific than "Profilins".
This graph shows the total number of publications written about "Profilins" by people in this website by year, and whether "Profilins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 2000 | 0 | 3 | 3 | | 2001 | 0 | 2 | 2 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 2 | 2 | | 2005 | 0 | 2 | 2 | | 2006 | 2 | 0 | 2 | | 2008 | 1 | 1 | 2 | | 2011 | 0 | 2 | 2 | | 2013 | 0 | 2 | 2 | | 2014 | 3 | 0 | 3 | | 2019 | 1 | 1 | 2 |
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Below are the most recent publications written about "Profilins" by people in Profiles.
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Christensen JR, Craig EW, Glista MJ, Mueller DM, Li Y, Sees JA, Huang S, Suarez C, Mets LJ, Kovar DR, Avasthi P. Chlamydomonas reinhardtii formin FOR1 and profilin PRF1 are optimized for acute rapid actin filament assembly. Mol Biol Cell. 2019 12 15; 30(26):3123-3135.
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McCall PM, MacKintosh FC, Kovar DR, Gardel ML. Cofilin drives rapid turnover and fluidization of entangled F-actin. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):12629-12637.
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Rotty JD, Wu C, Haynes EM, Suarez C, Winkelman JD, Johnson HE, Haugh JM, Kovar DR, Bear JE. Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways. Dev Cell. 2015 Jan 12; 32(1):54-67.
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Suarez C, Carroll RT, Burke TA, Christensen JR, Bestul AJ, Sees JA, James ML, Sirotkin V, Kovar DR. Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex. Dev Cell. 2015 Jan 12; 32(1):43-53.
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Bestul AJ, Christensen JR, Grzegorzewska AP, Burke TA, Sees JA, Carroll RT, Sirotkin V, Keenan RJ, Kovar DR. Fission yeast profilin is tailored to facilitate actin assembly by the cytokinesis formin Cdc12. Mol Biol Cell. 2015 Jan 15; 26(2):283-93.
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Madasu Y, Suarez C, Kast DJ, Kovar DR, Dominguez R. Rickettsia Sca2 has evolved formin-like activity through a different molecular mechanism. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):E2677-86.
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Falzone TT, Oakes PW, Sees J, Kovar DR, Gardel ML. Actin assembly factors regulate the gelation kinetics and architecture of F-actin networks. Biophys J. 2013 Apr 16; 104(8):1709-19.
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Namgoong S, Boczkowska M, Glista MJ, Winkelman JD, Rebowski G, Kovar DR, Dominguez R. Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem W domain nucleation. Nat Struct Mol Biol. 2011 Aug 28; 18(9):1060-7.
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Scott BJ, Neidt EM, Kovar DR. The functionally distinct fission yeast formins have specific actin-assembly properties. Mol Biol Cell. 2011 Oct; 22(20):3826-39.
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Ezezika OC, Younger NS, Lu J, Kaiser DA, Corbin ZA, Nolen BJ, Kovar DR, Pollard TD. Incompatibility with formin Cdc12p prevents human profilin from substituting for fission yeast profilin: insights from crystal structures of fission yeast profilin. J Biol Chem. 2009 Jan 23; 284(4):2088-97.
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