"Cortactin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A microfilament protein that interacts with F-ACTIN and regulates cortical actin assembly and organization. It is also an SH3 DOMAIN containing phosphoprotein, and it mediates tyrosine PHOSPHORYLATION based SIGNAL TRANSDUCTION by PROTO-ONCOGENE PROTEIN PP60(C-SRC).
| Descriptor ID |
D051356
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| MeSH Number(s) |
D05.750.078.730.281 D12.644.360.024.280 D12.776.157.057.014 D12.776.220.525.281 D12.776.476.024.311 D12.776.744.390
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cortactin".
Below are MeSH descriptors whose meaning is more specific than "Cortactin".
This graph shows the total number of publications written about "Cortactin" by people in this website by year, and whether "Cortactin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cortactin" by people in Profiles.
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An Actin-, Cortactin- and Ena-VASP-Linked Complex Contributes to Endothelial Cell Focal Adhesion and Vascular Barrier Regulation. Cell Physiol Biochem. 2022 Jul 20; 56(4):329-339.
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Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination. Nat Commun. 2018 03 13; 9(1):1053.
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Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium. J Biol Chem. 2016 12 30; 291(53):27187-27203.
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PDCD10 (CCM3) regulates brain endothelial barrier integrity in cerebral cavernous malformation type 3: role of CCM3-ERK1/2-cortactin cross-talk. Acta Neuropathol. 2015 Nov; 130(5):731-50.
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IQGAP1 regulates endothelial barrier function via EB1-cortactin cross talk. Mol Cell Biol. 2014 Sep 15; 34(18):3546-58.
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Novel role for non-muscle myosin light chain kinase (MLCK) in hyperoxia-induced recruitment of cytoskeletal proteins, NADPH oxidase activation, and reactive oxygen species generation in lung endothelium. J Biol Chem. 2012 Mar 16; 287(12):9360-75.
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An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers. Hum Mol Genet. 2012 Apr 01; 21(7):1470-80.
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Phosphotyrosine protein dynamics in cell membrane rafts of sphingosine-1-phosphate-stimulated human endothelium: role in barrier enhancement. Cell Signal. 2009 Dec; 21(12):1945-60.
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A common cortactin gene variation confers differential susceptibility to severe asthma. Genet Epidemiol. 2008 Dec; 32(8):757-66.
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Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin. Biophys J. 2008 Jul; 95(2):886-94.