"Fenclonine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
| Descriptor ID |
D010134
|
| MeSH Number(s) |
D12.125.072.050.685.440
|
| Concept/Terms |
Fenclonine- Fenclonine
- para-Chlorophenylalanine
- para Chlorophenylalanine
- p-Chlorophenylalanine
- DL-3-(4-Chlorophenyl)alanine
- Fenclonin
|
Below are MeSH descriptors whose meaning is more general than "Fenclonine".
Below are MeSH descriptors whose meaning is more specific than "Fenclonine".
This graph shows the total number of publications written about "Fenclonine" by people in this website by year, and whether "Fenclonine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
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Below are the most recent publications written about "Fenclonine" by people in Profiles.
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p-Chlorophenylalanine and fluoxetine inhibit D-fenfluramine-induced Fos expression in the paraventricular nucleus, cingulate cortex and frontal cortex but not in other forebrain and brainstem regions. Brain Res. 1997 Nov 07; 774(1-2):94-105.
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Interaction between norepinephrine and serotonin in the neuroendocrine control of growth hormone release in the rat. Endocrinology. 1990 Feb; 126(2):1022-30.
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Excitatory effects of 5-hydroxytryptamine in the hippocampal-septal circuit. Brain Res. 1973 Aug 17; 58(1):245-50.