 Pentose Phosphate Pathway
"Pentose Phosphate Pathway" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An oxidative decarboxylation process that converts GLUCOSE-6-PHOSPHATE to D-ribose-5-phosphate via 6-phosphogluconate. The pentose product is used in the biosynthesis of NUCLEIC ACIDS. The generated energy is stored in the form of NADPH. This pathway is prominent in tissues which are active in the synthesis of FATTY ACIDS and STEROIDS.
| Descriptor ID |
D010427
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| MeSH Number(s) |
G02.111.087.160.875 G02.149.115.160.875 G03.495.256.875 G03.495.335.693 G03.495.553.695
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| Concept/Terms |
Pentose Phosphate Pathway- Pentose Phosphate Pathway
- Pathway, Pentose Phosphate
- Pathways, Pentose Phosphate
- Pentose Phosphate Pathways
- Pentose Phosphate Shunt
- Pentose Phosphate Shunts
- Shunt, Pentose Phosphate
- Shunts, Pentose Phosphate
- Pentose Shunt
- Pentose Shunts
- Shunt, Pentose
- Shunts, Pentose
- Pentose-Phosphate Pathway
- Pathway, Pentose-Phosphate
- Pathways, Pentose-Phosphate
- Pentose-Phosphate Pathways
- Pentosephosphate Shunt
- Pentosephosphate Shunts
- Shunt, Pentosephosphate
- Shunts, Pentosephosphate
- Hexose Monophosphate Shunt
- Hexose Monophosphate Shunts
- Shunt, Hexose Monophosphate
- Shunts, Hexose Monophosphate
- Pentosephosphate Pathway
- Pathway, Pentosephosphate
- Pathways, Pentosephosphate
- Pentosephosphate Pathways
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Below are MeSH descriptors whose meaning is more general than "Pentose Phosphate Pathway".
Below are MeSH descriptors whose meaning is more specific than "Pentose Phosphate Pathway".
This graph shows the total number of publications written about "Pentose Phosphate Pathway" by people in this website by year, and whether "Pentose Phosphate Pathway" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 | | 2015 | 1 | 1 | 2 | | 2016 | 1 | 1 | 2 | | 2018 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pentose Phosphate Pathway" by people in Profiles.
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Gao X, Zhao L, Liu S, Li Y, Xia S, Chen D, Wang M, Wu S, Dai Q, Vu H, Zacharias L, DeBerardinis R, Lim E, Metallo C, Boggon TJ, Lonial S, Lin R, Mao H, Pan Y, Shan C, Chen J. ?-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. Mol Cell. 2019 12 19; 76(6):857-871.e9.
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Xiao G, Chan LN, Klemm L, Braas D, Chen Z, Geng H, Zhang QC, Aghajanirefah A, Cosgun KN, Sadras T, Lee J, Mirzapoiazova T, Salgia R, Ernst T, Hochhaus A, Jumaa H, Jiang X, Weinstock DM, Graeber TG, Müschen M. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 2018 04 05; 173(2):470-484.e18.
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Elf S, Lin R, Xia S, Pan Y, Shan C, Wu S, Lonial S, Gaddh M, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Boggon TJ, Fan J, Chen J. Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin. Oncogene. 2017 01 12; 36(2):254-262.
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Debeb BG, Lacerda L, Larson R, Wolfe AR, Krishnamurthy S, Reuben JM, Ueno NT, Gilcrease M, Woodward WA. Histone deacetylase inhibitor-induced cancer stem cells exhibit high pentose phosphate pathway metabolism. Oncotarget. 2016 May 10; 7(19):28329-39.
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Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov; 17(11):1484-96.
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Litchfield LM, Mukherjee A, Eckert MA, Johnson A, Mills KA, Pan S, Shridhar V, Lengyel E, Romero IL. Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer. Oncotarget. 2015 Sep 15; 6(27):23548-60.
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Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu GM, Budinger GR, Chandel NS. Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8788-93.
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