 Siderophores
"Siderophores" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)
| Descriptor ID |
D017262
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| MeSH Number(s) |
D27.505.519.249.410.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Siderophores".
Below are MeSH descriptors whose meaning is more specific than "Siderophores".
This graph shows the total number of publications written about "Siderophores" by people in this website by year, and whether "Siderophores" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 | | 2007 | 1 | 1 | 2 | | 2008 | 3 | 0 | 3 | | 2011 | 1 | 2 | 3 | | 2012 | 1 | 1 | 2 | | 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Siderophores" by people in Profiles.
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Neres J, Engelhart CA, Drake EJ, Wilson DJ, Fu P, Boshoff HI, Barry CE, Gulick AM, Aldrich CC. Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii. J Med Chem. 2013 Mar 28; 56(6):2385-405.
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Duckworth BP, Wilson DJ, Nelson KM, Boshoff HI, Barry CE, Aldrich CC. Development of a selective activity-based probe for adenylating enzymes: profiling MbtA Involved in siderophore biosynthesis from Mycobacterium tuberculosis. ACS Chem Biol. 2012 Oct 19; 7(10):1653-8.
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Deng X, Sun F, Ji Q, Liang H, Missiakas D, Lan L, He C. Expression of multidrug resistance efflux pump gene norA is iron responsive in Staphylococcus aureus. J Bacteriol. 2012 Apr; 194(7):1753-62.
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Yuan G, Khan SA, Luo W, Nanduri J, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia. J Cell Physiol. 2011 Nov; 226(11):2925-33.
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Romanowski K, Zaborin A, Fernandez H, Poroyko V, Valuckaite V, Gerdes S, Liu DC, Zaborina OY, Alverdy JC. Prevention of siderophore- mediated gut-derived sepsis due to P. aeruginosa can be achieved without iron provision by maintaining local phosphate abundance: role of pH. BMC Microbiol. 2011 Sep 26; 11:212.
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Garcia AJ, Khan SA, Kumar GK, Prabhakar NR, Ramirez JM. Hydrogen peroxide differentially affects activity in the pre-Bötzinger complex and hippocampus. J Neurophysiol. 2011 Dec; 106(6):3045-55.
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Gupte A, Boshoff HI, Wilson DJ, Neres J, Labello NP, Somu RV, Xing C, Barry CE, Aldrich CC. Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosis. J Med Chem. 2008 Dec 11; 51(23):7495-507.
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Neres J, Wilson DJ, Celia L, Beck BJ, Aldrich CC. Aryl acid adenylating enzymes involved in siderophore biosynthesis: fluorescence polarization assay, ligand specificity, and discovery of non-nucleoside inhibitors via high-throughput screening. Biochemistry. 2008 Nov 11; 47(45):11735-49.
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Neres J, Labello NP, Somu RV, Boshoff HI, Wilson DJ, Vannada J, Chen L, Barry CE, Bennett EM, Aldrich CC. Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine. J Med Chem. 2008 Sep 11; 51(17):5349-70.
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Qiao C, Gupte A, Boshoff HI, Wilson DJ, Bennett EM, Somu RV, Barry CE, Aldrich CC. 5'-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: an adenylation enzyme required for siderophore biosynthesis of the mycobactins. J Med Chem. 2007 Nov 29; 50(24):6080-94.
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