"Iron Chelating Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.
| Descriptor ID |
D007502
|
| MeSH Number(s) |
D27.505.519.914.500.410 D27.720.832.500.410
|
| Concept/Terms |
Iron Chelating Agents- Iron Chelating Agents
- Agents, Iron Chelating
- Chelating Agents, Iron
- Iron Chelates
- Chelates, Iron
|
Below are MeSH descriptors whose meaning is more general than "Iron Chelating Agents".
Below are MeSH descriptors whose meaning is more specific than "Iron Chelating Agents".
This graph shows the total number of publications written about "Iron Chelating Agents" by people in this website by year, and whether "Iron Chelating Agents" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 0 | 2 | 2 |
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Below are the most recent publications written about "Iron Chelating Agents" by people in Profiles.
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Evidence that phosphorylation of iron regulatory protein 1 at Serine 138 destabilizes the [4Fe-4S] cluster in cytosolic aconitase by enhancing 4Fe-3Fe cycling. J Biol Chem. 2009 May 08; 284(19):12701-9.
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The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells. Cancer Res. 2009 Feb 01; 69(3):948-57.
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Asbestos causes apoptosis in alveolar epithelial cells: role of iron-induced free radicals. J Lab Clin Med. 2001 May; 137(5):330-9.
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Oxidants potentiate Ca(2+)- and cAMP-stimulated Cl(-) secretion in intestinal epithelial T84 cells. Gastroenterology. 2001 Jan; 120(1):89-98.
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Evidence of enhanced iron excretion during systemic phosphorothioate oligodeoxynucleotide treatment. J Toxicol Clin Toxicol. 2000; 38(4):383-7.
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Spin trapping of nitric oxide by ferro-chelates: kinetic and in vivo pharmacokinetic studies. Biochim Biophys Acta. 1999 Apr 19; 1427(2):216-26.
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Long-term assessment of efficacy and safety of L1, an oral iron chelator, in transfusion dependent thalassaemia: Indian trial. Br J Haematol. 1992 Oct; 82(2):460-6.