Peptide Elongation Factor 2
"Peptide Elongation Factor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Peptide Elongation Factor 2 catalyzes the translocation of peptidyl-tRNA from the A site to the P site of eukaryotic ribosomes by a process linked to the hydrolysis of GTP to GDP.
| Descriptor ID |
D020652
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| MeSH Number(s) |
D08.811.277.040.330.300.100.102 D12.776.157.325.150.102 D12.776.835.700.350.102
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Peptide Elongation Factor 2".
Below are MeSH descriptors whose meaning is more specific than "Peptide Elongation Factor 2".
This graph shows the total number of publications written about "Peptide Elongation Factor 2" by people in this website by year, and whether "Peptide Elongation Factor 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 0 | 2 | 2 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Peptide Elongation Factor 2" by people in Profiles.
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Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway. Proc Natl Acad Sci U S A. 2021 09 14; 118(37).
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Dph3 Enables Aerobic Diphthamide Biosynthesis by Donating One Iron Atom to Transform a [3Fe-4S] to a [4Fe-4S] Cluster in Dph1-Dph2. J Am Chem Soc. 2021 06 30; 143(25):9314-9319.
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The Crystal Structure of Dph2 in Complex with Elongation Factor 2 Reveals the Structural Basis for the First Step of Diphthamide Biosynthesis. Biochemistry. 2019 10 29; 58(43):4343-4351.
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Methods for Studying the Radical SAM Enzymes in Diphthamide Biosynthesis. Methods Enzymol. 2018; 606:421-438.
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The biosynthesis and biological function of diphthamide. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48(6):515-21.
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The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell. 2013 May 23; 153(5):1064-79.
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Reconstitution of diphthine synthase activity in vitro. Biochemistry. 2010 Nov 09; 49(44):9649-57.
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Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD. Biochemistry. 2009 Apr 07; 48(13):2878-90.
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Glucose regulates EF-2 phosphorylation and protein translation by a protein phosphatase-2A-dependent mechanism in INS-1-derived 832/13 cells. J Biol Chem. 2003 May 16; 278(20):18177-83.
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Ribosomes terminated in vitro are in a tight association with non-phosphorylated elongation factor 2 (eEF-2) and GDP. Eur J Biochem. 1993 Jul 15; 215(2):291-6.