Peptide Elongation Factor 2
"Peptide Elongation Factor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Peptide Elongation Factor 2 catalyzes the translocation of peptidyl-tRNA from the A site to the P site of eukaryotic ribosomes by a process linked to the hydrolysis of GTP to GDP.
| Descriptor ID |
D020652
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| MeSH Number(s) |
D08.811.277.040.330.300.100.102 D12.776.157.325.150.102 D12.776.835.700.350.102
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Peptide Elongation Factor 2".
Below are MeSH descriptors whose meaning is more specific than "Peptide Elongation Factor 2".
This graph shows the total number of publications written about "Peptide Elongation Factor 2" by people in this website by year, and whether "Peptide Elongation Factor 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Peptide Elongation Factor 2" by people in Profiles.
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The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell. 2013 May 23; 153(5):1064-79.
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Glucose regulates EF-2 phosphorylation and protein translation by a protein phosphatase-2A-dependent mechanism in INS-1-derived 832/13 cells. J Biol Chem. 2003 May 16; 278(20):18177-83.
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Ribosomes terminated in vitro are in a tight association with non-phosphorylated elongation factor 2 (eEF-2) and GDP. Eur J Biochem. 1993 Jul 15; 215(2):291-6.
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ADP-ribosylated elongation factor 2 (ADP-ribosyl-EF-2) is unable to promote translocation within the ribosome. FEBS Lett. 1990 Feb 26; 261(2):350-2.
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Eukaryotic elongation factor 2 loses its non-specific affinity for RNA and leaves polyribosomes as a result of ADP-ribosylation. FEBS Lett. 1984 Oct 29; 176(2):406-10.
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Endogenous ADP-ribosylation of elongation factor 2 in polyribosome fraction of rabbit reticulocytes. FEBS Lett. 1984 Oct 15; 176(1):261-3.