 Genetic Pleiotropy
"Genetic Pleiotropy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phenomenon in which multiple and diverse phenotypic outcomes are influenced by a single gene (or single gene product.)
| Descriptor ID |
D058685
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| MeSH Number(s) |
G05.420.556 G05.695.550
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| Concept/Terms |
Genetic Pleiotropy- Genetic Pleiotropy
- Pleiotropy, Genetic
- Genetic Pleiotropism
- Pleiotropism, Genetic
Pleiotropic Gene- Pleiotropic Gene
- Gene, Pleiotropic
- Genes, Pleiotropic
- Pleiotropic Genes
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Below are MeSH descriptors whose meaning is more general than "Genetic Pleiotropy".
Below are MeSH descriptors whose meaning is more specific than "Genetic Pleiotropy".
This graph shows the total number of publications written about "Genetic Pleiotropy" by people in this website by year, and whether "Genetic Pleiotropy" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 3 | 3 | | 2013 | 0 | 1 | 1 | | 2014 | 2 | 0 | 2 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 1 | 2 | | 2017 | 2 | 0 | 2 | | 2018 | 1 | 1 | 2 | | 2020 | 3 | 0 | 3 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Genetic Pleiotropy" by people in Profiles.
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Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T, Havulinna AS, Pirruccello JP, Qian J, Shcherbina A. Genetics of 35 blood and urine biomarkers in the UK Biobank. Nat Genet. 2021 02; 53(2):185-194.
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Gleason KJ, Yang F, Pierce BL, He X, Chen LS. Primo: integration of multiple GWAS and omics QTL summary statistics for elucidation of molecular mechanisms of trait-associated SNPs and detection of pleiotropy in complex traits. Genome Biol. 2020 09 11; 21(1):236.
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Kawai VK, Shi M, Feng Q, Chung CP, Liu G, Cox NJ, Jarvik GP, Lee MTM, Hebbring SJ, Harley JB, Kaufman KM, Namjou B, Larson E, Gordon AS, Roden DM, Stein CM, Mosley JD. Pleiotropy in the Genetic Predisposition to Rheumatoid Arthritis: A Phenome-Wide Association Study and Inverse Variance-Weighted Meta-Analysis. Arthritis Rheumatol. 2020 09; 72(9):1483-1492.
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Morrison J, Knoblauch N, Marcus JH, Stephens M, He X. Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics. Nat Genet. 2020 07; 52(7):740-747.
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Diogo D, Tian C, Franklin CS, Alanne-Kinnunen M, March M, Spencer CCA, Vangjeli C, Weale ME, Mattsson H, Kilpeläinen E, Sleiman PMA, Reilly DF, McElwee J, Maranville JC, Chatterjee AK, Bhandari A, Nguyen KH, Estrada K, Reeve MP, Hutz J, Bing N, John S, MacArthur DG, Salomaa V, Ripatti S, Hakonarson H, Daly MJ, Palotie A, Hinds DA, Donnelly P, Fox CS, Day-Williams AG, Plenge RM, Runz H. Phenome-wide association studies across large population cohorts support drug target validation. Nat Commun. 2018 10 16; 9(1):4285.
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Mika KM, Li X, DeMayo FJ, Lynch VJ. An Ancient Fecundability-Associated Polymorphism Creates a GATA2 Binding Site in a Distal Enhancer of HLA-F. Am J Hum Genet. 2018 10 04; 103(4):509-521.
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Meloto CB, Benavides R, Lichtenwalter RN, Wen X, Tugarinov N, Zorina-Lichtenwalter K, Chabot-Doré AJ, Piltonen MH, Cattaneo S, Verma V, Klares R, Khoury S, Parisien M, Diatchenko L. Human pain genetics database: a resource dedicated to human pain genetics research. Pain. 2018 04; 159(4):749-763.
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Frachon L, Libourel C, Villoutreix R, Carrère S, Glorieux C, Huard-Chauveau C, Navascués M, Gay L, Vitalis R, Baron E, Amsellem L, Bouchez O, Vidal M, Le Corre V, Roby D, Bergelson J, Roux F. Intermediate degrees of synergistic pleiotropy drive adaptive evolution in ecological time. Nat Ecol Evol. 2017 Oct; 1(10):1551-1561.
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Oesterle A, Laufs U, Liao JK. Pleiotropic Effects of Statins on the Cardiovascular System. Circ Res. 2017 Jan 06; 120(1):229-243.
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Neumann A, Pappa I, Lahey BB, Verhulst FC, Medina-Gomez C, Jaddoe VW, Bakermans-Kranenburg MJ, Moffitt TE, van IJzendoorn MH, Tiemeier H. Single Nucleotide Polymorphism Heritability of a General Psychopathology Factor in Children. J Am Acad Child Adolesc Psychiatry. 2016 12; 55(12):1038-1045.e4.
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