"Genetic Pleiotropy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phenomenon in which multiple and diverse phenotypic outcomes are influenced by a single gene (or single gene product.)
| Descriptor ID |
D058685
|
| MeSH Number(s) |
G05.420.556 G05.695.550
|
| Concept/Terms |
Genetic Pleiotropy- Genetic Pleiotropy
- Pleiotropy, Genetic
- Genetic Pleiotropism
- Pleiotropism, Genetic
Pleiotropic Gene- Pleiotropic Gene
- Gene, Pleiotropic
- Genes, Pleiotropic
- Pleiotropic Genes
|
Below are MeSH descriptors whose meaning is more general than "Genetic Pleiotropy".
Below are MeSH descriptors whose meaning is more specific than "Genetic Pleiotropy".
This graph shows the total number of publications written about "Genetic Pleiotropy" by people in this website by year, and whether "Genetic Pleiotropy" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 3 | 3 |
| 2013 | 0 | 1 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 1 | 2 |
| 2017 | 2 | 1 | 3 |
| 2018 | 1 | 1 | 2 |
| 2020 | 3 | 1 | 4 |
| 2021 | 1 | 2 | 3 |
| 2022 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Genetic Pleiotropy" by people in Profiles.
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JASPER: Fast, powerful, multitrait association testing in structured samples gives insight on pleiotropy in gene expression. Am J Hum Genet. 2024 Aug 08; 111(8):1750-1769.
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Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation. Elife. 2022 09 08; 11.
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A cross-population atlas of genetic associations for 220 human phenotypes. Nat Genet. 2021 10; 53(10):1415-1424.
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A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci. Nat Commun. 2021 09 06; 12(1):5253.
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Genetics of 35 blood and urine biomarkers in the UK Biobank. Nat Genet. 2021 02; 53(2):185-194.
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Primo: integration of multiple GWAS and omics QTL summary statistics for elucidation of molecular mechanisms of trait-associated SNPs and detection of pleiotropy in complex traits. Genome Biol. 2020 09 11; 21(1):236.
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Pleiotropy in the Genetic Predisposition to Rheumatoid Arthritis: A Phenome-Wide Association Study and Inverse Variance-Weighted Meta-Analysis. Arthritis Rheumatol. 2020 09; 72(9):1483-1492.
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Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics. Nat Genet. 2020 07; 52(7):740-747.
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Modular Organization of Cis-regulatory Control Information of Neurotransmitter Pathway Genes in Caenorhabditis elegans. Genetics. 2020 07; 215(3):665-681.
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Phenome-wide association studies across large population cohorts support drug target validation. Nat Commun. 2018 10 16; 9(1):4285.