"F-Box Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins that share the F-BOX MOTIF and are involved in protein-protein interactions. They play an important role in process of protein ubiquition by associating with a variety of substrates and then associating into SCF UBIQUITIN LIGASE complexes. They are held in the ubiquitin-ligase complex via binding to SKP DOMAIN PROTEINS.
| Descriptor ID |
D044783
|
| MeSH Number(s) |
D12.776.157.169
|
| Concept/Terms |
F-Box Proteins- F-Box Proteins
- F Box Proteins
- F-Box Domain Protein
- Domain Protein, F-Box
- F Box Domain Protein
- Protein, F-Box Domain
- F-Box Protein Family
- F Box Protein Family
- Protein Family, F-Box
|
Below are MeSH descriptors whose meaning is more general than "F-Box Proteins".
Below are MeSH descriptors whose meaning is more specific than "F-Box Proteins".
This graph shows the total number of publications written about "F-Box Proteins" by people in this website by year, and whether "F-Box Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 2 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "F-Box Proteins" by people in Profiles.
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Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulation. Mol Cell Biol. 2014 Sep; 34(17):3244-58.
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An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape. Dev Cell. 2013 Mar 11; 24(5):530-42.
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miR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia. Blood. 2012 Jul 12; 120(2):249-58.
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An integrated view of cyclin E function and regulation. Cell Cycle. 2012 Jan 01; 11(1):57-64.
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Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 2011 Aug 26; 333(6046):1154-7.
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Characterization of mouse Dactylaplasia mutations: a model for human ectrodactyly SHFM3. Mamm Genome. 2008 Apr; 19(4):272-8.
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hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53. Cancer Sci. 2003 May; 94(5):431-6.