Adaptor Proteins, Signal Transducing
"Adaptor Proteins, Signal Transducing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
| Descriptor ID |
D048868
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| MeSH Number(s) |
D12.644.360.024 D12.776.157.057 D12.776.476.024
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Adaptor Proteins, Signal Transducing".
Below are MeSH descriptors whose meaning is more specific than "Adaptor Proteins, Signal Transducing".
This graph shows the total number of publications written about "Adaptor Proteins, Signal Transducing" by people in this website by year, and whether "Adaptor Proteins, Signal Transducing" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 0 | 2 |
| 1996 | 4 | 0 | 4 |
| 1997 | 7 | 0 | 7 |
| 1998 | 3 | 0 | 3 |
| 1999 | 4 | 4 | 8 |
| 2000 | 2 | 2 | 4 |
| 2001 | 5 | 2 | 7 |
| 2002 | 8 | 3 | 11 |
| 2003 | 2 | 3 | 5 |
| 2004 | 5 | 3 | 8 |
| 2005 | 5 | 6 | 11 |
| 2006 | 3 | 9 | 12 |
| 2007 | 3 | 6 | 9 |
| 2008 | 5 | 2 | 7 |
| 2009 | 7 | 5 | 12 |
| 2010 | 9 | 7 | 16 |
| 2011 | 3 | 7 | 10 |
| 2012 | 3 | 7 | 10 |
| 2013 | 13 | 4 | 17 |
| 2014 | 8 | 12 | 20 |
| 2015 | 4 | 11 | 15 |
| 2016 | 3 | 5 | 8 |
| 2017 | 5 | 3 | 8 |
| 2018 | 5 | 2 | 7 |
| 2019 | 3 | 1 | 4 |
| 2020 | 4 | 3 | 7 |
| 2021 | 8 | 0 | 8 |
| 2022 | 1 | 2 | 3 |
| 2023 | 1 | 3 | 4 |
| 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "Adaptor Proteins, Signal Transducing" by people in Profiles.
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MAVS Cys508 palmitoylation promotes its aggregation on the mitochondrial outer membrane and antiviral innate immunity. Proc Natl Acad Sci U S A. 2024 Aug 20; 121(34):e2403392121.
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Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader. J Med Chem. 2024 May 09; 67(9):6938-6951.
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A genome-wide genetic screen uncovers determinants of human pigmentation. Science. 2023 08 11; 381(6658):eade6289.
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Germline Variants Incidentally Detected via Tumor-Only Genomic Profiling of Patients With Mesothelioma. JAMA Netw Open. 2023 08 01; 6(8):e2327351.
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Impact of prior therapies and subsequent transplantation on outcomes in adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia treated with brexucabtagene autoleucel in ZUMA-3. J Immunother Cancer. 2023 08; 11(8).
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Rare missense variants in the SH3 domain of PSTPIP1 are associated with hidradenitis suppurativa. HGG Adv. 2023 04 13; 4(2):100187.
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TLR4 activation induces inflammatory vascular permeability via Dock1 targeting and NOX4 upregulation. Biochim Biophys Acta Mol Basis Dis. 2022 12 01; 1868(12):166562.
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BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia. Mol Neurodegener. 2022 05 07; 17(1):33.
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Ablation of high-mobility group box-1 in the liver reduces hepatocellular carcinoma but causes hyperbilirubinemia in Hippo signaling-deficient mice. Hepatol Commun. 2022 08; 6(8):2155-2169.
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XB130 Plays an Essential Role in Folliculogenesis Through Mediating Interactions Between Microfilament and Microtubule Systems in Thyrocytes. Thyroid. 2022 02; 32(2):128-137.