 MAP Kinase Kinase 4
"MAP Kinase Kinase 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress.
| Descriptor ID |
D048670
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| MeSH Number(s) |
D08.811.913.696.620.682.700.565.400 D08.811.913.696.620.682.725.200.400 D12.644.360.440.400 D12.776.476.440.400
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| Concept/Terms |
MAP Kinase Kinase 4- MAP Kinase Kinase 4
- JNK Kinase
- JNK-Activating Protein Kinase
- JNK Activating Protein Kinase
- Protein Kinase, JNK-Activating
- JNKK1 Protein Kinase
- Kinase, JNKK1 Protein
- Protein Kinase, JNKK1
- Jun Amino-Terminal Kinase Kinase
- Jun Amino Terminal Kinase Kinase
- Stress-Activated Protein Kinase Kinase 1
- Stress Activated Protein Kinase Kinase 1
- Mitogen-Activated Protein Kinase Kinase 4
- Mitogen Activated Protein Kinase Kinase 4
- SAP Kinase Kinase 1
- SAP Kinase-Extracellular Signal-Regulated Kinase Kinase 1
- SAP Kinase Extracellular Signal Regulated Kinase Kinase 1
- SAPK-ERK Kinase 1
- SAPK ERK Kinase 1
- SEK1 Protein Kinase
- Protein Kinase, SEK1
- JN Kinase Kinase
- MEK4 Protein Kinase
- Protein Kinase, MEK4
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Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase 4".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase 4".
This graph shows the total number of publications written about "MAP Kinase Kinase 4" by people in this website by year, and whether "MAP Kinase Kinase 4" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 0 | 1 | 1 | | 1998 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 3 | 0 | 3 | | 2001 | 2 | 1 | 3 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2004 | 0 | 3 | 3 | | 2005 | 1 | 1 | 2 | | 2006 | 1 | 2 | 3 | | 2007 | 0 | 2 | 2 | | 2008 | 4 | 2 | 6 | | 2009 | 3 | 0 | 3 | | 2010 | 0 | 2 | 2 | | 2011 | 2 | 1 | 3 | | 2012 | 2 | 0 | 2 | | 2013 | 0 | 1 | 1 | | 2014 | 2 | 0 | 2 | | 2016 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "MAP Kinase Kinase 4" by people in Profiles.
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Sheng T, Sun Y, Sun J, Prinz RA, Peng D, Liu X, Xu X. Role of TGF-ß-activated kinase 1 (TAK1) activation in H5N1 influenza A virus-induced c-Jun terminal kinase activation and virus replication. Virology. 2019 11; 537:263-271.
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Sarikhani M, Mishra S, Desingu PA, Kotyada C, Wolfgeher D, Gupta MP, Singh M, Sundaresan NR. SIRT2 regulates oxidative stress-induced cell death through deacetylation of c-Jun NH2-terminal kinase. Cell Death Differ. 2018 09; 25(9):1638-1656.
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Zhang T, Sheng Z, Du W. Loss of histone deacetylase HDAC1 induces cell death in Drosophila epithelial cells through JNK and Hippo signaling. Mech Dev. 2016 08; 141:4-13.
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Hong Z, Cabrera JA, Mahapatra S, Kutty S, Weir EK, Archer SL. Activation of the EGFR/p38/JNK pathway by mitochondrial-derived hydrogen peroxide contributes to oxygen-induced contraction of ductus arteriosus. J Mol Med (Berl). 2014 Sep; 92(9):995-1007.
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Huang HH, Shao ZH, Li CQ, Vanden Hoek TL, Li J. Baicalein protects cardiomyocytes against mitochondrial oxidant injury associated with JNK inhibition and mitochondrial Akt activation. Am J Chin Med. 2014; 42(1):79-94.
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Gordon GM, Zhang T, Zhao J, Du W. Deregulated G1-S control and energy stress contribute to the synthetic-lethal interactions between inactivation of RB and TSC1 or TSC2. J Cell Sci. 2013 May 01; 126(Pt 9):2004-13.
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Krishnan V, Stadick N, Clark R, Bainer R, Veneris JT, Khan S, Drew A, Rinker-Schaeffer C. Using MKK4's metastasis suppressor function to identify and dissect cancer cell-microenvironment interactions during metastatic colonization. Cancer Metastasis Rev. 2012 Dec; 31(3-4):605-13.
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Bainer RO, Veneris JT, Yamada SD, Montag A, Lingen MW, Gilad Y, Rinker-Schaeffer CW. Time-dependent transcriptional profiling links gene expression to mitogen-activated protein kinase kinase 4 (MKK4)-mediated suppression of omental metastatic colonization. Clin Exp Metastasis. 2012 Jun; 29(5):397-408.
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Janardhan SV, Praveen K, Marks R, Gajewski TF. Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4+ T cells. PLoS One. 2011; 6(9):e24931.
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Knopeke MT, Ritschdorff ET, Clark R, Vander Griend DJ, Khan S, Thobe M, Shear JB, Rinker-Schaeffer CW. Building on the foundation of daring hypotheses: using the MKK4 metastasis suppressor to develop models of dormancy and metastatic colonization. FEBS Lett. 2011 Oct 20; 585(20):3159-65.
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