"MAP Kinase Kinase 7" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to CYTOKINES.
| Descriptor ID |
D048688
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| MeSH Number(s) |
D08.811.913.696.620.682.700.565.700 D08.811.913.696.620.682.725.200.700 D12.644.360.440.700 D12.776.476.440.700
|
| Concept/Terms |
MAP Kinase Kinase 7- MAP Kinase Kinase 7
- PRKMK7
- Mitogen-Activated Protein Kinase Kinase 7
- Mitogen Activated Protein Kinase Kinase 7
- MAPKK7 Protein Kinase
- Protein Kinase, MAPKK7
- MEK7 Protein Kinase
- Protein Kinase, MEK7
- SKK4 Protein Kinase
- Protein Kinase, SKK4
- JNK-Activating Kinase 2
- JNK Activating Kinase 2
- SEK2 Protein Kinase
- Protein Kinase, SEK2
|
Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase 7".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase 7".
This graph shows the total number of publications written about "MAP Kinase Kinase 7" by people in this website by year, and whether "MAP Kinase Kinase 7" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 2 | 2 |
| 2007 | 1 | 1 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "MAP Kinase Kinase 7" by people in Profiles.
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Probing the interaction interface of the GADD45ß/MKK7 and MKK7/DTP3 complexes by chemical cross-linking mass spectrometry. Int J Biol Macromol. 2018 Jul 15; 114:114-123.
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Novel TRAIL sensitizer Taraxacum officinale F.H. Wigg enhances TRAIL-induced apoptosis in Huh7 cells. Mol Carcinog. 2016 Apr; 55(4):387-96.
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Cancer-selective targeting of the NF-?B survival pathway with GADD45ß/MKK7 inhibitors. Cancer Cell. 2014 10 13; 26(4):495-508.
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Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling. Arthritis Rheum. 2009 Nov; 60(11):3229-40.
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Gadd45beta dimerization does not affect MKK7 binding. Adv Exp Med Biol. 2009; 611:367-8.
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Gadd45 beta forms a homodimeric complex that binds tightly to MKK7. J Mol Biol. 2008 Apr 18; 378(1):97-111.
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Up-regulation of MKK4, MKK6 and MKK7 during prostate cancer progression: an important role for SAPK signalling in prostatic neoplasia. J Pathol. 2007 Aug; 212(4):386-94.
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Insights into the structural basis of the GADD45beta-mediated inactivation of the JNK kinase, MKK7/JNKK2. J Biol Chem. 2007 Jun 29; 282(26):19029-41.
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Role of the JNK pathway in NMDA-mediated excitotoxicity of cortical neurons. Cell Death Differ. 2007 Feb; 14(2):240-53.
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The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma. Cancer Res. 2006 Feb 15; 66(4):2264-70.