 Receptors, Neurokinin-1
"Receptors, Neurokinin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of cell surface receptors for tachykinins with a preference for substance P. Neurokinin-1 (NK-1) receptors have been cloned and are members of the G protein coupled receptor superfamily. They are found on many cell types including central and peripheral neurons, smooth muscle cells, acinar cells, endothelial cells, fibroblasts, and immune cells.
| Descriptor ID |
D018040
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| MeSH Number(s) |
D12.776.543.750.720.600.830.500 D12.776.543.750.750.555.830.500
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| Concept/Terms |
Receptors, Neurokinin-1- Receptors, Neurokinin-1
- Receptors, Neurokinin 1
- Substance P Receptors
- P Receptors, Substance
- Receptors, Substance P
- NK-1 Receptor
- NK 1 Receptor
- Receptor, NK-1
- Receptors, NK-1
- Receptors, NK 1
- SP-P Receptors
- SP P Receptors
- Neurokinin-1 Receptor
- Neurokinin 1 Receptor
- Receptor, Neurokinin-1
- Neurokinin-1 Receptors
- Neurokinin 1 Receptors
- Receptors, SP-P
- Receptors, SP P
- SP-P Receptor
- Receptor, SP-P
- SP P Receptor
- Substance P Receptor
- P Receptor, Substance
- Receptor, Substance P
- NK-1 Receptors
- NK 1 Receptors
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Below are MeSH descriptors whose meaning is more general than "Receptors, Neurokinin-1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Neuropeptide [D12.776.543.750.720.600]
- Receptors, Tachykinin [D12.776.543.750.720.600.830]
- Receptors, Neurokinin-1 [D12.776.543.750.720.600.830.500]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Neuropeptide [D12.776.543.750.750.555]
- Receptors, Tachykinin [D12.776.543.750.750.555.830]
- Receptors, Neurokinin-1 [D12.776.543.750.750.555.830.500]
Below are MeSH descriptors whose meaning is more specific than "Receptors, Neurokinin-1".
This graph shows the total number of publications written about "Receptors, Neurokinin-1" by people in this website by year, and whether "Receptors, Neurokinin-1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptors, Neurokinin-1" by people in Profiles.
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Navari RM. HTX-019: polysorbate 80- and synthetic surfactant-free neurokinin 1 receptor antagonist for chemotherapy-induced nausea and vomiting prophylaxis. Future Oncol. 2019 Jan; 15(3):241-255.
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Navari RM. 5-HT3 receptors as important mediators of nausea and vomiting due to chemotherapy. Biochim Biophys Acta. 2015 Oct; 1848(10 Pt B):2738-46.
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Gozal D, Kim J, Bhattacharjee R, Goldman JL, Kheirandish-Gozal L. Substance P and neurokinin 1 receptors as potential therapeutic targets in children with OSA. Chest. 2014 May; 145(5):1039-1045.
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Doi A, Ramirez JM. State-dependent interactions between excitatory neuromodulators in the neuronal control of breathing. J Neurosci. 2010 Jun 16; 30(24):8251-62.
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Rizk SS, Luchniak A, Uysal S, Brawley CM, Rock RS, Kossiakoff AA. An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11011-5.
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Navari RM. Fosaprepitant: a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting. Expert Rev Anticancer Ther. 2008 Nov; 8(11):1733-42.
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Navari RM. Fosaprepitant (MK-0517): a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting. Expert Opin Investig Drugs. 2007 Dec; 16(12):1977-85.
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Goldbart AD, Mager E, Veling MC, Goldman JL, Kheirandish-Gozal L, Serpero LD, Piedimonte G, Gozal D. Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea. Pediatr Res. 2007 Oct; 62(4):489-94.
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Navari RM, Province PS. Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar; 11(1):137-51.
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Simeonidis S, Castagliuolo I, Pan A, Liu J, Wang CC, Mykoniatis A, Pasha A, Valenick L, Sougioultzis S, Zhao D, Pothoulakis C. Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-kappa B site on its promoter. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2957-62.
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