 Receptors, Adrenergic, alpha-2
"Receptors, Adrenergic, alpha-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.
| Descriptor ID |
D018341
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| MeSH Number(s) |
D12.776.543.750.070.300.300.300.725 D12.776.543.750.100.150.300.300.725 D12.776.543.750.720.300.300.300.300.200
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| Concept/Terms |
Receptors, Adrenergic, alpha-2- Receptors, Adrenergic, alpha-2
- Adrenergic Receptor, alpha-2
- Adrenergic Receptor, alpha 2
- Receptor, alpha-2 Adrenergic
- alpha-2 Adrenergic Receptor
- Receptors, alpha-2 Adrenergic
- Receptors, alpha 2 Adrenergic
- alpha-2 Adrenergic Receptors
- Adrenergic Receptors, alpha-2
- Receptor, Adrenergic, alpha-2
- Adrenergic alpha-2 Receptors
- Adrenergic alpha 2 Receptors
- Receptors, Adrenergic alpha-2
- alpha-2 Receptors, Adrenergic
- alpha 2 Adrenergic Receptors
Receptor, Adrenergic, alpha-2D- Receptor, Adrenergic, alpha-2D
- Receptors, Adrenergic, alpha-2D
- alpha-2D Adrenergic Receptor
- Adrenergic Receptor, alpha-2D
- Receptor, alpha-2D Adrenergic
- alpha 2D Adrenergic Receptor
- Adrenergic alpha-2D Receptors
- Adrenergic alpha 2D Receptors
- Receptors, Adrenergic alpha-2D
- alpha-2D Receptors, Adrenergic
- Adrenergic Receptor alpha(2d)
Receptor, Adrenergic, alpha-2C- Receptor, Adrenergic, alpha-2C
- alpha-2C Adrenergic Receptor
- Adrenergic Receptor, alpha-2C
- Receptor, alpha-2C Adrenergic
- alpha 2C Adrenergic Receptor
- Adrenergic Receptor alpha-2C
- Adrenergic Receptor alpha 2C
- Receptor alpha-2C, Adrenergic
- alpha-2C, Adrenergic Receptor
- Adrenergic alpha-2C Receptors
- Adrenergic alpha 2C Receptors
- Receptors, Adrenergic alpha-2C
- alpha-2C Receptors, Adrenergic
- Adrenergic Receptor alpha(2C)
Receptor, Adrenergic, alpha-2A- Receptor, Adrenergic, alpha-2A
- alpha-2A Adrenergic Receptor
- Adrenergic Receptor, alpha-2A
- Receptor, alpha-2A Adrenergic
- alpha 2A Adrenergic Receptor
- Receptors, Adrenergic, alpha-2A
- Adrenergic alpha-2A Receptors
- Adrenergic alpha 2A Receptors
- Receptors, Adrenergic alpha-2A
- alpha-2A Receptors, Adrenergic
Receptor, Adrenergic, alpha-2B- Receptor, Adrenergic, alpha-2B
- Receptors, Adrenergic, alpha-2B
- alpha-2B Adrenergic Receptor
- Adrenergic Receptor, alpha-2B
- Receptor, alpha-2B Adrenergic
- alpha 2B Adrenergic Receptor
- Adrenergic alpha-2B Receptors
- Adrenergic alpha 2B Receptors
- Receptors, Adrenergic alpha-2B
- alpha-2B Receptors, Adrenergic
- Adrenergic Receptor alpha-2b
- Adrenergic Receptor alpha 2b
- Receptor alpha-2b, Adrenergic
- alpha-2b, Adrenergic Receptor
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Below are MeSH descriptors whose meaning is more general than "Receptors, Adrenergic, alpha-2".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Biogenic Amine [D12.776.543.750.070]
- Receptors, Catecholamine [D12.776.543.750.070.300]
- Receptors, Adrenergic [D12.776.543.750.070.300.300]
- Receptors, Adrenergic, alpha [D12.776.543.750.070.300.300.300]
- Receptors, Adrenergic, alpha-2 [D12.776.543.750.070.300.300.300.725]
- Receptors, G-Protein-Coupled [D12.776.543.750.100]
- Receptors, Catecholamine [D12.776.543.750.100.150]
- Receptors, Adrenergic [D12.776.543.750.100.150.300]
- Receptors, Adrenergic, alpha [D12.776.543.750.100.150.300.300]
- Receptors, Adrenergic, alpha-2 [D12.776.543.750.100.150.300.300.725]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Biogenic Amine [D12.776.543.750.720.300]
- Receptors, Catecholamine [D12.776.543.750.720.300.300]
- Receptors, Adrenergic [D12.776.543.750.720.300.300.300]
- Receptors, Adrenergic, alpha [D12.776.543.750.720.300.300.300.300]
- Receptors, Adrenergic, alpha-2 [D12.776.543.750.720.300.300.300.300.200]
Below are MeSH descriptors whose meaning is more specific than "Receptors, Adrenergic, alpha-2".
This graph shows the total number of publications written about "Receptors, Adrenergic, alpha-2" by people in this website by year, and whether "Receptors, Adrenergic, alpha-2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 | | 1996 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 1998 | 2 | 1 | 3 | | 2006 | 1 | 0 | 1 | | 2009 | 2 | 0 | 2 | | 2011 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptors, Adrenergic, alpha-2" by people in Profiles.
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MacKillop J, Gray JC, Weafer J, Sanchez-Roige S, Palmer AA, de Wit H. Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach. Exp Clin Psychopharmacol. 2019 Feb; 27(1):29-37.
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Kohli U, Diedrich A, Kannankeril PJ, Muszkat M, Sofowora GG, Hahn MK, English BA, Blakely RD, Stein CM, Kurnik D. Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise. Physiol Genomics. 2015 Sep; 47(9):400-6.
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Raj SM, Pagani L, Gallego Romero I, Kivisild T, Amos W. A general linear model-based approach for inferring selection to climate. BMC Genet. 2013 Sep 22; 14:87.
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Viemari JC, Garcia AJ, Doi A, Ramirez JM. Activation of alpha-2 noradrenergic receptors is critical for the generation of fictive eupnea and fictive gasping inspiratory activities in mammals in vitro. Eur J Neurosci. 2011 Jun; 33(12):2228-37.
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Musch MW, Arvans DL, Paris H, Chang EB. Alpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3. J Pharmacol Exp Ther. 2009 Sep; 330(3):818-25.
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Kohli U, Muszkat M, Sofowora GG, Harris PA, Friedman EA, Dupont WD, Scheinin M, Wood AJ, Stein CM, Kurnik D. Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception. Eur J Pain. 2010 Feb; 14(2):154-9.
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Keedy SK, Marlow-O'Connor M, Beenken B, Dorflinger J, Abel M, Erwin RJ. Noradrenergic antagonism of the P13 and N40 components of the rat auditory evoked potential. Psychopharmacology (Berl). 2007 Jan; 190(1):117-25.
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Maitland ML, Gomberg-Maitland M. Polymorphisms of adrenergic receptors and the risk of heart failure. N Engl J Med. 2003 Jan 30; 348(5):468-70; author reply 468-70.
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Ernsberger P, Kou YR, Prabhakar NR. Carotid body I1-imidazoline receptors: binding, visualization and modulatory function. Respir Physiol. 1998 Jun; 112(3):239-51.
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MacMillan LB, Lakhlani P, Lovinger D, Limbird LE. Alpha 2-adrenergic receptor subtypes: subtle mutation of the alpha 2A-adrenergic receptor in vivo by gene targeting strategies reveals the role of this subtype in multiple physiological settings. Recent Prog Horm Res. 1998; 53:25-42.
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