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Alfredo Garcia

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Emergency Medicine
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    My research is focused on understanding how local brain circuit physiology is impacted by changes in blood gas homeostasis. We study the hippocampus, a brain region important to learning and memory, and brainstem networks involved cardio-respiratory control.
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    Collapse Biography 
    Collapse education and training
    The Ohio State University, Columbus, OhioB.Sc.06/1999Biological Science
    Wright State University, Dayton, OhioPh.D.05/2006Biomedical Science
    The University of Chicago, Chicago, IllinoisPostdoctoral Fellowship06/2009Neuroscience

    Collapse Research 
    Collapse research activities and funding
    R01DA061412     (GARCIA, ALFREDO J)Jul 15, 2024 - May 31, 2027
    NIH
    Investigating the mechanistic consequences of fentanyl-induced hypoxia and cardiorespiratory collapse
    Role: Principal Investigator
    R01HL169679     (SHARP, WILLARD WILLIAM)Apr 2, 2024 - Jan 31, 2028
    NIH
    Resuscitating the Brain and Heart Following Cardiac Arrest: Targeting Oxygen Toxicity
    Role: Co-Principal Investigator
    R01HL163965     (GARCIA, ALFREDO J)Aug 5, 2022 - May 31, 2026
    NIH
    Mechanisms of repeated opioid use dependent remodeling in respiratory control
    Role: Principal Investigator
    R01NS107421     (GARCIA, ALFREDO J)May 1, 2018 - Apr 30, 2024
    NIH
    Neurocognitive Consequences of Intermittent Hypoxia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Joana Alves M, Browe BM, Carolina Rodrigues Dias A, Zaza G, Bangudi S, Blackburn J, Wang W, de Araujo Fernandes-Junior S, Toland A, Baer LA, Stanford KI, Czeisler C, Javier Otero J, Torres JM, Fadda P, Garcia AJ. Metabolic trade-offs in Neonatal sepsis triggered by TLR4 and TLR1/2 ligands result in unique dysfunctions in neural breathing circuits. Brain Behav Immun. 2024 Jul; 119:333-350. PMID: 38561095.
      Citations:    Fields:    Translation:AnimalsCells
    2. Piao L, Fang YH, Fisher M, Hamanaka RB, Ousta A, Wu R, Mutlu GM, Garcia AJ, Archer SL, Sharp WW. Dynamin-related protein 1 is a critical regulator of mitochondrial calcium homeostasis during myocardial ischemia/reperfusion injury. FASEB J. 2024 01; 38(1):e23379. PMID: 38133921.
      Citations: 2     Fields:    Translation:AnimalsCells
    3. Arias-Cavieres A, Garcia AJ. A consequence of immature breathing induces persistent changes in hippocampal synaptic plasticity and behavior: a role of prooxidant state and NMDA receptor imbalance. Front Mol Neurosci. 2023; 16:1192833. PMID: 37456523; PMCID: PMC10338931.
      Citations:    
    4. Arias-Cavieres A, Garcia AJ. A Consequence of Immature Breathing induces Persistent Changes in Hippocampal Synaptic Plasticity and Behavior: A Role of Pro-Oxidant State and NMDA Receptor Imbalance. bioRxiv. 2023 Mar 21. PMID: 36993632; PMCID: PMC10055328.
      Citations:    
    5. Browe BM, Peng YJ, Nanduri J, Prabhakar NR, Garcia AJ. Gasotransmitter modulation of hypoglossal motoneuron activity. Elife. 2023 01 19; 12. PMID: 36656752; PMCID: PMC9977277.
      Citations: 1     Fields:    Translation:AnimalsCells
    6. Poli JA, Howard C, Garcia AJ, Remboski D, Littlewood PB, Kress JP, Kasthuri N, Comai A, Soni K, Kennedy P, Ogger J, DiBlasi RM. Performance Characteristics of a Novel 3D-Printed Bubble Intermittent Mandatory Ventilator (B-IMV) for Adult Pulmonary Support. Bioengineering (Basel). 2022 Apr 02; 9(4). PMID: 35447711; PMCID: PMC9027535.
      Citations: 1     
    7. Dalgin G, Tryba AK, Cohen AP, Park SY, Philipson LH, Greeley SAW, Garcia AJ. Developmental defects and impaired network excitability in a cerebral organoid model of KCNJ11 p.V59M-related neonatal diabetes. Sci Rep. 2021 11 03; 11(1):21590. PMID: 34732776; PMCID: PMC8566525.
      Citations: 6     Fields:    Translation:HumansCells
    8. Ousta A, Piao L, Fang YH, Vera A, Nallamothu T, Garcia AJ, Sharp WW. Microglial Activation and Neurological Outcomes in a Murine Model of Cardiac Arrest. Neurocrit Care. 2022 02; 36(1):61-70. PMID: 34268646; PMCID: PMC8813848.
      Citations: 5     Fields:    Translation:AnimalsCells
    9. Arias-Cavieres A, Fonteh A, Castro-Rivera CI, Garcia AJ. Intermittent Hypoxia causes targeted disruption to NMDA receptor dependent synaptic plasticity in area CA1 of the hippocampus. Exp Neurol. 2021 10; 344:113808. PMID: 34256046; PMCID: PMC8962677.
      Citations: 7     Fields:    Translation:AnimalsCells
    10. Wang W, Alzate-Correa D, Alves MJ, Jones M, Garcia AJ, Zhao J, Czeisler CM, Otero JJ. Machine learning-based data analytic approaches for evaluating post-natal mouse respiratory physiological evolution. Respir Physiol Neurobiol. 2021 01; 283:103558. PMID: 33010456; PMCID: PMC7881416.
      Citations: 2     Fields:    Translation:Animals
    11. Alzate-Correa D, Mei-Ling Liu J, Jones M, Alves MJ, Burke E, Kaya B, Zaza G, Aslan MT, Blackburn J, Baer LA, Stanford KI, Kempton A, Smith S, Szujewski CC, Silbaugh A, Viemari JC, Garcia AJ, Czeisler CM, Silva TM, Zuñiga J, Shimada MY, Fernandes-Junior SA, Takakura AC, Moreira TS, Otero JJ. Neonatal apneic phenotype in a murine congenital central hypoventilation syndrome model is induced through non-cell autonomous developmental mechanisms. Brain Pathol. 2021 01; 31(1):84-102. PMID: 32654284; PMCID: PMC7881415.
      Citations: 8     Fields:    Translation:AnimalsCells
    12. Arias-Cavieres A, Khuu MA, Nwakudu CU, Barnard JE, Dalgin G, Garcia AJ. A HIF1a-Dependent Pro-Oxidant State Disrupts Synaptic Plasticity and Impairs Spatial Memory in Response to Intermittent Hypoxia. eNeuro. 2020 May/Jun; 7(3). PMID: 32493757; PMCID: PMC7363479.
      Citations: 27     Fields:    Translation:Animals
    13. Garcia AJ, Szujewski CC. Finding inspiration in opioid-induced respiratory depression. J Physiol. 2020 01; 598(1):3. PMID: 31675443; PMCID: PMC7039442.
      Citations:    Fields:    Translation:Animals
    14. Garcia AJ, Khuu MA, Viemari JC. Respiratory rhythm generation, hypoxia, and oxidative stress-Implications for development. Respir Physiol Neurobiol. 2019 12; 270:103259. PMID: 31369874; PMCID: PMC7020797.
      Citations: 3     Fields:    Translation:HumansAnimals
    15. Khuu MA, Pagan CM, Nallamothu T, Hevner RF, Hodge RD, Ramirez JM, Garcia AJ. Intermittent Hypoxia Disrupts Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus. J Neurosci. 2019 02 13; 39(7):1320-1331. PMID: 30587544; PMCID: PMC6381238.
      Citations: 36     Fields:    Translation:AnimalsCells
    16. Garcia AJ, Dashevskiy T, Khuu MA, Ramirez JM. Chronic Intermittent Hypoxia Differentially Impacts Different States of Inspiratory Activity at the Level of the preBötzinger Complex. Front Physiol. 2017; 8:571. PMID: 28936176; PMCID: PMC5603985.
      Citations: 24     
    17. Harris KD, Dashevskiy T, Mendoza J, Garcia AJ, Ramirez JM, Shea-Brown E. Different roles for inhibition in the rhythm-generating respiratory network. J Neurophysiol. 2017 10 01; 118(4):2070-2088. PMID: 28615332; PMCID: PMC5626906.
      Citations: 21     Fields:    Translation:Animals
    18. Garcia AJ, Ramirez JM. Keeping carbon dioxide in check. Elife. 2017 05 17; 6. PMID: 28513432; PMCID: PMC5435460.
      Citations: 4     Fields:    Translation:Cells
    19. Anderson TM, Garcia AJ, Baertsch NA, Pollak J, Bloom JC, Wei AD, Rai KG, Ramirez JM. A novel excitatory network for the control of breathing. Nature. 2016 08 04; 536(7614):76-80. PMID: 27462817; PMCID: PMC5479418.
      Citations: 102     Fields:    Translation:AnimalsCells
    20. Garcia AJ, Zanella S, Dashevskiy T, Khan SA, Khuu MA, Prabhakar NR, Ramirez JM. Chronic Intermittent Hypoxia Alters Local Respiratory Circuit Function at the Level of the preBötzinger Complex. Front Neurosci. 2016; 10:4. PMID: 26869872; PMCID: PMC4740384.
      Citations: 33     
    21. Caughie C, Elsen FP, Doi A, Garcia AJ, Zanella S, Ramirez JM, Koch H. Prostaglandin E2 differentially modulates the central control of eupnoea, sighs and gasping in mice. J Physiol. 2015 01 01; 593(1):305-19. PMID: 25556802; PMCID: PMC4293069.
      Citations: 15     Fields:    Translation:AnimalsCells
    22. Ramirez JM, Anderson TM, Garcia AJ. The ins and outs of breathing. Elife. 2014 Jun 17; 3:e03375. PMID: 24940002; PMCID: PMC4060004.
      Citations: 1     Fields:    Translation:AnimalsCells
    23. Doi A, Garcia AJ, Elsen F, Kirsch S, Wei AD, Ramirez JM, Zanella S. When norepinephrine becomes a driver of breathing irregularities: how intermittent hypoxia fundamentally alters the modulatory response of the respiratory network. J Neurosci. 2014 Jan 01; 34(1):36-50. PMID: 24381266; PMCID: PMC3866492.
      Citations: 27     Fields:    Translation:AnimalsCells
    24. Garcia AJ, Doi A, Elsen G, Ramirez JM, Viemari JC. ß-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro. Front Neural Circuits. 2013; 7:179. PMID: 24273495; PMCID: PMC3824105.
      Citations: 22     Fields:    Translation:AnimalsCells
    25. Ramirez JM, Garcia AJ, Anderson TM, Koschnitzky JE, Peng YJ, Kumar GK, Prabhakar NR. Central and peripheral factors contributing to obstructive sleep apneas. Respir Physiol Neurobiol. 2013 Nov 01; 189(2):344-53. PMID: 23770311; PMCID: PMC3901437.
      Citations: 52     Fields:    Translation:Humans
    26. Garcia AJ, Koschnitzky JE, Ramirez JM. The physiological determinants of sudden infant death syndrome. Respir Physiol Neurobiol. 2013 Nov 01; 189(2):288-300. PMID: 23735486; PMCID: PMC3812300.
      Citations: 44     Fields:    Translation:Humans
    27. Garcia AJ, Rotem-Kohavi N, Doi A, Ramirez JM. Post-hypoxic recovery of respiratory rhythm generation is gender dependent. PLoS One. 2013; 8(4):e60695. PMID: 23593283; PMCID: PMC3620234.
      Citations: 19     Fields:    Translation:AnimalsCells
    28. Garcia AJ, Koschnitzky JE, Dashevskiy T, Ramirez JM. Cardiorespiratory coupling in health and disease. Auton Neurosci. 2013 Apr; 175(1-2):26-37. PMID: 23497744; PMCID: PMC3683976.
      Citations: 35     Fields:    Translation:HumansAnimals
    29. Hodge RD, Garcia AJ, Elsen GE, Nelson BR, Mussar KE, Reiner SL, Ramirez JM, Hevner RF. Tbr2 expression in Cajal-Retzius cells and intermediate neuronal progenitors is required for morphogenesis of the dentate gyrus. J Neurosci. 2013 Feb 27; 33(9):4165-80. PMID: 23447624; PMCID: PMC3623668.
      Citations: 45     Fields:    Translation:AnimalsCells
    30. Koch H, Zanella S, Elsen GE, Smith L, Doi A, Garcia AJ, Wei AD, Xun R, Kirsch S, Gomez CM, Hevner RF, Ramirez JM. Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels. J Neurosci. 2013 Feb 20; 33(8):3633-45. PMID: 23426690; PMCID: PMC3652398.
      Citations: 19     Fields:    Translation:Animals
    31. Madisen L, Mao T, Koch H, Zhuo JM, Berenyi A, Fujisawa S, Hsu YW, Garcia AJ, Gu X, Zanella S, Kidney J, Gu H, Mao Y, Hooks BM, Boyden ES, Ramirez JM, Jones AR, Svoboda K, Han X, Turner EE, Zeng H, Buzsáki G. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat Neurosci. 2012 Mar 25; 15(5):793-802. PMID: 22446880; PMCID: PMC3337962.
      Citations: 715     Fields:    Translation:AnimalsCells
    32. Koch H, Garcia AJ, Ramirez JM. Network reconfiguration and neuronal plasticity in rhythm-generating networks. Integr Comp Biol. 2011 Dec; 51(6):856-68. PMID: 21856733; PMCID: PMC3223481.
      Citations: 23     Fields:    Translation:AnimalsCells
    33. Garcia AJ, Khan SA, Kumar GK, Prabhakar NR, Ramirez JM. Hydrogen peroxide differentially affects activity in the pre-Bötzinger complex and hippocampus. J Neurophysiol. 2011 Dec; 106(6):3045-55. PMID: 21849609; PMCID: PMC3234088.
      Citations: 12     Fields:    Translation:AnimalsCells
    34. Garcia AJ, Doi A, Ramirez JM, Viemari JC. Activation of alpha-2 noradrenergic receptors is critical for the generation of fictive eupnea and fictive gasping inspiratory activities in mammals in vitro. Eur J Neurosci. 2011 Jun; 33(12):2228-37. PMID: 21615559; PMCID: PMC3652413.
      Citations: 26     Translation:Animals
    35. Ramirez JM, Koch H, Garcia AJ, Doi A, Zanella S. The role of spiking and bursting pacemakers in the neuronal control of breathing. J Biol Phys. 2011 Jun; 37(3):241-61. PMID: 22654176; PMCID: PMC3101325.
      Citations: 34     Fields:    
    36. Garcia AJ, Zanella S, Koch H, Doi A, Ramirez JM. Chapter 3--networks within networks: the neuronal control of breathing. Prog Brain Res. 2011; 188:31-50. PMID: 21333801; PMCID: PMC3652403.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    37. Hill AA, Garcia AJ, Zanella S, Upadhyaya R, Ramirez JM. Graded reductions in oxygenation evoke graded reconfiguration of the isolated respiratory network. J Neurophysiol. 2011 Feb; 105(2):625-39. PMID: 21084689; PMCID: PMC3059168.
      Citations: 30     Fields:    Translation:Animals
    38. Putnam RW, Dean JB, Garcia AJ. Hyperbaric hyperoxia and normobaric reoxygenation increase excitability and activate oxygen-induced potentiation in CA1 hippocampal neurons. J Appl Physiol (1985). 2010 Sep; 109(3):804-19. PMID: 20558753; PMCID: PMC2944633.
      Citations: 20     Fields:    Translation:AnimalsCells
    39. Garcia AJ, Putnam RW, Dean JB. Hyperoxic stimulation of synchronous orthodromic activity and induction of neural plasticity does not require changes in excitatory synaptic transmission. J Appl Physiol (1985). 2010 Sep; 109(3):820-9. PMID: 20558752; PMCID: PMC2944636.
      Citations: 4     Fields:    Translation:AnimalsCells
    40. Ramirez JM, Garcia A. Point: Medullary pacemaker neurons are essential for both eupnea and gasping in mammals. J Appl Physiol (1985). 2007 Aug; 103(2):717-8; discussion 722. PMID: 17272416.
      Citations: 16     Fields:    Translation:AnimalsCells
    41. Dean JB, Mulkey DK, Garcia AJ, Putnam RW, Henderson RA. Neuronal sensitivity to hyperoxia, hypercapnia, and inert gases at hyperbaric pressures. J Appl Physiol (1985). 2003 Sep; 95(3):883-909. PMID: 12909594.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
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